Marijne Vandebergh
A5033314142- Multiple Sclerosis Research Studies
- Amyotrophic Lateral Sclerosis Research
- Systemic Lupus Erythematosus Research
- Genetic Associations and Epidemiology
- Gene expression and cancer classification
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- T-cell and Retrovirus Studies
- Dementia and Cognitive Impairment Research
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Cytokine Signaling Pathways and Interactions
- Spondyloarthritis Studies and Treatments
- Cancer-related molecular mechanisms research
- Powdery Mildew Fungal Diseases
- Glioma Diagnosis and Treatment
- Celiac Disease Research and Management
- RNA regulation and disease
- Neurogenetic and Muscular Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Palliative Care and End-of-Life Issues
- Diabetes and associated disorders
- Parasites and Host Interactions
- Parkinson's Disease Mechanisms and Treatments
VIB-UAntwerp Center for Molecular Neurology
2024-2025
University of Antwerp
2024-2025
University of California, Los Angeles
2024
KU Leuven
2018-2024
Universitat de Barcelona
2024
Hospital Clínic de Barcelona
2024
Fundació Clínic per a la Recerca Biomèdica
2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2024
VIB-KU Leuven Center for Brain & Disease Research
2018-2023
Decreased vitamin D levels and obesity are associated with an increased risk for multiple sclerosis (MS). However, whether they also affect the disease course after onset remains unclear. With larger data sets now available, we used Mendelian randomization (MR) to determine serum 25-hydroxyvitamin (25OHD) body mass index (BMI) causally MS and, moving beyond susceptibility toward heterogeneity, relapse hazard.We genetic variants from 4 distinct genome-wide association studies (GWASs) 25OHD in...
Juvenile idiopathic arthritis (JIA) is the most common class of childhood rheumatic diseases, with distinct disease subsets that may have diverging pathophysiological origins. Both adaptive and innate immune processes been proposed as primary drivers, which account for observed clinical heterogeneity, but few high-depth studies performed.Here we profiled system 85 patients JIA 43 age-matched controls indepth flow cytometry machine learning approaches.Immune profiling identified immunological...
Objectives We explored whether genetically predicted increased body mass index (BMI) modulates multiple sclerosis (MS) risk through interleukin-6 (IL-6) signaling. Methods performed a two-sample Mendelian randomization (MR) study using genome-wide association studies (GWAS) datasets for BMI, IL-6 signaling, levels and c-reactive protein (CRP) as exposures estimated their effects on of MS from GWAS data the International Multiple Sclerosis Genetics Consortium (IMSGC) in 14,802 cases 26,703...
The immune system is highly diverse, but characterization of its genetic architecture has lagged behind the vast progress made by genome-wide association studies (GWASs) emergent diseases. Our GWAS for 54 functionally relevant phenotypes adaptive in 489 healthy individuals identifies eight significant associations explaining 6%–20% variance. Coding and splicing variants PTPRC COMMD10 are involved memory T cell differentiation. Genetic variation controlling disease-relevant helper subsets...
Objective Evidence for a role of microglia in the pathogenesis multiple sclerosis (MS) is growing. We investigated association microglial markers at time diagnostic lumbar puncture (LP) with different aspects disease activity (relapses, disability, magnetic resonance imaging parameters) up to 6 years later cohort 143 patients. Methods In cerebrospinal fluid (CSF), we measured 3 macrophage and microglia‐related proteins, chitotriosidase (CHIT1), chitinase‐3–like protein 1 (CHI3L1 or YKL‐40),...
has been proposed as a modifier of disease risk in FTLD-TDP, particularly
Many multiple sclerosis (MS) genetic susceptibility variants have been identified, but understanding disease heterogeneity remains a key challenge. Relapses are core feature of MS and common primary outcome clinical trials, with prevention relapses benefiting patients immediately potentially limiting long-term disability accrual. We aim to identify variation associated relapse hazard in by analyzing the largest study population date.We performed genomewide association (GWAS) discovery cohort...
Abstract Background Striking changes in the demographic pattern of multiple sclerosis (MS) strongly indicate an influence modifiable exposures, which lend themselves well to intervention. It is important pinpoint many environmental, lifestyle, and sociodemographic that have occurred over past decades, such as higher smoking obesity rates, are responsible. Mendelian randomization (MR) elegant tool overcome limitations inherent observational studies leverage human genetics inform prevention...
Abstract The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. We leveraged aptamer-based proteomics (> 4,000 proteins) to identify dysregulated communities co-expressed cerebrospinal fluid proteins in 116 adults carrying autosomal dominant FTLD mutations ( C9orf72 , GRN MAPT ) compared 39 noncarrier controls. Network analysis identified 31 protein co-expression modules. Proteomic...
Abstract The immune system plays a crucial role in many human diseases. In this context, genome-wide association studies (GWAS) offer valuable insights to elucidate the of immunity health and disease. present multi-omics study aimed identify genetic determinants cell type distributions blood healthy individuals assess whether these cells may play for autoimmune COVID-19 disease risk. To end, frequencies different 483 from Berlin Aging Study II were quantified using flow cytometry, GWAS was...
Background: In contrast to successes for multiple sclerosis (MS) susceptibility, the genetic basis clinical heterogeneity remains largely unresolved. Objectives: We investigate first reported association with relapse rate. Methods: genotyped variant rs12988804 in LRP2 a homogeneous study population of 527 Belgian MS patients 970 documented relapses. Results: The rs12988804*T allele is associated 1.16-fold increased hazard rate occurring ( P = 0.0078) and higher baseline prior...
Pathogenic variants in the
Magnetization transfer ratio (MTR) and brain volumetric imaging are (semi-)quantitative MRI markers capturing demyelination, axonal degeneration and/or inflammation. However, factors shaping variation in these traits largely unknown. In this study, we collected a longitudinal cohort of 33 multiple sclerosis (MS) patients extended it cross-sectionally to 213. We measured MTR lesions, normal-appearing white matter (NAWM), grey (NAGM) total brain, matter, lesion volume. also calculated the...
ABSTRACT Background and Objectives TMEM106B has been proposed as a modifier of disease risk in FTLD-TDP, particularly GRN mutation carriers. Furthermore, investigated the context healthy aging across multiple neurodegenerative diseases. The objective this study is to evaluate compare effect on gray matter volume cognition each common genetic FTD groups sporadic patients. Methods Participants were enrolled through ARTFL/LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) study,...