A5100694789- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Neural dynamics and brain function
- Acute Ischemic Stroke Management
- Obesity, Physical Activity, Diet
- EEG and Brain-Computer Interfaces
- Systemic Lupus Erythematosus Research
- Cardiac, Anesthesia and Surgical Outcomes
- Retinal Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Neurological Disorders and Treatments
- Sleep and related disorders
- Atherosclerosis and Cardiovascular Diseases
- Hip and Femur Fractures
- Mental Health Research Topics
- Parkinson's Disease Mechanisms and Treatments
- Advanced X-ray and CT Imaging
- COVID-19 Clinical Research Studies
- Learning Styles and Cognitive Differences
- Tryptophan and brain disorders
- Optical Imaging and Spectroscopy Techniques
- Medical Imaging and Analysis
- Maternal Mental Health During Pregnancy and Postpartum
Zhongda Hospital Southeast University
2013-2025
Third Affiliated Hospital of Guangzhou Medical University
2019-2025
Guangzhou Medical University
2019-2025
Sun Yat-sen University
2022
North China University of Science and Technology
2019
University of Pennsylvania
2017
Guangxi Medical University
2017
Guangdong Academy of Medical Sciences
2015-2016
Southeast University
2013-2016
National Institute on Drug Abuse
2016
Previous research has shown that type 2 diabetes mellitus (T2DM) is associated with an increased risk of cognitive impairment. Patients impaired cognition often show decreased spontaneous brain activity on resting-state functional magnetic resonance imaging (rs-fMRI). This study used rs-fMRI to investigate changes in among patients T2DM and determine the relationship these (n = 29) age-, sex-, education-matched healthy control subjects 27) were included this study. Amplitude low-frequency...
Type 2 diabetes is characterized by insulin resistance, which involved in the development of Alzheimer disease. This study aims to investigate relationship between abnormal resting-state brain functional connectivity and resistance type diabetes.A total 30 patients with 31 healthy well-matched volunteers were prospectively examined. Resting-state analysis was used examine correlation posterior cingulate cortex (PCC) whole-brain regions. The possible relationships measures evaluated using...
Type 2 diabetes mellitus is associated with increased risk for dementia. Patients impaired cognition often show default-mode network disruption. We aimed to investigate the integrity of a in diabetic patients by using independent component analysis, and explore relationship between abnormalities, neurocognitive performance variables. Forty-two type 42 well-matched healthy controls were included underwent resting-state functional MRI 3 Tesla unit. Independent analysis was adopted extract...
To explore the effect of T2DM on cerebral perfusion, and relationship between perfusion changes cognitive impairment as well diabetic variables, by using a whole-brain arterial spin-labeling (ASL) MRI technique. This prospective study was approved local institutional review board performed November 2012 October 2013. All subjects provided informed consent. Forty patients 41 age-, sex- education-matched healthy controls were included. Cerebral blood flow (CBF) map obtained pulsed ASL imaging...
Abstract Major depressive disorder (MDD) is a serious mental illness characterized by dysfunctional connectivity among distributed brain regions. Previous connectome studies based on functional magnetic resonance imaging (fMRI) have focused primarily undirected and existing directed effective (EC) concerned mostly task‐based fMRI incorporated only few To overcome these limitations understand whether MDD mediated within‐network or between‐network connectivities, we applied spectral dynamic...
Abstract Background The novel coronavirus 2019 (SARS-CoV-2) has caused wide dissemination across the world. Global health systems are facing unprecedented challenges. Here we shared experiences and lessons in emergency responses management from our hospital, a government-assigned regional anti-Covid-19 general hospital Nanjing, Jiangsu Province, China. Methods Our periodic strategies dealing with Covid-19 were described detail. An administrative response including establishment of Emergency...
Background: Major depressive disorder (MDD) is one of the most common and costly psychiatric disorders. In addition to significant changes in mood, MDD patients face an increased risk developing cognitive dysfunction. It important gain improved understanding impairments find a biomarker for impairment diagnosis MDD. Methods: One hundred 100 normal controls (NCs) completed resting-state fMRI (rs-fMRI) scan, which 34 NCs had scores multiple domains (executive function, verbal fluency,...
Type 2 diabetes is associated with an increased risk of dementia. This study investigated the global connectivity patterns in brains patients type by using a functional MR imaging technique.Forty and 43 age-, sex-, education-matched healthy controls underwent resting-state 3T unit. Degree centrality, commonly used measurement connectivity, was computed for full-brain exploration regions influenced diabetes. We then examined each region seed-based approach. Finally, voxelwise correlation...
