Mohammad Ali
A5090900874- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Head and Neck Anomalies
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- Hepatitis C virus research
- Synthesis of heterocyclic compounds
- COVID-19 Impact on Reproduction
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Child Nutrition and Water Access
- Head and Neck Cancer Studies
- Hepatitis B Virus Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Ear Surgery and Otitis Media
- Head and Neck Surgical Oncology
- Breastfeeding Practices and Influences
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis and biological activity
- Congenital Ear and Nasal Anomalies
- Nasal Surgery and Airway Studies
- HIV-related health complications and treatments
University of Oxford
2020-2025
Medawar Building for Pathogen Research
2020-2025
Nuffield Health
2024
Mahidol Oxford Tropical Medicine Research Unit
2023-2024
Mahidol University
2023-2024
Bangabandhu Sheikh Mujib Medical University
2009-2024
Directorate General of Health Services
2022-2024
Mawlana Bhashani Science and Technology University
2022
University of Maryland, College Park
2022
King Abdulaziz Hospital
2021
Extension of the interval between vaccine doses for BNT162b2 mRNA was introduced in United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed study healthcare workers. The first dose induced protection from infection circulating alpha (B.1.1.7) variant over several weeks. In substudy 589 individuals, show that induces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (NAb) responses sustained...
The extent to which immune responses natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization vaccines protect against variants of concern (VOC) is increasing importance. Accordingly, here we analyse antibodies T cells a recently vaccinated, UK cohort, alongside those recovering from in early 2020. We show that neutralization the VOC compared reference isolate original circulating lineage, B, reduced: more profoundly B.1.351 than for B.1.1.7, or...
Abstract Identification of protective T cell responses against SARS-CoV-2 requires distinguishing people infected with from those cross-reactive immunity to other coronaviruses. Here we show a range assays that differentially capture immune function characterise responses. Strong ex vivo ELISpot and proliferation multiple antigens (including M, NP ORF3) are found in 168 PCR-confirmed volunteers, but rare 119 uninfected volunteers. Highly exposed seronegative healthcare workers recent...
B-cell chronic lymphocytic leukaemia (CLL) is associated with immunosuppression and patients are at increased clinical risk following SARS-CoV-2 infection. Covid-19 vaccines offer the potential for protection against severe infection but relatively little known regarding profile of antibody response first or second vaccination. We studied spike-specific responses and/or vaccination in 299 CLL compared healthy donors. 286 underwent extended interval (10-12 week) 154 received BNT162b2 mRNA...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVID-19) vaccines. Overall, 255 2,204 (12%) failed to develop anti-spike antibodies, an additional 600 (27%) generating low levels (<380 AU ml −1 ). Vaccine failure rates highest ANCA-associated vasculitis on rituximab (21/29, 72%), hemodialysis...
Background: Following a single dose of BNT162b2 mRNA vaccine, higher antibody titres are observed following prior SARS-CoV-2 infection than in infection-naive individuals, but T-cell responses less well defined.Methods: We sampled healthcare workers (HCWs) enrolled the UK PITCH study, before and after vaccination. measured spike-specific antibody, quantified by IFNγ ELISpot assay intracellular staining peripheral blood mononuclear cells (PBMC), comparing SARS-CoV-2-naïve individuals to those...
Bangladesh is a South Asian developing country trying to achieve the Sustainable Development Goals (SDG)-3 and objective of Rural Electrification Board (REB) regarding child mortality. Infectious diseases are leading causes mortality, lack exclusive breastfeeding (EBF) among infants aged 0-6 months increases morbidity mortality from various infectious in countries. However, as per existing literature, no study has been conducted yet determine EBF practice effect on Bangladesh. With this...
Abstract The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study UK healthcare workers prior vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show highly variable range responses, some which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B memory ELISpot) stable. use...
