A5065946542- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neurological Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Ethics in Clinical Research
- Cholinesterase and Neurodegenerative Diseases
- Brain Tumor Detection and Classification
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cognitive Functions and Memory
- Diet and metabolism studies
- Technology Use by Older Adults
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neurological diseases and metabolism
- Cerebrovascular and Carotid Artery Diseases
- Memory and Neural Mechanisms
- Cognitive Abilities and Testing
- Neurological disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
University of North Carolina at Chapel Hill
2021-2025
VIB-UAntwerp Center for Molecular Neurology
2024
University of Antwerp
2024
University of California, Los Angeles
2024
Thomas Jefferson University
2024
University of Miami
2024
University of California, San Diego
2008-2024
University of Pennsylvania
2024
Children's Healthcare of Atlanta
2024
Michigan State University
2012-2021
In vivo imaging of brain β-amyloid, a hallmark Alzheimer disease, may assist in the clinical assessment suspected disease. To determine sensitivity and specificity positron emission tomography with flutemetamol injection labeled radioactive fluorine 18 to detect β-amyloid using neuropathologically determined neuritic plaque levels as standard truth. Open-label multicenter study that took place at dementia clinics, memory centers, hospice centers United States England from June 22, 2010,...
Background Individuals with mild cognitive impairment (MCI) have a substantially increased risk of developing dementia due to Alzheimer's disease (AD). In this study, we developed multivariate prognostic model for predicting MCI-to-dementia progression at the individual patient level. Methods Using baseline data from 259 MCI patients and probabilistic, kernel-based pattern classification approach, trained classifier distinguish between who progressed AD-type (n = 139) those did not 120)...
Background: Some elderly individuals exhibit significant memory deficits but do not have dementia because their general intellect is preserved and they no impairments in everyday activities.These symptoms are often a precursor to Alzheimer disease (AD), sometimes does occur, even after many years of observation.There currently reliable way distinguish between these 2 possible outcomes an individual patient.We hypothesized that clear at least 1 cognitive domain addition would help identify...
Background: Certain patterns can induce perceptual illusions/distortions and visual discomfort in most people, headaches patients with migraine, seizures photosensitive epilepsy. Visual stimuli are common triggers for migraine attacks, possibly because of a hyperexcitability the cortex shown migraine. Precision ophthalmic tints (POTs) claimed to reduce distortions prevent some patients. We report an fMRI cortical activation study designed investigate neurological mechanisms beneficial...
This study examined whether distinct neuropsychological profiles could be delineated in a sample with Mild Cognitive Impairment (MCI) and white matter lesion (WML) burden contributed to MCI group differences. A heterogeneous, clinical of 70 older adults diagnosed was assessed using cognitive scores, WML quantified semi-automated, volumetric approach on T2-weighted fluid-attenuated inversion recovery (FLAIR) images. Using cluster discriminant analyses, three groups (Memory/Language,...
Frontotemporal dementia (FTD) therapy development is hamstrung by a lack of susceptibility, diagnostic, and prognostic biomarkers. Blood neurofilament light (NfL) shows promise as biomarker, but studies have largely focused only on core FTD syndromes, often grouping patients with different diagnoses. To expedite the clinical translation NfL, we avail ARTFL LEFFTDS Longitudinal Lobar Degeneration (ALLFTD) study resources conduct comprehensive investigation plasma NfL across syndromes in...
Importance Frontotemporal lobar degeneration (FTLD) is relatively rare, behavioral and motor symptoms increase travel burden, standard neuropsychological tests are not sensitive to early-stage disease. Remote smartphone-based cognitive assessments could mitigate these barriers trial recruitment success, but no such tools validated for FTLD. Objective To evaluate the reliability validity of measures remote FTLD evaluations. Design, Setting, Participants In this cohort study conducted from...
Background: Clinical trials of anti-Aβ monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal (CSF) Aβ42/40.However, these measure deposits indirectly incompletely.In contrast, postmortem neuropathologic assessments allow direct investigation treatment effects on brain and many other pathologic features.Methods: From a clinical trial dominantly inherited AD, we measured...
