A5048020632- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Neurological Disease Mechanisms and Treatments
- Clostridium difficile and Clostridium perfringens research
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neural Engineering
- Microbial infections and disease research
- Chronic Disease Management Strategies
- Milk Quality and Mastitis in Dairy Cows
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Stroke Rehabilitation and Recovery
- Amyotrophic Lateral Sclerosis Research
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Cholinesterase and Neurodegenerative Diseases
- Extracellular vesicles in disease
University of Copenhagen
2016-2025
Zealand University Hospital
2016-2025
Herlev Hospital
2024
Technical University of Denmark
2023
Rigshospitalet
1995-2023
Copenhagen University Hospital
2007-2023
Psychiatry Region Zealand
2016-2017
Roskilde Sygehus
2014-2016
Region Zealand
2015-2016
Danish Pain Research Center
2015
Background: Studies of physical exercise in patients with Alzheimer’s disease (AD) are few and results have been inconsistent. Objective: To assess the effects a moderate-to-high intensity aerobic program mild AD. Methods: In randomized controlled trial, we recruited 200 AD to supervised group (60-min sessions three times week for 16 weeks) or control group. Primary outcome was changed from baseline cognitive performance estimated by Symbol Digit Modalities Test (SDMT) intention-to-treat...
<i>Background:</i>The validity of dementia diagnoses in the Danish nationwide hospital registers was evaluated to determine value these epidemiological research about dementia. <i>Methods:</i> Two hundred patients were randomly selected from 4,682 registered for first time with a diagnosis last 6 months 2003. The patients’ medical journals reviewed evaluate if they fulfilled ICD-10 and/or DSM-IV criteria and specific subtypes. who still alive 2006 invited an...
Background: Quantitative EEG (qEEG) power could potentially be used as a diagnostic tool for Alzheimer’s disease (AD) and may further our understanding of the pathophysiology. However, early qEEG changes AD are not well understood. Objective: To investigate in possible correlation with memory function cerebrospinal fluid biomarkers. In addition, whether discriminate between AD, mild cognitive impairment (MCI), older healthy controls (HC) at individual level. Methods: Standard EEGs from 138...
Abstract Introduction Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated effect aerobic on physical performance in community‐dwelling mild disease. Methods The single blinded multi‐center RCT (ADEX) included 200 patients, median age 71 yrs (50‐89). intervention group received supervised moderate‐to‐high intensity 1 hour × 3/week for 16 weeks. Assessments cardiorespiratory fitness, single‐task performance,...
Neuroinflammation is recognized as part of the pathological progression Alzheimer's disease (AD), but molecular mechanisms are still not entirely clear. Systemically, physical exercise has shown to have a positive modulating effect on markers inflammation. It known if this general also takes place in central nervous system AD. The aim study was investigate 16 weeks moderate high-intensity selected biomarkers inflammation both systemically and CNS, patients with Plasma cerebrospinal fluid...
Abstract Background Neuron-derived extracellular vesicles (NDEVs) in blood may be used to derive biomarkers for the effects of exercise Alzheimer’s disease (AD). For this purpose, we studied changes neuroprotective proteins proBDNF, BDNF, and humanin plasma NDEVs from patients with mild moderate AD participating randomized controlled trial (RCT) ADEX. Methods were quantified immunocaptured 95 ADEX participants, into control groups, collected at baseline 16 weeks. Exploratorily, also NDEV...
To determine whether the APOE epsilon4 allele is associated with age-related intellectual decline in a community-dwelling sample of Danes.A 189 subjects who did not have dementia was tested Wechsler Adult Intelligence Scale (WAIS) at ages 50 and 80 years. Of these subjects, 163 (84 women 79 men) completed all WAIS subtests both assessments 139 digit symbol block design 50, 60, 70, years.Cognitive from age to years substantial larger for performance than verbal (the declines were 18.40 IQ...
To elucidate the importance of clinically diagnosed cerebral comorbidity in idiopathic normal-pressure hydrocephalus (INPH) and its effect on improvement after shunt surgery as well concordance with parenchymal pathological changes described frontal biopsy specimens.In 28 consecutive patients INPH shunted according to clinical, radiological cerebrospinal fluid dynamic criteria, concomitant disorders were carefully registered, special emphasis cerebrovascular disease (CVD) possible...
Patients with amnestic mild cognitive impairment (aMCI) may progress to clinical Alzheimer disease (AD), remain stable, or revert normal. Earlier progression AD among patients who were β-amyloid positive vs those negative has been previously observed. Current research now accepts that a combination of biomarkers could provide greater refinement in the assessment risk for progression.To evaluate ability flutemetamol F 18 and other assess from aMCI probable AD.In this multicenter cohort study,...
Network dysfunction is well established in patients with Alzheimer's disease (AD) and has been shown to be present early the disease. This especially interesting mild cognitive impairment (MCI) since they are more likely develop AD. In EEG, one type of network analysis microstates where EEG divided into quasi-stable states these have linked networks found resting state functional MRI. current exploratory study, we therefore wanted explore changes MCI, AD compared healthy controls (HC)...
