A5101853931- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Ischemia and Reperfusion
- Thermal Regulation in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- Anesthesia and Neurotoxicity Research
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- Gastrointestinal motility and disorders
- S100 Proteins and Annexins
- Respiratory Support and Mechanisms
- Trauma and Emergency Care Studies
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Mechanical Circulatory Support Devices
- SARS-CoV-2 and COVID-19 Research
- Neuroscience of respiration and sleep
- Emergency and Acute Care Studies
- Injury Epidemiology and Prevention
- Immune Response and Inflammation
- Tissue Engineering and Regenerative Medicine
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
Sun Yat-sen University
2014-2024
Third Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Jingdezhen Ceramic Institute
2024
Guangzhou University of Chinese Medicine
2018-2024
Sichuan University
2024
Guangdong Provincial Center for Disease Control and Prevention
2022-2024
Key Laboratory of Guangdong Province
2024
Chengde Medical University
2024
Guangzhou Center for Disease Control and Prevention
2024
SARS-CoV infection of human results in antigen-specific cellular and humoral immune responses. However, it is critical to determine whether SARS-CoV-specific memory T cells can persist for long periods time. In this study, we analyzed the response from 21 SARS-recovered individuals who had been diagnosed with SARS 2003 by using ELISA, CBA, ELISpot multiparameter flow cytometry assays. Our demonstrated that low levels specific cell responses S, M, E N peptides were detected a proportion...
Carbon monoxide (CO) has shown various physiological effects including anti-inflammatory activity in several diseases, whereas the therapeutic efficacy of CO on sepsis-induced acute kidney injury (AKI) not been reported as yet. The purpose present study was to explore exogenous AKI and nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activation rats. Male rats were subjected cecal ligation puncture (CLP) induce sepsis AKI. Exogenous delivered from CO-releasing molecule...
Background The non-pharmaceutical interventions (NPIs) against COVID-19 may have affected the transmission of hand, foot and mouth disease (HFMD). We aimed to assess impact NPIs on HFMD in high epidemic area HFMD, Guangdong Province. Methods data cases, etiological information, meteorological factors from January 1, 2012, December 31, 2021, were collected. Using a Bayesian structural time series (BSTS) model integrated counterfactual framework, we assessed effect by different intervention...
Cardiac arrest-induced global cerebral ischemia injury (CA-GCII) usually leads to a poor neurological outcome without an effective treatment. Bone marrow-derived mesenchymal stem cells (BMMSCs) may provide potential cell-based therapy against neurologic disorders through induction of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth (VEGF). To optimize the neuroprotective efficacy BMMSCs further, in this study we have derived BMMSCs, which co-overexpress both BDNF...
The etiology of diarrhea-predominant irritable bowel syndrome (IBS-D) is complicated and closely related to neurotransmission in the gastrointestinal (GI) tract. Developing new strategies for treating this disease a major challenge IBS-D research. Berberine hydrochloride (BBH), derivative berberine, herbal constituent used treat IBS. Previous studies have shown that BBH has potential anti-inflammatory, antibacterial, analgesic, antidiarrheal effects wide range biological activities,...
The membrane (M) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is a major glycoprotein with multiple biological functions. In this study, we found that memory T cells against M were persistent in recovered SARS patients by detecting gamma interferon (IFN-gamma) production using ELISA and ELISpot assays. Flow cytometric analysis showed both CD4+ CD8+ involved cellular responses to SARS-CoV antigen. Furthermore, displayed an effector cell phenotype expressing CD45RO-...
Empagliflozin is a newly developed antidiabetic drug to reduce hyperglycaemia by highly selective inhibition of sodium-glucose co-transporter 2. Hyperglycaemia commonly seen in patients after cardiac arrest (CA) and associated with worse outcomes. In this study, we examined the effects empagliflozin on function rats myocardial dysfunction CA. Non-diabetic male Sprague-Dawley underwent ventricular fibrillation induce CA, or sham surgery. Rats received 10 mg/kg vehicle at min return...
Mitochondrial dysfunction contributes to brain injury following global cerebral ischemia after cardiac arrest.Carbon monoxide treatment has shown potent cytoprotective effects in ischemia/reperfusion injury.This study aimed investigate the of carbon monoxide-releasing molecules on mitochondrial and resuscitation arrest rats.A rat model was established by asphyxia.The animals were randomly divided into 3 groups: group, plus intervention sham control group (no arrest).After return spontaneous...
ABSTRACT No pharmacological interventions are currently available to provide neuroprotection for patients suffering from cardiac arrest. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase inhibitor, which activates (PDH), and increases cell adenosine triphosphate (ATP) production by promoting influx of into the Krebs cycle. In this study, we investigated effects DCA on post-resuscitation neurological injury in an asphyxial arrest rat model. Asphyxial was established endotracheal tube...
Carbon monoxide (CO) is an endogenous gaseous transmitter that exerts multi-protection in ischemia/reperfusion (I/R) injury, but few experimental studies regarding CO on myocardial I/R-induced apoptosis, as well its underlying mechanism have been conducted. The present study was designed to investigate whether released from CO-releasing molecule-2 (CORM-2) capable of ameliorating apoptosis via a mitochondrial apoptotic pathway. Primary cultures neonatal rat cardiomyocytes were randomly...
Postcardiac arrest brain injury significantly contributes to mortality and morbidity in patients suffering from cardiac (CA). Evidence that shows mitochondrial dysfunction appears be a key factor tissue damage after ischemia/reperfusion is accumulating. However, limited data are available regarding the cerebral during CA cardiopulmonary resuscitation (CPR) its relationship alterations of high-energy phosphate. Here, we sought identify morphology oxidative phosphorylation function as well...
Objective: We investigated the effects of three different sites for delivery bone marrow mesenchymal stem cells (MSCs) in a rat model myocardial ischemia. Design: Prospective, randomized, controlled study. Setting: University affiliated research institute. Subjects: Male Sprague-Dawley rats. Interventions: A thoracotomy was performed under general anesthesia. Myocardial ischemia induced by ligation left anterior descending coronary artery. One month later, animals were randomized to receive...