A5031392944- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Advanced MRI Techniques and Applications
- Neurobiology and Insect Physiology Research
- Advanced Chemical Sensor Technologies
- EEG and Brain-Computer Interfaces
- Receptor Mechanisms and Signaling
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Biochemical Analysis and Sensing Techniques
- Mental Health Research Topics
- Cognitive Abilities and Testing
- Nicotinic Acetylcholine Receptors Study
- Photoreceptor and optogenetics research
- Stress Responses and Cortisol
- Neuroscience and Neural Engineering
- Anatomy and Medical Technology
- stochastic dynamics and bifurcation
- Glioma Diagnosis and Treatment
- Orthodontics and Dentofacial Orthopedics
- Nonlinear Dynamics and Pattern Formation
- Circadian rhythm and melatonin
University of North Carolina at Chapel Hill
2016-2025
Imaging Center
2019-2025
Cornell University
2011-2024
University of Missouri
2006-2008
Odor stimulation evokes rhythmic gamma oscillations in the field potential of olfactory bulb, but dynamical mechanisms governing these have remained unclear. Establishing is important as they determine biophysical capacities bulbar circuit to, for example, maintain zero-phase coherence across a spatially extended network, or coordinate timing action potentials principal neurons. These properties turn constrain and suggest hypotheses sensory coding.
Cholinergic inputs from the basal forebrain regulate multiple olfactory bulb (OB) functions, including odor discrimination, perceptual learning, and short-term memory. Previous studies have shown that nicotinic cholinergic receptor activation sharpens mitral cell chemoreceptive fields, likely via intraglomerular circuitry. Muscarinic is less well understood, though muscarinic receptors are implicated in learning regulation of synchronized oscillatory dynamics hippocampus cortex. To...
Abstract Major depressive disorder (MDD) is a serious mental illness characterized by dysfunctional connectivity among distributed brain regions. Previous connectome studies based on functional magnetic resonance imaging (fMRI) have focused primarily undirected and existing directed effective (EC) concerned mostly task‐based fMRI incorporated only few To overcome these limitations understand whether MDD mediated within‐network or between‐network connectivities, we applied spectral dynamic...
Abstract Brain wiring redundancy counteracts aging‐related cognitive decline by reserving additional communication channels as a neuroprotective mechanism. Such mechanism plays potentially important role in maintaining function during the early stages of neurodegenerative disorders such Alzheimer's disease (AD). AD is characterized severe and involves long prodromal stage mild impairment (MCI). Since MCI subjects are at high risk converting to AD, identifying individuals essential for...
The basolateral amygdala plays an important role in the acquisition and expression of both fear conditioning extinction. To understand how a single structure could encode these "opposite" memories, we developed biophysical network model lateral (LA) neurons during auditory Membrane channel properties were selected to match waveforms firing pyramidal cells interneurons LA, from published vitro studies. Hebbian plasticity was implemented excitatory AMPA inhibitory GABA(A) receptor-mediated...
The olfactory bulb transforms not only the information content of primary sensory representation, but also its underlying coding metric. High-variance, slow-timescale odor representations are transformed by bulbar circuitry into secondary based on principal neuron spike patterns that tightly regulated in time. This emergent fast timescale for signaling is reflected gamma-band local field potentials, presumably serving to efficiently integrate temporally networks central nervous system. To...
The functional connectome fingerprint is a cluster of individualized brain connectivity patterns that are capable distinguishing one individual from others. Although its existence has been demonstrated in adolescents and adults, whether such exist during infancy barely investigated despite importance identifying the origin intrinsic potentially mirror distinct behavioral phenotypes. To fill this knowledge gap, capitalizing on longitudinal high-resolution structural resting-state MRI dataset...