Abstract Background People with human immunodeficiency virus (HIV) on antiretroviral therapy (ART) good CD4 T-cell counts make effective immune responses following vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are few data longer term and the impact of a booster dose. Methods Adults HIV were enrolled into single arm open label study. Two doses ChAdOx1 nCoV-19 followed 12 months later by third heterologous vaccine Participants had undetectable...
<title>Abstract</title> Older adults are particularly vulnerable to infectious diseases, and vaccines often less effective in this population due immunosenescence, which is characterized by diminished B T memory responses. Autophagy believed underlie many facets of cellular aging, including immunosenescence. It crucial for maintaining cell functions but declines with age, along the endogenous metabolite spermidine that helps maintain autophagy levels. We conducted a double-blind, randomized,...
<title>Abstract</title> COVID-19 vaccines were updated to address immune escape from variants of concern (VOC). We explored the impact ancestral/BA.1 bivalent mRNA booster vaccination (Autumn 2022) on peripheral and nasal antibody T-cell responses SARS-CoV-2 in 133 healthcare workers, building previous longitudinal studies. demonstrate that maintenance up eighteen months following third vaccine is at least partially driven by intercurrent infection. Boosting with increases breadth...
The rapid proliferation of germinal center (GC) B cells requires metabolic reprogramming to meet energy demands, yet these processes are poorly understood. By integrating metabolomic and transcriptomic profiling GC cells, we identified that asparagine (Asn) metabolism was highly up-regulated essential for cell function. Asparagine synthetase (ASNS) after activation through the integrated stress response sensor GCN2. Conditional deletion
Defining correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine breakthrough infection informs policy for booster doses and future designs. Existing studies demonstrate humoral protection, but the role T cells in is still unclear. In this study, we explore antibody cell immune responses associated with Delta variant a well-characterized cohort UK Healthcare Workers (HCWs). We evidence to support CD4+ CD8+ as well antibodies infection. addition,...
Framing analysis is predominantly qualitative and quantitative, examining a small dataset with manual coding. Easy access to digital data in the last two decades prompts scholars both computation social sciences utilize various computational methods explore frames large-scale datasets. The growing scholarship, however, lacks comprehensive understanding resources of framing methods. Aiming address gap, this article surveys existing approaches puts them together. research expected help...
Abstract Objective: Obesity and type 2 diabetes (DM) are risk factors for severe coronavirus disease 2019 (COVID-19) outcomes, which disproportionately affect South Asian populations. This study aims to investigate the humoral cellular immune responses SARS-CoV-2 in adult COVID-19 survivors with overweight/obesity (Ov/Ob, BMI ≥ 23 kg/m2) DM Bangladesh. Methods: In this cross-sectional study, SARS-CoV-2-specific antibody T-cell were investigated 63 healthy 75 PCR-confirmed recovered...
Abstract A major issue in identification of protective T cell responses against SARS-CoV-2 lies distinguishing people infected with from those cross-reactive immunity generated by exposure to other coronaviruses. We characterised immune 168 PCR-confirmed subjects and 118 seronegative without known using a range assays that differentially capture function. Strong ex vivo ELISpot proliferation multiple antigens (including M, NP ORF3) were found who had been but rare pre-pandemic unexposed...
Objective: To find out relative frequency and type of malignancy in solitary thyroid nodule (STN).Methods: This cross sectional study done the Department Otolaryngology Head & Neck Surgery, Dhaka Medical College Hospital (DMCH), Bangabandhu Sheikh Mujib University (BSMMU), during period July 2008 to June 2009. For this study, 118 patients who were admitted a case for operation. Diagnosed by detailed history, clinical examination, investigations, analyzed data presented various tables,...
ABSTRACT T cell correlates of protection against SARS-CoV-2 infection after vaccination (‘vaccine breakthrough’) are incompletely defined, especially the specific contributions CD4+ and CD8+ cells. We studied 279 volunteers in Protective Immunity from Cells Healthcare Workers (PITCH) UK study, including 32 cases (with positive testing two vaccine doses during Delta-dominant era) 247 controls (no test nor anti-nucleocapsid seroconversion this period). 28 days second vaccination, before all...