Steve Guofang Shen

ORCID: 0000-0001-7550-9459
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About
Contact & Profiles
Research Areas
  • Orthodontics and Dentofacial Orthopedics
  • Facial Trauma and Fracture Management
  • Dental Radiography and Imaging
  • Craniofacial Disorders and Treatments
  • Cleft Lip and Palate Research
  • Anatomy and Medical Technology
  • Dental Implant Techniques and Outcomes
  • 3D Shape Modeling and Analysis
  • Temporomandibular Joint Disorders
  • Facial Nerve Paralysis Treatment and Research
  • Bone Tissue Engineering Materials
  • Facial Rejuvenation and Surgery Techniques
  • Head and Neck Surgical Oncology
  • Medical Imaging and Analysis
  • Reconstructive Facial Surgery Techniques
  • Oral and Maxillofacial Pathology
  • Electrospun Nanofibers in Biomedical Applications
  • Spinal Fractures and Fixation Techniques
  • Mesenchymal stem cell research
  • Tracheal and airway disorders
  • Dental materials and restorations
  • Bone Tumor Diagnosis and Treatments
  • Traumatic Ocular and Foreign Body Injuries
  • Face recognition and analysis
  • Orthopedic Surgery and Rehabilitation

Shanghai University
2025

Shanghai Jiao Tong University
2014-2024

Shanghai Ninth People's Hospital
2014-2024

China-Japan Friendship Hospital
2024

National Clinical Research Center for Digestive Diseases
2020-2024

National Clinical Research
2019-2022

Shanghai University of Medicine and Health Sciences
2020-2022

Chinese Academy of Medical Sciences & Peking Union Medical College
2022

Science and Technology Commission of Shanghai Municipality
2022

Stomatology Hospital
2019

Surface modifications play an important role in endowing implant surface with excellent biocompatibility and bioactivity. Among the bioinspired modifications, mussel-inspired polydopamine (PDA) has aroused great interest of researchers. Herein, we fabricated PDA on diverse surfaces, including biopolymer, biometal, bioceramic. Then effects coating cell responsive behaviors vitro bone formation capacity vivo were evaluated detail. The results showed that was samples successfully, which could...

10.1021/acsami.8b21558 article EN ACS Applied Materials & Interfaces 2019-01-28

Abstract The role of neutrophils in bone regeneration remains elusive. In this study, it is shown that intramuscular implantation interleukin‐8 (IL‐8) (commonly recognized as a chemotactic cytokine for neutrophils) at different levels lead to outcomes resembling those fracture hematoma various stages. Ectopic endochondral ossification induced by certain IL‐8, during which are recruited the implanted site and N2‐polarized, then secrete stromal cell‐derived factor‐1 α (SDF‐1 ) mesenchymal stem...

10.1002/advs.202100584 article EN cc-by Advanced Science 2021-08-11

Genetic studies have revealed a critical role of Distal-homeobox (Dlx) genes in bone formation, and our previous study showed that Dlx2 overexpressing neural crest cells leads to profound abnormalities the craniofacial tissues. The aim this was investigate underlying molecular mechanisms osteogenic differentiation mouse marrow stromal (BMSCs) pre-osteoblast MC3T3-E1 cells. Initially, we observed upregulation during early osteogenesis BMSCs Moreover, overexpression enhanced alkaline...

10.1038/s41368-019-0046-1 article EN cc-by-nc-nd International Journal of Oral Science 2019-03-18

Purpose: Cone‐beam computed tomography (CBCT) is an increasingly utilized imaging modality for the diagnosis and treatment planning of patients with craniomaxillofacial (CMF) deformities. Accurate segmentation CBCT image essential step to generate three‐dimensional (3D) models CMF However, due poor quality, including very low signal‐to‐noise ratio widespread artifacts such as noise, beam hardening, inhomogeneity, it challenging segment images. In this paper, authors present a new automatic...

10.1118/1.4868455 article EN Medical Physics 2014-03-25

Most trauma surgeons encounter numerous penetrating injuries. Some foreign bodies can cause pain, infection, and discomfort to the patient. Serious functional disorders also are likely occur. Foreign in critical areas must be removed. This report describes use of image-guided technology for removal deep maxillofacial region.From 2008 through 2011, 5 patients with area underwent at authors' department. The STN navigation system (Stryker-Leibinger, Freiburg, Germany) was used surgical planning...

10.1016/j.joms.2013.04.001 article EN cc-by Journal of Oral and Maxillofacial Surgery 2013-06-27

The surgery-first approach (SFA), without presurgical orthodontic treatment, has become favoured in the treatment of dentomaxillofacial deformities. This been applied our institution since 2012. purpose this study was to report experience with SFA for skeletal malocclusion. Fifty patients malocclusions were enrolled (11 bimaxillary protrusion, 27 class III malocclusion, and 12 facial asymmetry). After orthognathic-orthodontic consultation, suitability determined a plan drawn up. Patients...

10.1016/j.ijom.2015.05.024 article EN cc-by-nc-nd International Journal of Oral and Maxillofacial Surgery 2015-11-14

Abstract Macrophages play an important role in material-related immune responses and bone formation, but the functionality of macrophage-derived extracellular vesicles (EVs) material-mediated regeneration is still unclear. Here, we evaluated intracellular communication through small (sEVs) its effects on endogenous mediated by biomimetic intrafibrillarly mineralized collagen (IMC). After implantation defect area, IMC generated more neobone recruited mesenchymal stem cells (MSCs) than did...

10.1038/s41368-020-00100-6 article EN cc-by International Journal of Oral Science 2020-11-30

Orthognathic surgical outcomes rely heavily on the quality of planning. Automatic estimation a reference facial bone shape significantly reduces experience-dependent variability and improves planning accuracy efficiency. We propose an end-to-end deep learning framework to estimate patient-specific bony models for patients with orthognathic deformities. Specifically, we apply point-cloud network learn vertex-wise deformation field from patient's deformed shape, represented as point cloud. The...

10.1109/jbhi.2021.3054494 article EN IEEE Journal of Biomedical and Health Informatics 2021-01-26

Promoting diabetic wound healing is still a challenge, and angiogenesis believed to be essential for healing. Vermiculite natural clay material that very easy obtain exhibits excellent properties of releasing bioactive ions, buffering pH, adsorption, heat insulation. However, there are many unsolved difficulties in obtaining two-dimensional vermiculite using it the biomedical field suitable form.In this study, we present versatile organic-inorganic composite scaffold, which was constructed...

10.1186/s12951-022-01556-w article EN cc-by Journal of Nanobiotechnology 2022-07-26

In the course of manual reduction distal radius fractures, many doctors rely on tactile perception to assess displacement fracture. However, a more accurate determination severity fracture and success requires measurement software annotate images, which is difficult achieve real-timely in actual procedure reduction. Which may lead misdiagnosis when experienced their intuition. Therefore, it necessary develop an AI-based method for calculating parameters provide real-time display,...

10.3389/fbioe.2025.1502669 article EN cc-by Frontiers in Bioengineering and Biotechnology 2025-02-19

Patients suffering from facial paralysis are on the hazard of disfigurement and loss vision due to blink function. Functional-electrical stimulation (FES) is one possible way restoring other functions in these patients. A restoration system for uni-lateral paralyzed patients described this paper. The achieves synchronized through processing myoelectric signal orbicularis oculi at normal side real-time as trigger stimulate eyelid. Design issues discussed, including EMG processing, stimulating...

10.1109/tbcas.2013.2255051 article EN IEEE Transactions on Biomedical Circuits and Systems 2013-04-01
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