A5100650012- Health Systems, Economic Evaluations, Quality of Life
- Immune Response and Inflammation
- Osteoarthritis Treatment and Mechanisms
- Biomedical Ethics and Regulation
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes Treatment and Management
- Fungal Infections and Studies
- Fungal Biology and Applications
- CAR-T cell therapy research
- Biomedical and Engineering Education
- Asthma and respiratory diseases
- Neurological Disease Mechanisms and Treatments
- Antifungal resistance and susceptibility
- Microbial Natural Products and Biosynthesis
- Wound Healing and Treatments
- Rheumatoid Arthritis Research and Therapies
- Advanced Glycation End Products research
- COVID-19 Clinical Research Studies
- Acupuncture Treatment Research Studies
- Pharmaceutical Economics and Policy
- Ferroptosis and cancer prognosis
- Dendrimers and Hyperbranched Polymers
- Spinal Cord Injury Research
- Gout, Hyperuricemia, Uric Acid
Aix-Marseille Université
2019-2025
Changchun University of Chinese Medicine
2025
Shanghai Tenth People's Hospital
2024
Tongji University
2024
Wenzhou Medical University
2024
Chinese Academy of Sciences
2024
Shenyang Pharmaceutical University
2023-2024
Institute of Microbiology
2024
Purdue University West Lafayette
2023
Nantong University
2021-2023
To meet the progressive requirements of advanced engineering materials with superior physicochemical performances, self-healing and injectable hydrogels (AD hydrogels) based on agarose pH-response were prepared through dynamic covalent Schiff-base linkages by simply mixing nontoxic agarose–ethylenediamine conjugate (AG-NH2) dialdehyde-functionalized polyethylene glycol (DF-PEG) solutions. The capabilities without any external stimulus are ascribed to between aldehyde groups DF-PEG amine...
This study aimed to investigate the critical factors for reimbursement decisions of innovative medicines in Scotland and explore feasibility machine learning models predicting decisions. All appraisals issued by Scottish Medicines Consortium (SMC) from 2016 2020 were screened extract decision outcomes 24 explanatory factors. SelectKBest with chi-square test was used factor selection. The P-value <0.05 considered have statistically significant associations selected. Six including tree, random...
Background: The antibiotic meropenem is commonly administered in patients with severe sepsis and septic shock. We compared the pharmacokinetic, clinical, bacteriological efficacies of continuous infusion versus intermittent administration such patients. Methods: Patients admitted to Intensive Care Unit (ICU) or shock who received were randomly assigned either (n = 25) groups 25). group a loading dose 0.5 g followed by 3 g/day; an initial 1.5 1 for every 8 h. Clinical success, microbiological...
Background The direct association between Parkinson's disease (PD) and Myocardial infarction (MI) has been the subject of relatively limited research. Objective purpose this study was to identify genes most associated with PD MI explore their common pathogenesis. Methods gene expression profiles were downloaded from GEO database. Differential analysis performed differential (DEGs) MI, followed by functional annotation. Subsequently, protein-protein interaction network constructed, hub DEGs...
Abstract Objectives To explore the feasibility of Ultra-short echo time (UTE) – MRI quantitative imaging in detecting early cartilage degeneration vivo and underlying pathological biochemical basis. Methods Twenty volunteers with osteoarthritis (OA) planning for total knee arthroplasty (TKA) were prospectively recruited. UTE-MRI sequences conventional performed preoperatively. Regions interests (ROIs) manually drawn on tibial plateau lateral femoral condyle images to calculate values....
In our previous study, coumarin-containing CYP51 inhibitor A32 demonstrated potent antiresistance activity. However, compound unsatisfied metabolic stability, necessitating modifications to overcome these limitations. this α,β-unsaturated amides were used replace the unstable coumarin ring, which increased stability by four times while maintaining antifungal activity, including activity against resistant strains. Subsequently, sterol composition analysis and morphological observation...
Achyranthes bidentata polypeptide fraction k (ABPPk) has been shown to protect ischemic stroke and Parkinson's disease, can inhibit neuroinflammation in lipopolysaccharide (LPS)-activated BV2 microglia. However, the effect of ABPPk responsible for alleviating microglial neurotoxicity remains unknown.Primary microglia were cultured investigate on LPS-induced neuroinflammation. Microglia conditioned medium (MCM) was collected stimulate primary cortical neurons then neuronal viability, lactate...
The precise physiological mechanisms of acupuncture in the treatment depression are still unknown. This study aimed to observe effects electroacupuncture (EA) on depression-like behavior mouse chronic mild stress (CMS) model and explore underlying mechanism.The was established by using CMS method for 6 weeks. After third week paradigm, EA performed daily 15 min over a period 3 antidepressant-like were evaluated sucrose preference test forced swimming (FST). protein levels nuclear...
Abstract Purpose To explore the palliative care needs and preferences of older adults with advanced or serious chronic illnesses their families. Also, to propose strategies promote supportive in rural communities Indiana, USA. Method We conducted qualitative interviews gather caregivers’ experiences care. Recruitment was done collaboration community partners using social media, flyers, emails, invitations, word‐of‐mouth. A purposive sample family caregivers obtained. All were online. The...
Preclinical Research & Development The purpose of the present study is to evaluate neuroprotective effect recombinant human glucagon‐like peptide‐1 (rhGLP‐1) as well explore corresponding mechanisms in diabetic rats with cerebral ischemia/reperfusion injury induced by middle artery occlusion (MCAO). Diabetes mellitus was intraperitoneal injection streptozotocin. were pretreated rhGLP‐1 (20 μg/kg intraperitoneally, thrice a day) for 14 days. Thereafter, subjected MCAO 90 min/reperfusion...
Abstract Preclinical Research The aim of the present study was to evaluate neuroprotective benefits rhGLP‐1 in diabetic rats subjected acute cerebral ischemia/reperfusion injury induced by middle artery occlusion/reperfusion (MCAO/R). Streptozotocin (STZ)‐induced were pretreated with (10, 20, or 40 μg/kg ip, tid) for 14 days. During this time, body weight and fasting blood glucose levels assessed. Rats then MCAO 90 min/R 24 h. At 2 h reperfusion, evaluated neurological deficits samples...
The secretion of Muc5ac is closely related to the pathogenesis, treatment and prognosis bronchial asthma. Atmospheric PM2.5 entered airway can irritate corrode wall, affecting expression Muc5ac. However, underlying mechanism not clear. In this study, we investigated role Notch signaling pathway in mucin section induced by atmospheric rats.Fifty rats were divided randomly into five groups: control received physiological saline; health, health inhibition asthma, asthma groups 7.5 mg/kg PM2.5....
Background. Aromatase inhibitors (AIs) are used for adjuvant therapy of breast cancer; however AIMSS (AI-Associated Musculoskeletal Symptoms) can negatively affect quality life and compliance. Most patients in China moved to TCM (traditional Chinese medicine) help. TB (tiger bone) is treat bone disease, whose main ingredients calcium collagen. The objective this study was evaluate whether the prevented postmenopausal women with ER/PR+ cancer. Methods. We conducted a randomized, blind,...
Neuroinflammation plays a crucial role in neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s (PD), anti-inflammation has been considered potential therapeutic strategy. Achyranthes bidentate polypeptide fraction k (ABPPk) was shown to protect neurons from death suppress microglia astrocyte activation PD model mice. However, how ABPPk regulates neuroinflammation exert neuroprotective remains unclear. Toxic Aβ oligomers (AβOs) can trigger inflammatory response play an...