Physical activity has the potential to improve physical function in patients with Alzheimer's disease (AD) and may contribute modify processes cognitive function.The aim of this study was investigate 1) effect moderate-high-intensity aerobic exercise on cardiorespiratory fitness, i.e., peak oxygen uptake (VO2peak) determined by direct breath-by-breath cardiopulmonary test, 2) association between changes VO2peak cognition neuropsychiatric symptoms mild AD.The is based secondary outcome...
Previous studies have shown an association between disruption of the blood-brain-barrier (BBB) and dementias different etiologies. The protein concentration cerebrospinal fluid (CSF) can be used as indirect measurement for permeability BBB using CSF/plasma albumin quotient (Q-Alb) or total CSF protein.In current study, we wanted to investigate Q-Alb in etiologies possible confounding factors.A 510 patients healthy controls were included study. diagnosed with Alzheimer's disease (AD),...
In patients with Alzheimer's disease (AD) without clinical seizures, up to half have epileptiform discharges on long-term in-patient electroencephalography (EEG) recordings. Long-term monitoring is obtrusive, and expensive as compared outpatient monitoring. No studies so far investigated if EEG able identify in AD. Our aim investigate measured ear-EEG are more common AD healthy elderly controls (HC).In this longitudinal observational study, 24 mild moderate 15 age-matched HC were included...
Recent studies suggested induction of 40 Hz neural activity as a potential treatment for Alzheimer's disease (AD). However, prolonged exposure to flickering light raises adherence and safety concerns, encouraging investigation tolerable stimulation protocols.To investigate the safety, feasibility, exploratory measures efficacy.This two-stage randomized placebo-controlled double-blinded clinical trial, recruited first cognitive healthy participants (n = 3/2 active/placebo), subsequently...
<b><i>Background:</i></b> Physical exercise may have some effect on cognition in patients with Alzheimer disease (AD). However, the underlying biochemical effects are unclear. Animal studies shown that amyloid beta (Aβ), one of pathological hallmarks AD, can be altered high levels physical activity. <b><i>Aim:</i></b> The objective this study was to elucidate 16 weeks moderate- high-intensity biomarkers special emphasis amyloidogenic pathway....
<b><i>Introduction:</i></b> The aim of this study was to examine if quantitative electroencephalography (qEEG) using the statistical pattern recognition (SPR) method could predict conversion dementia in patients with subjective cognitive decline (SCD) and mild impairment (MCI). <b><i>Methods:</i></b> From 5 Nordic memory clinics, we included 47 SCD patients, 99 MCI 67 healthy controls. EEGs analyzed SPR together clinical data recorded at...
Abstract Background Several factors may play a role in the ability of patients with Alzheimer’s disease to perform activities daily living (ADL). The aim this study was examine impact different aspects physical performance and cognitive functions on ADL suffering from mild-to-moderate disease. Methods We conducted secondary analyses cross-sectional baseline data randomized controlled multicentre “Preserving quality life, health functional Disease: effect exercise” (ADEX). In total, 185 AD...
Mild cognitive impairment (MCI) refers to mild objective deficits and is associated with later development of Alzheimer's disease (AD). However, not all patients MCI convert AD. EEG spectral power has shown promise as a marker progression but brain oscillations in different frequencies are isolated entities. Coupling between frequency bands so called cross coupling (CFC) been memory function may further contribute our understanding what characterizes who progress In the current study, we...
Abstract INTRODUCTION Early symptoms in young onset Alzheimer's disease (YOAD) may be misinterpreted, causing delayed diagnosis. This population‐based study aimed to map morbidity prior YOAD METHODS In a register‐based incidence density matched nested case‐control study, we examined hospital‐diagnosed for people diagnosed with Danish memory clinics during 2016‐2020 compared controls 10‐year period. Conditional logistic regression produced rate ratios (IRRs). RESULTS The included 1745 cases...
ABSTRACT Synaptic degeneration has been linked to cognitive decline. The presynaptic protein, synaptosomal‐associated protein 25 kDA (SNAP‐25), is crucial for synaptic transmission and suggested as a biomarker in Alzheimer's disease (AD). In the current study, we investigated ability of SNAP‐25 differentiate between heterogenous dementia etiologies whether could be staging marker AD. cerebrospinal fluid (CSF) from retrospective ( n = 187) prospective 134) cohort was with immunoprecipitation...
The regional cerebral metabolic rate for glucose (rCMRglu) has never been investigated in large consecutive groups of patients with normal pressure hydrocephalus (NPH), a potentially treatable form dementia an unpredictable outcome after shunt surgery. Using PET and 18F-2-fluorodeoxyglucose, rCMRglu was studied 18 who fulfilled hydrodynamic criteria NPH whom biopsy the frontal cortex obtained. When compared age matched group 11 healthy subjects, showed significant reduction all cortical...