A5053248537- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Advanced biosensing and bioanalysis techniques
- Rheumatoid Arthritis Research and Therapies
- Bioinformatics and Genomic Networks
- Traditional Chinese Medicine Analysis
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Microbial infections and disease research
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Inflammasome and immune disorders
- Cardiac Ischemia and Reperfusion
- Biosensors and Analytical Detection
- Biochemical and Molecular Research
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Environmental Impact and Sustainability
- Viral gastroenteritis research and epidemiology
University of Oxford
2015-2024
Nuffield Orthopaedic Centre
2015-2024
Hunan Agricultural University
2023-2024
Nanjing Agricultural University
2023
Changzhou No.2 People's Hospital
2022
Nanjing Medical University
2022
South China Agricultural University
2020-2022
South China University of Technology
2022
Fujian Agriculture and Forestry University
2017-2022
Sir Run Run Shaw Hospital
2022
Endoplasmatic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in trimming of peptides to an optimal length for presentation by major histocompatibility complex (MHC) class I molecules. Polymorphisms ERAP1 have been associated with chronic inflammatory diseases, including ankylosing spondylitis (AS) and psoriasis, subsequent vitro studies suggest distinct catalytic properties variants. To understand structure-activity relationships this we determined crystal structures...
Multiple cytokines, including interleukin 6 (IL-6), IL-11, IL-27, oncostatin M (OSM), and leukemia inhibitory factor (LIF), signal via the common GP130 cytokine receptor subunit. In this study, we describe a patient with homozygous mutation of IL6ST (encoding p.N404Y) who presented recurrent infections, eczema, bronchiectasis, high IgE, eosinophilia, defective B cell memory, an impaired acute-phase response, as well skeletal abnormalities craniosynostosis. The p.N404Y missense substitution...
<h3>Objective</h3> Human leucocyte antigen (HLA)-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly associated with ankylosing spondylitis (AS). ERAP1 is a key in HLA class I presentation can potentially alter surface expression of HLA-B27 free heavy chains (FHCs). We studied the effects silencing/inhibition/variations on FHC Th17 responses AS. <h3>Methods</h3> Flow cytometry was used to measure peripheral blood mononuclear cells (PBMCs) from patients AS carrying different...
HLA-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are the two strongest genetic factors predisposing to ankylosing spondylitis (AS). A key in class I major histocompatibility complex presentation, ERAP1 potentially contributes pathogenesis of AS by altering peptide presentation. The aim this study was analyze effects on repertoire presentation cytotoxic T lymphocytes (CTLs).
To explore the functional basis for association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in IL23R-IL12RB2 intergenic region. We performed conditional analysis on genetic data used epigenetic chromatin remodelling transcription factor (TF) binding to identify primary AS-associated SNP. Functional effects were tested luciferase reporter assays HEK293T cells allele-specific TF was investigated by electrophoretic mobility gel shift assays. IL23R IL12RB2 mRNA...
Cross-disease genome-wide association studies (GWASs) unveil pleiotropic loci, mostly situated within the non-coding genome, each of which exerts effects across multiple diseases. However, challenge "W-H-W" (namely, whether, how, and in specific diseases pleiotropy can inform clinical therapeutics) calls for effective integrative approaches tools. We here introduce a pleiotropy-driven approach specifically designed therapeutic target prioritization evaluation from cross-disease GWAS summary...
Interleukin-1 beta (IL-1β) is known as an inflammasome-dependent pro-inflammatory cytokine that has been implicated in T-cell-driven autoimmune diseases. In mice, T-cells were reported to instruct myeloid cells produce IL-1β via inflammasome-independent mechanism, engages TNFR and Fas-caspase-8-dependent signalling pathways. this study, we explored production humans. Co-culturing of autologous primary (memory CD4+ CD8+) with (monocyte, macrophage dendritic cells) revealed both memory CD8+ T...
<title>Abstract</title> Older adults are particularly vulnerable to infectious diseases, and vaccines often less effective in this population due immunosenescence, which is characterized by diminished B T memory responses. Autophagy believed underlie many facets of cellular aging, including immunosenescence. It crucial for maintaining cell functions but declines with age, along the endogenous metabolite spermidine that helps maintain autophagy levels. We conducted a double-blind, randomized,...
Treatment options for Ankylosing Spondylitis (AS) are still limited. The T helper cell 17 (Th17) pathway has emerged as a major driver of disease pathogenesis and good treatment target. Janus kinases (JAK) key transducers cytokine signals in Th17 cells therefore promising targets the AS. Here we investigate therapeutic potential four different JAK inhibitors on derived from AS patients healthy controls, cultured in-vitro under Th17-promoting conditions. Levels IL-17A, IL-17F, IL-22, GM-CSF...
The immune system is highly diverse, but characterization of its genetic architecture has lagged behind the vast progress made by genome-wide association studies (GWASs) emergent diseases. Our GWAS for 54 functionally relevant phenotypes adaptive in 489 healthy individuals identifies eight significant associations explaining 6%–20% variance. Coding and splicing variants PTPRC COMMD10 are involved memory T cell differentiation. Genetic variation controlling disease-relevant helper subsets...
Abstract The hamster has been shown to share a variety of metabolic similarities with humans. To replicate human acute pancreatitis hamsters, we comparatively studied the efficacy common methods, such as peritoneal injections caerulein, L-arginine, retrograde infusion sodium taurocholate, and another novel model concomitant administration ethanol fatty acid. severity was evaluated by serum amylase activity, pathological scores, myeloperoxidase expression inflammation factors in pancreas....
Objectives: GM-CSF is a pro-inflammatory cytokine with multiple actions predominantly on myeloid cells. Enhanced expression by lymphocytes from patients Ankylosing Spondylitis (AS) has recently been described, however, its potential pathogenic role(s) in AS are unknown. Methods: The effects of TNF, IL-23 and CCL17 production blood, PBMCs isolated CD14+ monocytes healthy controls (HCs) were studied using ELISA. Serum T cell including pre-and TNFi therapy. Results: markedly increased TNF...
Forest carbon sink efficiency refers to the of input-output indicators related sinks. This paper studies from perspective resource allocation; guides optimal allocation resources; and selects forestry employees, investment amount afforestation area as input indicators; forest in China is calculated analyzed based on a data envelopment analysis model by converting volume into through expansion factor method. The grey prediction used estimate change indicator, production possibility set...
Influenza PAN inhibitors are of particular importance in current efforts to develop a new generation antiviral drugs due the growing emergence highly pathogenic influenza viruses and resistance existing inhibitors. Herein, we design synthesize set 1,3-cis-N-substituted-1,2,3,4-tetrahydroisoquinoline derivatives enhance their potency by further exploiting pockets 3 4 endonuclease based on hit d,l-laudanosoline. Particularly, lead compound 35 exhibited potent broad anti-influenza virus effects...