A5051369698- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Face Recognition and Perception
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Visual Attention and Saliency Detection
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Motor Control and Adaptation
- Retinal Development and Disorders
- EEG and Brain-Computer Interfaces
- Spatial Cognition and Navigation
- Advanced Neuroimaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Image Retrieval and Classification Techniques
- Atomic and Subatomic Physics Research
- Advanced Image and Video Retrieval Techniques
- Muscle activation and electromyography studies
- Categorization, perception, and language
- Psychological and Temporal Perspectives Research
- Sport Psychology and Performance
- Advanced Vision and Imaging
- Cognitive Science and Education Research
University of Illinois System
2025
University of Oxford
1979-2025
University of Illinois Urbana-Champaign
2024-2025
Dartmouth College
2020-2024
Dartmouth Hospital
2020-2024
Brain (Germany)
2022
European Organization for Nuclear Research
2021
Wellcome Centre for Integrative Neuroimaging
2016-2020
Wellcome Trust
2018-2020
National Institutes of Health
2015-2019
Human medial parietal cortex (MPC) is implicated in multiple cognitive processes including memory recall, visual scene processing and navigation, a core component of the default mode network. Here, we demonstrate distinct subdivisions MPC that are selectively recruited during recall either specific people or places. First, regions exhibited differential functional connectivity with lateral ventral temporal (VTC). Second, these same showed selective, but negative, responses to presentation...
Functional imaging studies in human reliably identify a trio of scene-selective regions, one on each the lateral (occipital place area, OPA), ventral (parahippocampal PPA), and medial (retrosplenial complex, RSC) cortical surfaces. Recently, we demonstrated differential retinotopic biases for contralateral lower upper visual fields within OPA PPA, respectively. Here, using fMRI, combine detailed mapping both population receptive (pRF) category-selectivity, with independently acquired...
The neural systems supporting scene-perception and spatial-memory of the human brain are well-described. But how do these interact? Here, using fine-grained individual-subject fMRI, we report three cortical areas brain, each lying immediately anterior to a region scene perception network in posterior cerebral cortex, that selectively activate when recalling familiar real-world locations. Despite their close proximity areas, analyses show regions constitute distinct functional interfaces with...
To fluidly engage with the world, our brains must simultaneously represent both scene in front of us and memory immediate surrounding environment (i.e., local visuospatial context). How does brain's functional architecture enable sensory mnemonic representations to closely interface while also avoiding sensory-mnemonic interference? Here, we asked this question using first-person, head-mounted virtual reality fMRI. Using reality, human participants sexes learned a set immersive, real-world...
Adaptive behavior in complex environments requires integrating visual perception with memory of our spatial environment. Recent work has implicated three brain areas posterior cerebral cortex - the place (PMAs) that are anterior to scene (SPAs) this function. However, PMAs' relationship broader cortical hierarchy remains unclear due limited group-level characterization. Here, we examined PMA and SPA locations across fMRI datasets (44 participants, 29 female). SPAs were identified using a...
Adaptive behavior in complex environments requires integrating visual perception with memory of our spatial environment. Recent work has implicated three brain areas posterior cerebral cortex — the place (PMAs) that are anterior to scene (SPAs) – this function. However, PMAs’ relationship broader cortical hierarchy remains unclear due limited group-level characterization. Here, we examined PMA and SPA locations across fMRI datasets (44 participants, 29 female). SPAs were identified using a...
Individuals with developmental prosopagnosia (DP) experience face recognition impairments despite normal intellect and low-level vision no history of brain damage. Prior studies using diffusion tensor imaging in small samples subjects DP (n=6 or n=8) offer conflicting views on the neurobiological bases for DP, one suggesting white matter differences two major long-range tracts running through temporal cortex, another confined to fibers local ventral face-specific functional regions interest...
Abstract Reward and punishment motivate behavior, but it is unclear exactly how they impact skill performance whether the effect varies across skills. The present study investigated of reward in both a sequencing motor context. Participants trained on either (serial reaction time task) or (force-tracking task). Skill knowledge was tested immediately after training, again 1 hour, 24–48 hours, 30 days training. We found dissociation effects tasks, primarily reflecting punishment. While...
Human retrosplenial complex (RSC), located in medial parietal cortex, has been implicated numerous cognitive functions, including scene perception, spatial navigation, and autobiographical memory retrieval. Recently, a posterior-anterior distinction within RSC was proposed, such that posterior aspects process scene-related visual information (constituting place area [MPA]), whereas anterior is vividly retrieved from memory, thereby supporting remembering potentially navigation. Here, we...
Models of healthy brain function and psychiatric conditions assume that excitatory inhibitory activity are balanced in the human at multiple spatial temporal scales. In neuroimaging, concentrations major (glutamate) (γ-aminobutyric acid, GABA) neurotransmitters measured vivo using magnetic resonance spectroscopy (MRS). However, despite central importance E/I balance to theories function, a relationship between regional glutamate GABA levels has not been shown. We addressed this question...
It has been shown that density‐weighted (DW) k ‐space sampling with spiral and conventional phase encoding trajectories reduces spatial side lobes in magnetic resonance spectroscopic imaging (MRSI). In this study, we propose a new concentric ring trajectory (CRT) for DW‐MRSI samples density is proportional to spatial, isotropic Hanning window. The properties of two different DW‐CRTs were compared against radially equidistant (RE) CRT an echo‐planar (EPSI) simulations, phantoms vivo...
Abstract Magnetic resonance spectroscopic imaging (MRSI) is a promising technique in both experimental and clinical settings. However, to date, MRSI has been hampered by prohibitively long acquisition times artifacts caused subject motion hardware-related frequency drift. In the present study, we demonstrate that density weighted concentric ring trajectory (DW-CRT) k-space sampling combination with semi-LASER excitation metabolite-cycling enables high-resolution data be rapidly acquired at 3...
<title>Abstract</title> COVID-19 vaccines were updated to address immune escape from variants of concern (VOC). We explored the impact ancestral/BA.1 bivalent mRNA booster vaccination (Autumn 2022) on peripheral and nasal antibody T-cell responses SARS-CoV-2 in 133 healthcare workers, building previous longitudinal studies. demonstrate that maintenance up eighteen months following third vaccine is at least partially driven by intercurrent infection. Boosting with increases breadth...
A bstract Here, we report a network of brain areas bridging the spatial-memory and scene-perception systems human brain. Using fine-grained individual-subject fMRI, reveal three cortical brain, each lying immediately anterior to region scene perception in posterior cerebral cortex, that selectively activate when recalling familiar real-world locations. Despite their close proximity areas, analyses show these regions constitute distinct functional interfaces with memory during naturalistic...
The posterior cingulate cortex (PCC) and corpus callosum (CC) are susceptible to trauma, but injury often evades detection. PCC Metabolic disruption may predict CC white matter tract the secondary cascade responsible for progression. While time frame remains unclear in humans, first 24 h (hyper-acute phase) crucial life-saving interventions. Objectives: To test whether Magnetic Resonance Imaging (MRI) markers detectable hyper-acute phase progress after traumatic brain (TBI) alterations these...