A5015717934- Cannabis and Cannabinoid Research
- Synthesis and Biological Evaluation
- Antifungal resistance and susceptibility
- Polyamine Metabolism and Applications
- Transgenic Plants and Applications
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
- Cholinesterase and Neurodegenerative Diseases
- Glycosylation and Glycoproteins Research
- Synthesis and biological activity
- Enzyme function and inhibition
- Phytochemical compounds biological activities
- Organoselenium and organotellurium chemistry
- Supramolecular Chemistry and Complexes
- Carbohydrate Chemistry and Synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Peptidase Inhibition and Analysis
- GABA and Rice Research
- Fungal Infections and Studies
- Chemical Synthesis and Analysis
- Plant Parasitism and Resistance
- Cancer Treatment and Pharmacology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Coconut Research and Applications
- RNA modifications and cancer
Yunnan Academy of Agricultural Sciences
2018-2024
Shenyang Pharmaceutical University
2016-2024
CAE (Canada)
2006
Yunnan University
2006
Cannabis is one of the most important industrial crops distributed worldwide. However, phylogeographic structure and domestication knowledge this crop remains poorly understood. In study, sequence variations five chloroplast DNA (cpDNA) regions were investigated to address these questions. For 645 individuals from 52 accessions sampled (25 wild populations 27 domesticated or cultivars), three haplogroups (Haplogroup H, M, L) identified lineages exhibited distinct high-middle-low latitudinal...
The extensive use of antifungal drugs has resulted in severe drug resistance, making clinical treatment fungal infections more difficult. Biofilm inhibitors can overcome resistance by inhibiting biofilm formation. In this study, some coumarins with antibiofilm activity were merged into CYP51 to produce novel molecules possessing potent antiresistance activity. As expected, most compounds exhibited excellent vitro against pathogenic fungi, especially fluconazole-resistant candidiasis. Then,...
A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, their structures were characterized HRMS, FTIR NMR. The in vitro antifungal activity target compounds evaluated using the microdilution broth method against five strains pathogenic fungi. result indicated that exhibited moderate to satisfactory activity. Furthermore, molecular docking performed investigate binding affinities interaction modes between compound N-myristoyltransferase. Based on...
RT-qPCR has been widely used for gene expression analysis in recent years. The accuracy of this technique largely depends on the selection suitable reference genes. In order to facilitate wild and cultivated Cannabis, stability seven candidate genes (ACT2, 18S rRNA, GAPDH, UBQ, TUB, PP2A EF1α) were assessed leaves samples different development stages organs both Cannabis present study. Their stabilities evaluated through three software packages (GeNorm, Normfinder Bestkeeper). Results showed...
In our previous study, coumarin-containing CYP51 inhibitor A32 demonstrated potent antiresistance activity. However, compound unsatisfied metabolic stability, necessitating modifications to overcome these limitations. this α,β-unsaturated amides were used replace the unstable coumarin ring, which increased stability by four times while maintaining antifungal activity, including activity against resistant strains. Subsequently, sterol composition analysis and morphological observation...
Abstract Background Cannabis is an important industrial crop species whose fibre, seeds, flowers and leaves are widely used by humans. The study of cannabinoids extracted from plants has been popular research topic in recent years. China one the origins cannabis few countries with wild plants. However, genetic structure Chinese degree adaptive selection remain unclear. Results main morphological characteristics were assessed. Based on whole-genome resequencing SNPs, could be divided into...
Summary of main observation and conclusion Benzofuran has antifungal activity as the inhibitor N‐myristoyltransferase. Twenty‐nine novel benzofuran‐semicarbazide hybrids were designed synthesized by principle drug combinationatory. On this basis, benzofuran ring was simplified to a resorcinol structure, sixteen 1,3‐dialkoxybenzene‐semicarbazide synthesized. All structures target compounds characterized HRMS NMR. The in vitro evaluated using microdilution broth method against eight strains...
Imines, versatile intermediates for organic synthesis, can be exploited the preparation of diverse classes biologically active benzazoles. Because special characteristics C=N bond, imines simultaneously used in synthesis 1,3-benzazoles and 1,2-benzazoles. With development imine a variety novel cascade reactions benzazole have been reported last decade. Therefore, there is strong need to elucidate recent progress formation various benzazoles, including benzimidazoles, benzoxazoles,...
A series of AA/BB types cyclodextrin‐based supramolecular polymers (CD‐SP 1, 2, 3, and 4) have been constructed characterized, which employed as ligands to accelerate the copper(I)‐catalyzed azide alkyne cycloaddition (CuAAC) using conventional Sharpless–Fokin catalyst (CuSO 4 + Na ascorbate) for first time. Among them, bridged‐maleic‐2‐β‐CD (CD = cyclodextrin)@bridged‐maleic‐2‐Ada (Ada adamantane) self‐assembly shows more effective catalytic activity CuAAC acetylene at 40 mol ppm Cu(I) in...
Abstract Macrocycles have garnered significant interest for their potential utility as supramolecular catalysts in modulating chemical transformations. Here, we report a reusable catalytic system to accelerate copper(I) catalyzed Click cycloaddition (CuAAC) reactions water. Our comprises of 5 mol % CuI and 0.5 the co‐catalyst, cucurbit[7]uril (CB7), which stabilizes prevents oxidation Cu I . This catalysis can be cycled is that triazole product or alkyne reactant hardly bind cavity CB7 while...