Associations between regional white matter lesion pathology and neuropsychological performance across the aging spectrum are not well understood and, to date, research has been largely contradictory inconclusive. The current study set out clarify some of inconsistencies in literature by relating volumetric analyses lesions (deep periventricular lesions) a large clinical sample older adults diagnosed with mild cognitive impairment.Seventy impairment were administered comprehensive battery....
We applied a multi-modal imaging approach to examine structural and functional alterations in the default-mode network (DMN) that are associated with Alzheimer's disease (AD) amnestic mild cognitive impairment (aMCI), transitional phase between
Abstract Background: Alzheimer's disease (AD) and mild cognitive impairment (MCI) affect the limbic system, causing medial temporal lobe (MTL) atrophy posterior cingulate cortex (PCC) hypometabolism. Additionally, diffusion tensor imaging (DTI) studies have demonstrated that MCI AD involve alterations in cerebral white matter (WM) integrity. Objectives: To test if (1) patients with exhibit decreases integrity of WM pathways; (2) disconnection between PCC MTL, manifested as disruption...
Abstract Introduction Performance of the amyloid tracer [ 18 F]flutemetamol was evaluated against three pathology standard truth (SoT) measures including neuritic plaques (CERAD “original” and “modified” component 2012 NIA‐AA guidelines). Methods After imaging, 106 end‐of‐life patients who died underwent postmortem brain examination for plaque load. Blinded positron emission tomography scan interpretations by five independent electronically trained readers were compared with measures....
Patients with amnestic mild cognitive impairment (aMCI) may progress to clinical Alzheimer disease (AD), remain stable, or revert normal. Earlier progression AD among patients who were β-amyloid positive vs those negative has been previously observed. Current research now accepts that a combination of biomarkers could provide greater refinement in the assessment risk for progression.To evaluate ability flutemetamol F 18 and other assess from aMCI probable AD.In this multicenter cohort study,...
The clinical diagnosis of dementia with Lewy bodies (DLB) depends on identifying significant cognitive decline accompanied by core features parkinsonism, visual hallucinations, fluctuations, and REM sleep behavior disorder (RBD). Hyposmia is one the several supportive features. α-Synuclein seeding amplification assays (αSyn-SAAs) may enhance diagnostic accuracy detecting pathologic αSyn seeds in CSF. In this study, we examine how different associate CSF αSyn-SAA positivity a large group...
Facial expression may be a surrogate marker of pain in Alzheimer disease (AD) when self-report is compromised. Recent studies have demonstrated increased sensitivity AD; however, experimental analyzing facial expressions AD are limited and report inconsistent results. The aims this study were to examine patients its relationship sum-scored measures multiple behavioral domains subjective ratings.The Action Coding System (FACS) was used characterize 35 33 healthy seniors during pressure...
Trajectories of cognitive decline vary considerably among individuals with mild impairment (MCI). To address this heterogeneity, subtyping approaches have been developed, the objective identifying more homogeneous subgroups. date, MCI has based primarily on measures, often resulting in indistinct boundaries between subgroups and limited validity. Here, we introduce a method for solely upon brain atrophy. We train deep learning model to differentiate Alzheimer's disease (AD) cognitively...
Alzheimer's disease (AD) is a serious neurodegenerative disorder without clear understanding of pathophysiology. Recent experimental data have suggested neuronal excitation-inhibition (E-I) imbalance as an essential element AD pathology, but E-I has not been systematically mapped out for either local or large-scale circuits in AD, precluding precise targeting treatment. In this work, we apply Multiscale Neural Model Inversion (MNMI) framework to the resting-state functional MRI from Disease...
Abstract Background Therapeutic development for frontotemporal dementia (FTD) is hindered by the lack of biomarkers that inform susceptibility/risk, prognosis, and underlying causative pathology. Blood glial fibrillary acidic protein (GFAP) has garnered attention as a FTD biomarker. However, investigations GFAP in have been hampered symptomatic histopathologic heterogeneity small cohort sizes contributing to inconsistent findings. Therefore, we evaluated plasma biomarker compared its...
Context: Research involving persons with impaired decision-making capacity (such as Alzheimer disease [AD]) remains ethically challenging, especially when the research involves significant risk.If individuals incapable of consenting to studies were able appoint a proxy, it would allow for an appointed surrogate (rather than de facto surrogate) represent subject.