A5103010181- Macrophage Migration Inhibitory Factor
- Cancer Research and Treatments
- Fatty Acid Research and Health
- Tryptophan and brain disorders
- Immune cells in cancer
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Phytoestrogen effects and research
- Energetic Materials and Combustion
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cancer, Lipids, and Metabolism
- Stress Responses and Cortisol
- Cancer, Hypoxia, and Metabolism
- Genetics and Neurodevelopmental Disorders
- Digestive system and related health
- Metabolomics and Mass Spectrometry Studies
- Treatment of Major Depression
- Thermal and Kinetic Analysis
- Rocket and propulsion systems research
First Affiliated Hospital of Zhengzhou University
2023-2024
Zhengzhou University
2023-2024
Abstract Recently discovered epigenetic modification lysine lactylation contributes to tumor development and progression in several types of cancer. In addition the tumor-intrinsic effects, histone may mediate microenvironment remodeling immune evasion. this study, we observed elevated pan–lysine H3 18 (H3K18la) levels non–small cell lung cancer (NSCLC) tissues, which was positively correlated with poor patient prognosis. Interruption glycolysis by 2-deoxy-D-glucose oxamate treatment...
Hypergolicity is a highly desired characteristic for hybrid rocket engine-based fuels because it eliminates the need separate ignition system. Introducing hypergolic additives into conventional through physical mixing feasible approach, but achieving reliable and energy release remains major challenge. Here, construction of core-shell Al@metal organic framework (MOF) heterostructures reported as high-performance solid propellants. Upon contact with liquid oxidizer uniformly distributed MOF...
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy with a rapidly increasing incidence. The pathogenesis of PTC unclear, but metabolic and lipidomic reprogramming may play role in tumor growth. We applied ultra-performance liquid chromatography-tandem mass spectrometry to perform widely targeted metabolomics lipidomics on plasma samples from 94 patients 100 healthy controls. identified 113 differential metabolites 236 lipids, mainly involved branched-chain amino acid...
Abstract Aims The study aimed to assess brain metabolite differences in the medial prefrontal cortex (mPFC) between acute and euthymic episodes of bipolar disorder (BD) with both mania depression over a 6‐month medication treatment period. Methods We utilized 1 H‐MRS technology levels 53 individuals BD (32 depressive phase, 21 manic phase) 34 healthy controls (HCs) at baseline. After 6 months treatment, 40 subjects underwent follow‐up scan state. Metabolite levels, including N‐acetyl...
<p>Supplementary Figures</p>
<div>Abstract<p>Recently discovered epigenetic modification lysine lactylation contributes to tumor development and progression in several types of cancer. In addition the tumor-intrinsic effects, histone may mediate microenvironment remodeling immune evasion. this study, we observed elevated pan–lysine H3 18 (H3K18la) levels non–small cell lung cancer (NSCLC) tissues, which was positively correlated with poor patient prognosis. Interruption glycolysis by 2-deoxy-D-glucose...
Abstract Background Ubiquitin-specific proteases (USPs) play a vital role in the modulation of protein trafficking and degradation through deubiquitination. It was reported that there is strong correlation ubiquitin-specific protease 2 (USP2) expression with apoptosis inflammation. Nonetheless, USP2 alleviating depression remains unclear, no therapeutic strategies targeting to treat have been reported. Methods The forced swim test (FST) tail suspension (TST) were performed investigate...