Alzheimer's disease (AD) is a serious neurodegenerative disorder without clear understanding of pathophysiology. Recent experimental data have suggested neuronal excitation-inhibition (E-I) imbalance as an essential element AD pathology, but E-I has not been systematically mapped out for either local or large-scale circuits in AD, precluding precise targeting treatment. In this work, we apply Multiscale Neural Model Inversion (MNMI) framework to the resting-state functional MRI from Disease...
Intercalated (ITC) amygdala neurons regulate fear expression by controlling impulse traffic between the input (basolateral amygdala; BLA) and output (central nucleus; Ce) stations of for conditioned responses. Previously, stimulation infralimbic (IL) cortex was found to reduce responsiveness Ce BLA inputs. These effects were hypothesized result from activation ITC cells projecting Ce. However, inhibit each other, leading question how IL inputs could overcome inter-ITC inhibition responses...
The thalamus plays a critical role in the genesis of thalamocortical oscillations, yet underlying mechanisms remain elusive. To understand whether isolated can generate multiple distinct we developed biophysical thalamic model to test hypothesis that generation and transition between oscillations be explained as function neuromodulation by acetylcholine (ACh) norepinephrine (NE) afferent synaptic excitation. Indeed, exhibited four rhythms (delta, sleep spindle, alpha gamma oscillations) span...
Major depressive disorder (MDD) represents a grand challenge to human health and society, but the underlying pathophysiological mechanisms remain elusive. Previous neuroimaging studies have suggested that MDD is associated with abnormal interactions dynamics in two major neural systems including default mode - salience (DMN-SAL) network executive limbic (EXE-LIM) network, it not clear which plays central role subordinate pathophysiology. To address this question, we refined newly developed...
Human brain undergoes rapid growth during the first few years of life. While previous research has employed graph theory to study early development, it mostly focused on topological attributes whole brain. However, examining regional graph-theory features may provide unique insights into development cognitive abilities. Utilizing a large and longitudinal rsfMRI dataset from UNC/UMN Baby Connectome Project, we investigated developmental trajectories efficiency evaluated relationships between...
Olfactory bulb granule cells are modulated by both acetylcholine (ACh) and norepinephrine (NE), but the effects of these neuromodulators have not been clearly distinguished. We used detailed biophysical simulations cells, alone embedded in a microcircuit with mitral to measure distinguish ACh NE on cellular function. Cholinergic noradrenergic modulatory were based data obtained from slice experiments; specifically, reduced conductance densities potassium M current calcium-dependent current,...
Abstract Spike timing-based representations of sensory information depend on embedded dynamical frameworks within neuronal networks that establish the rules local computation and interareal communication. Here, we investigated properties olfactory bulb circuitry in mice both sexes using microelectrode array recordings from slice vivo preparations. Neurochemical activation or optogenetic stimulation afferents evoked persistent gamma oscillations field potential. These arose slower, GABA(A)...
Olfactory bulb periglomerular (PG) cells are heterogeneous with respect to several features, including morphology, connectivity, patterns of protein expression, and electrophysiological properties. However, these features rarely correlate one another, suggesting that the differentiating properties PG may arise from multiple independent adaptive variables rather than representing discrete cell classes. We use computational modeling assess this hypothesis Specifically, we show demonstrated in...
Rhythmic brain stimulation has emerged as a powerful tool to modulate cognition and target pathological oscillations related neurological psychiatric disorders. However, we lack systematic understanding of how periodic interacts with endogenous neural activity function the state target.To address this critical issue, applied unified biophysical thalamic network model that generates multiple distinct oscillations, examined thoroughly impact rhythmic on different oscillatory states.We found...
Abstract Alzheimer’s disease (AD) is a serious neurodegenerative disorder without clear understanding of the etiology and pathophysiology. Recent experimental data has suggested neuronal excitation-inhibition (E-I) imbalance as an essential element critical regulator AD pathology, but E-I not been systematically mapped out for either local or large-scale circuits in AD. By applying Multiscale Neural Model Inversion (MNMI) framework to resting-state functional MRI (rs-fMRI) from Disease...