A5023506438- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Peripheral Neuropathies and Disorders
- Retinal and Optic Conditions
- HIV/AIDS Research and Interventions
- Systemic Sclerosis and Related Diseases
- HIV-related health complications and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Long-Term Effects of COVID-19
- Tryptophan and brain disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Air Quality and Health Impacts
- Ocular Diseases and Behçet’s Syndrome
- Parkinson's Disease Mechanisms and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Skin and Cellular Biology Research
- Glaucoma and retinal disorders
- Dietary Effects on Health
Johns Hopkins Medicine
2017-2025
Johns Hopkins University
2016-2025
University of Manitoba
2017-2024
The University of Texas Southwestern Medical Center
2022-2024
Karolinska Institutet
2020-2024
United States Department of Veterans Affairs
2024
Max Delbrück Center
2024
Charité - Universitätsmedizin Berlin
2024
James A. Haley Veterans' Hospital
2024
National Institute on Aging
2024
<h3>Importance</h3> Persons with immune dysfunction have a higher risk for severe COVID-19 outcomes. However, these patients were largely excluded from SARS-CoV-2 vaccine clinical trials, creating large evidence gap. <h3>Objective</h3> To identify the incidence rate and ratio (IRR) breakthrough infection after vaccination among persons or without dysfunction. <h3>Design, Setting, Participants</h3> This retrospective cohort study analyzed data National COVID Cohort Collaborative (N3C),...
To assess the association between diet quality and intake of specific foods with disability symptom severity in people multiple sclerosis (MS).In 2015, participants North American Research Committee on MS (NARCOMS) Registry completed a dietary screener questionnaire that estimates fruits, vegetables legumes, whole grains, added sugars, red/processed meats. We constructed an overall score for each individual based these food groups; higher scores denoted healthier diet. assessed status as...
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are cholesterol metabolites that can signal through receptors on cells throughout body, including in CNS and immune system. Whether bile acid metabolism abnormal MS unknown. Using global targeted metabolomic profiling, we identified lower levels circulating multiple cohorts adult pediatric patients with compared controls. In white matter lesions from brain tissue, noted presence glial cells. To...
Sphingosine-1-phosphate receptor (S1P) modulators and anti-CD20 therapies impair humoral responses to SARS-CoV-2 mRNA vaccines. Relatively few studies have assessed the impact of an array disease modifying (DMTs) for multiple sclerosis (MS) on T cell immune vaccination. In 101 people with MS, we measured via immunoassay measure IgG against COVID-19 spike S1 glycoprotein in serum. We also using FluoroSpot assay interferon gamma (IFN-γ) (Mabtech, Sweden) cryopreserved rested PBMCs then...
<h3>Importance</h3> Low serum 25-hydroxyvitamin D (25[OH]D) levels are associated with an increased risk of multiple sclerosis (MS) as well disease activity and rate progression in clinically isolated syndromes early MS. <h3>Objective</h3> To assess the association between 25(OH)D course prognosis patients relapsing-remitting MS treated interferon beta-1b. <h3>Design, Setting, Participants</h3> We conducted a prospective cohort study assessing subsequent characterized by magnetic resonance...
Our objective was to determine if amyotrophic lateral sclerosis (ALS) risk varies according body mass index (BMI) captured up three decades earlier. At baseline 537,968 females and 562,942 males in five ongoing cohorts reported height, current weight at age 18/21 years. During 14–28 years of follow-up, 1153 participants developed ALS. Cohort-specific Cox proportional hazards models were used estimate rates that then pooled with random-effects models. Results showed lower BMI associated ALS;...
Multiple sclerosis is a complex neurological disease, with ∼20% of risk heritability attributable to common genetic variants, including >230 identified by genome-wide association studies. strands evidence suggest that much the remaining also due additive effects variants rather than epistasis between these or mutations exclusive individual families. Here, we show in 68,379 cases and controls up 5% this explained low-frequency variation gene coding sequence. We identify four novel genes...
BACKGROUND. Our goal was to identify changes in the metabolome multiple sclerosis (MS) and how vitamin D supplementation alters metabolic profiles MS patients healthy controls.
To assess whether a high-salt diet, as measured by urinary sodium concentration, is associated with faster conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) and MS activity disability.BENEFIT was randomized clinical trial comparing early versus delayed interferon beta-1b treatment in 465 patients CIS. Each patient provided median of 14 (interquartile range = 13-16) spot urine samples throughout the 5-year follow-up. We estimated 24-hour excretion level at each...