“Just Accepted” papers have undergone full peer review and been accepted for publication in Radiology: Artificial Intelligence. This article will undergo copyediting, layout, proof before it is published its final version. Please note that during production of the copyedited article, errors may be discovered which could affect content. Purpose To develop evaluate a multilabel deep learning network to identify quantify acute chronic brain lesions on multisequence MRI after ischemic stroke...
The mechanistic role of insulin resistance(IR) between obesity and Depressive Symptoms has long been debated. This study aims to explore the relationship BMI investigate mediating IR in this association. We rigorously selected data from National Health Nutrition Examination Survey (NHANES) 2005 2018. Multivariate logistic regression analysis, Restricted cubic splines (RCS) Subgroup analysis were employed assess correlation Symptoms. Mediation was conducted examine Overweight/obesity After...
Post-stroke cognitive dysfunction greatly influences patients' quality of life after stroke. However, its neurophysiological basis remains unknown. This study utilized resting-state functional magnetic resonance imaging (fMRI) to investigate the alterations in regional coherence patients subcortical stroke.Resting-state fMRI measurements were acquired from 16 post-stroke with poor function (PSPC), good (PSGC) and 30 well-matched healthy controls (HC). Regional homogeneity (ReHo) was used...
Benzene is a ubiquitous pollutant and mainly accumulates in adipose tissue which has important roles metabolic diseases. The latest studies reported that benzene exposure was associated with many disorders, while the effect of on remains unclear. We sought to investigate using vivo vitro experiments. Male adult C57BL/6J mice were exposed at 0, 1, 10 100 mg/kg body weight by intragastric gavage for 4 weeks. Mature adipocytes from 3T3-L1 cells hydroquinone (HQ) 5 25 μM 24 hours. Besides...
To investigate mechanism-based anti-anxiety effects of Shudihuang (Radix Rehmanniae Preparata) polysaccharides (RRPPs) through two-dimensional electrophoresis (2-DE) analysis with mass spectrometry (MS) hippocampus proteins in rats treated monosodium L-glutamate (MSG). MSG (4 g/kg) or normal saline (NS) was injected subcutaneously into infant male on days 2, 4, 6, 8, 10 after birth. MSG-treated at 8 weeks old were given NS, diazepam, RRPPs daily for seven consecutive by intragastric...
Greater fish consumption is associated with improved cognition among children, but the mediating pathways have not been well delineated. Improved sleep could be a candidate mediator of fish-cognition relationship. This study assesses whether 1) more frequent less disturbances and higher IQ scores in schoolchildren, 2) such relationships are accounted for by social economic confounds, 3) quality mediates fish-IQ In this cohort 541 Chinese were assessed at age 9-11 years, while was 12....
Major depressive disorder (MDD) represents a grand challenge to human health and society, but the underlying pathophysiological mechanisms remain elusive. Previous neuroimaging studies have suggested that MDD is associated with abnormal interactions dynamics in two major neural systems including default mode - salience (DMN-SAL) network executive limbic (EXE-LIM) network, it not clear which plays central role subordinate pathophysiology. To address this question, we refined newly developed...
Objective Among adolescents with depression, the occurrence of non-suicidal self-injury (NSSI) behavior is prevalent, constituting a high-risk factor for suicide. However, there has been limited research on neuroimaging mechanisms underlying adolescent depression and NSSI behavior, potential association between two remains unclear. Therefore, this study aims to investigate alterations in functional connectivity (FC) regions prefrontal cortex whole brain, elucidates relationship these...
The use of thrombolysis in acute ischemic stroke is restricted to a small proportion patients because the rigid 4·5-h window. With advanced imaging-based patient selection strategy, rescuing penumbra critical improving clinical outcomes. In this study, we included 155 (84 training dataset, age from 43 80, 59 males; 71 validation 36 45 males) who underwent MR scan within first 9-h after onset, 7 independent centers. Based on mismatch concept, and core area were identified quantitatively...
Aurora kinase A (AURKA) is a serine threonine which affects chromosomal separation and mitotic spindle stability through interaction with the centrosome during mitosis. Two functional nonsynonymous polymorphisms of AURKA gene (Ile31Phe Val57Ile) have been reported recently. We analyzed association between two risk occurrence hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in Guangxi population consisting 348 patients HCC 359 control subjects, then validated significant...
Background Type 2 diabetes mellitus (T2DM) is associated with cognitive decline and altered brain structure function. However, the interhemispheric coordination of T2DM patients unclear. Purpose To investigate functional anatomic connectivity in T2DM, their associations performance endocrine parameters. Study Prospective. Subjects 38 42 matched controls. Field Strength/Sequences 3.0 T magnetic resonance imaging (MRI) scanner; magnetization‐prepared rapid acquisition gradient echo sequence;...