A5100749404- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Wound Healing and Treatments
- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Pregnancy and preeclampsia studies
- Immune Response and Inflammation
- Immune cells in cancer
- Neurological Disease Mechanisms and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Oil and Gas Production Techniques
- Spinal Cord Injury Research
- Cancer-related gene regulation
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Antiplatelet Therapy and Cardiovascular Diseases
- Tryptophan and brain disorders
- Lysosomal Storage Disorders Research
- RNA Research and Splicing
- Cellular transport and secretion
- Smart Systems and Machine Learning
- 14-3-3 protein interactions
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
Dazhou Central Hospital
2025
Nantong University
2011-2023
Henan Provincial People's Hospital
2016-2023
Zhengzhou University
2016-2023
Soochow University
2018-2023
First Affiliated Hospital of Soochow University
2023
Henan University
2021
Huazhong University of Science and Technology
2007-2016
China University of Petroleum, Beijing
2013
Significance Here, we report that the long noncoding RNA (lncRNA) ovarian adenocarcinoma-amplified lncRNA (OVAAL) is a mediator of cancer cell resistance, counteracting effects apoptosis-inducing agents acting through both extrinsic and intrinsic pathways. Building upon previous reports associating OVAAL amplification with endometrial cancers, now show overexpression occurs during pathogenesis colorectal melanoma. Mechanistically, our findings also establish expression more generally...
Abstract Myelin biogenesis is a complex process involving coordinated exocytosis, endocytosis, mRNA transport, and cytoskeletal dynamics. Although abnormalities of myelin are common in lysosomal storage diseases, our understanding the role lysosomes formation maintenance still limited. Here, we show that late endosomes/lysosomes Schwann cells contain abundant protein P0, which accounts for over half total compact peripheral nervous system exhibit Ca 2+ ‐dependent exocytosis response to...
Mucormycosis is a life-threatening fungal infection with high mortality in critically ill patients. Clinical manifestations and outcomes of mucormycosis intensive care units (ICUs) remain poorly investigated. We conducted multicenter retrospective study including 43 adult patients confirmed admitted to 14 tertiary ICUs between January 2014 May 2022. characteristics, diagnostic approaches, treatment strategies, were analysed. The mean age was 56.8 ± 16.2 years, 16/43 (37.2%) female 28-day...
Renal cell carcinoma (RCC) has the highest mortality rate among urological cancers and tumor angiogenesis that plays a critical role in RCC progress. Epidermal growth factor-like domain multiple 7 (EGFL7) been recently identified as regulator progression. Long noncoding RNA (LncRNA) HOTAIR considered pro-oncogene cancers, but its precise mechanism of rarely reported. MicroRNA-126 (miR-126) functions suppressor RCC. However, underlying HOTAIR/miR-126 axis not studied. The proliferation,...
We have previously shown that Achyranthes bidentata polypeptides (ABPP), isolated from Blume (a medicinal herb), exhibit neurotrophic and neuroprotective effects on the nervous system. To identify major active component of ABPP, thus optimize use we used reverse-phase high performance liquid chromatography to separate ABPP. obtained 12 fractions, among which fraction ABPPk demonstrated strongest neuroactivity. Immunocytochemistry western blot analysis showed promoted neurite growth in...
Achyranthes bidentata polypeptide fraction k (ABPPk) has been shown to protect ischemic stroke and Parkinson's disease, can inhibit neuroinflammation in lipopolysaccharide (LPS)-activated BV2 microglia. However, the effect of ABPPk responsible for alleviating microglial neurotoxicity remains unknown.Primary microglia were cultured investigate on LPS-induced neuroinflammation. Microglia conditioned medium (MCM) was collected stimulate primary cortical neurons then neuronal viability, lactate...
After peripheral nerve injury, immune/inflammatory responses are triggered, which critical for regeneration. Despite their importance, the underlying molecular changes in remain largely unknown. In this study, we systematically analyzed differentially expressed genes immune/inflammatory-related pathways at high temporal resolution and experimentally validated gene expression with RT-PCR following sciatic crush rats. We found that reactions not only occur acute injury but also remained...
Activated microglia play a critical role in regulating neuroinflammatory responses central nervous system. Previous studies have shown that Achyranthes bidentata polypeptide k's (ABPPk's) neuroprotective effects are partly due to its anti-inflammatory effect, but the mechanism remains unknown. This study is aimed investigate effect of ABPPk on lipopolysaccharide (LPS)-activated neuroinflammation BV2 microglia.We pretreated with different concentrations (0.04-5 µg/mL) for 30 minutes, and then...
Inflammation dysregulation in placenta is implicated the pathogenesis of numerous pregnancy complications. Glucocorticoids (GCs), universally considered anti-inflammatory, can also exert proinflammatory actions under some conditions, whereas whether and how GCs promote placental inflammation have not been intensively investigated. In this paper we report opposing regulation rat by synthetic GC dexamethasone (Dex). When Dex was subcutaneously injected 1 h after administered an intraperitoneal...
Achyranthes bidentata polypeptide k (ABPPk), a powerful active component from traditional Chinese medicinal herb-Achyranthes Bl., has exhibited promising neuroprotective activity due to its multiple-targeting capability. However, the effect of ABPPk on survival, growth and axonal regeneration spinal cord motor neurons remains unclear. Here, modified method, which is more optimized for embryonic cells in ambient carbon dioxide levels, was used acquisition rat with high survival purity....
Abstract Objectives Artificial dermal scaffold (ADS) has undergone rapid development and been increasingly used for treating skin wound in clinics due to its good biocompatibility, controllable degradation, low risk of disease infection. To obtain treatment efficacy, ADS needs be monitored longitudinally during the process. For example, scaffold‐tissue fit, cell in‐growth, vascular regeneration, degradation are key properties inspected. However, date, there no effective, real‐time,...
Nowadays most heavy oil reservoirs are developed by thermal recovery methods, such as steam huff - puff and flooding. At the late stage of drive, because overlap in upper reservoir formation, channeling can easily occur production well. The research has shown that development effect nitrogen compound drive is not good consideration after channeling. But injecting water slug decrease For increasing phase saturation high permeability channel, gas relative will decrease. As result, it enlarge...
Abstract Background Ubiquitin-specific proteases (USPs) play a vital role in the modulation of protein trafficking and degradation through deubiquitination. It was reported that there is strong correlation ubiquitin-specific protease 2 (USP2) expression with apoptosis inflammation. Nonetheless, USP2 alleviating depression remains unclear, no therapeutic strategies targeting to treat have been reported. Methods The forced swim test (FST) tail suspension (TST) were performed investigate...
With the development of birthing-process medical science, and insurance requirement prepotency, ultrasound technique is widely used in application obstetrics realm, especially on monitoring embryo's growth. In recent decade, introduction high resolution three-dimensional ultrasonic color power Doppler scanner provides a much more direct, sensitive, forerunner method for embryo gravida's prediction. A novel that depends examining images vasculature placenta to determine growth introduced this...