Loss of CDH1 (E-cadherin) expression in cancer cells may promote cell migration and invasion. Therefore, we hypothesised that loss colorectal carcinoma might be associated with aggressive features clinical outcome. Utilising molecular pathological epidemiology database 689 rectal colon cases the Nurses' Health Study Professionals Follow-up Study, assessed tumour by immunohistochemistry. Multivariate logistic regression analysis was conducted to assess association growth pattern...
Background: Comparative studies of characteristics optic neuritis (ON) associated with myelin oligodendrocyte glycoprotein-IgG (MOG-ON) and aquaporin-4-IgG (AQP4-ON) seropositivity are limited. Objective: To compare visual optical coherence tomography (OCT) measures following AQP4-ON, MOG-ON, multiple sclerosis ON (MS-ON). Methods: In this cross-sectional study, 48 16 40 MS-ON, 31 healthy control participants underwent monocular letter-acuity assessment spectral-domain OCT. Eyes a history...
Therapeutic development in progressive multiple sclerosis (PMS) has been hampered by a lack of reliable biomarkers to monitor neurodegeneration. Optical coherence tomography (OCT)-derived retinal measures have proposed as promising fulfill this role. However, it is unclear whether atrophy persists PMS, exceeds normal aging, or can be distinguished from relapsing-remitting (RRMS).178 RRMS, 186 and 66 control participants were followed with serial OCT for median follow-up 3.7 years.The...
Background: People with multiple sclerosis (MS) may be at higher risk for complications from the 2019 coronavirus (COVID-19) pandemic due to use of immunomodulatory disease modifying therapies (DMTs) and greater need medical services. Objectives: To evaluate factors COVID-19 susceptibility describe pandemic’s impact on healthcare delivery. Methods: Surveys sent MS patients Cleveland Clinic, Johns Hopkins, Vall d’Hebron-Centre d’Esclerosi Múltiple de Catalunya in April May 2020 collected...
To assess the effects of demographics, lifestyle factors, and comorbidities on serum neurofilament light chain (sNfL) levels in people without neurologic disease establish demographic-specific reference ranges sNfL.The National Health Nutrition Examination Survey (NHANES) is a representative sample US population which detailed information demographic, lifestyle, routine laboratory tests, overall health status are systematically collected. From stored samples, we measured sNfL using novel...
ObjectiveTo study in cerebrospinal fluid (CSF) of COVID-19 subjects if a "cytokine storm" or neuroinflammation are implicated pathogenesis neurological complications.MethodsCross-sectional CSF neuroinflammatory profiles from 18 with complications categorized by diagnosis (stroke, encephalopathy, headache) and illness severity. was compared healthy, infectious disorders stroke controls (n = 82). Cytokines (IL-6, TNFα, IFNγ, IL-10, IL-12p70, IL-17A), inflammation coagulation markers...
Rituximab is used widely for relapse prevention in neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein (MOG)-IgG-associated disease (MOGAD); however, data regarding the effectiveness safety of long-term rituximab use these conditions are limited. In this study, we sought to evaluate clinical outcomes patients with aquaporin-4 IgG-seropositive (AQP4-IgG+) NMOSD MOGAD treated rituximab.We performed a retrospective chart review AQP4-IgG+ or followed at Johns...
BackgroundIntermittent fasting or calorie restriction (CR) diets provide anti-inflammatory and neuroprotective advantages in models of multiple sclerosis (MS); data humans are sparse.MethodsWe conducted a randomised-controlled feeding study different CR 36 people with MS over 8 weeks. Participants were randomised to 1 3 diets: 1) control diet, which the participant received 100% his her needs 7 days per week, 2) daily 78% 3) an intermittent on 5 week 25% 2 (i.e., "5:2" style diet)....
Background: The multiple sclerosis (MS) community is highly interested in diet as a potential protective factor against disability, but empirical evidence remains limited. Objective: Evaluate associations between patient-reported Mediterranean alignment and objective disability real-world MS cohort. Methods: Data were analyzed from persons with MS, aged 18–65, who completed the Diet Adherence Screener (MEDAS), Functional Composite (MSFC; primary metric), outcomes (PROs; gait disturbance,...