Alfred Anzalone
A5056664137- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Primary Care and Health Outcomes
- COVID-19 diagnosis using AI
- Vitamin C and Antioxidants Research
- Healthcare cost, quality, practices
- Biomedical Text Mining and Ontologies
- COVID-19 and Mental Health
- Intensive Care Unit Cognitive Disorders
- Telemedicine and Telehealth Implementation
- Medical Coding and Health Information
- Global Health Workforce Issues
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Mobile Health and mHealth Applications
- Chronic Disease Management Strategies
- Maternal and fetal healthcare
- Economic and Financial Impacts of Cancer
- Healthcare Systems and Technology
- Heparin-Induced Thrombocytopenia and Thrombosis
- SARS-CoV-2 detection and testing
University of Nebraska Medical Center
2021-2025
Collaborative Research Group
2021-2024
Cohort (United Kingdom)
2021-2024
Northern Great Plains Research Laboratory
2021
<h3>Importance</h3> Persons with immune dysfunction have a higher risk for severe COVID-19 outcomes. However, these patients were largely excluded from SARS-CoV-2 vaccine clinical trials, creating large evidence gap. <h3>Objective</h3> To identify the incidence rate and ratio (IRR) breakthrough infection after vaccination among persons or without dysfunction. <h3>Design, Setting, Participants</h3> This retrospective cohort study analyzed data National COVID Cohort Collaborative (N3C),...
Abstract Objective In response to COVID-19, the informatics community united aggregate as much clinical data possible characterize this new disease and reduce its impact through collaborative analytics. The National COVID Cohort Collaborative (N3C) is now largest publicly available HIPAA limited dataset in US history with over 6.4 million patients a testament partnership of 100 organizations. Materials Methods We developed pipeline for ingesting, harmonizing, centralizing from 56...
Abstract Background Coronavirus Disease 2019 (COVID‐19) has affected every country globally, with hundreds of millions people infected the SARS‐CoV‐2 virus and over 6 million deaths to date. It is unknown how alcohol use disorder (AUD) affects severity mortality COVID‐19. AUD known increase bacterial pneumonia risk developing acute respiratory distress syndrome. Our objective determine whether individuals have increased from Methods We utilized a retrospective cohort study inpatients...
Background. Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality solid organ transplant (SOT) recipients. The National COVID Cohort Collaborative was developed to facilitate analysis of patient-level data for those tested COVID-19 across the United States. Methods. In this study, we identified a cohort SOT recipients testing positive or negative (COVID+ COVID−, respectively) between January 1, 2020, November 20, 2020. Univariable multivariable logistic...
Rural communities are among the most underserved and resource-scarce populations in United States. However, there limited data on COVID-19 outcomes rural America. This study aims to compare hospitalization rates inpatient mortality SARS-CoV-2-infected persons stratified by residential rurality.
The Health Information Technology for Economic and Clinical Act of 2009 introduced the Meaningful Use program to incentivize adoption electronic health records (EHRs) in U.S. This study investigates disparities EHR interoperability between rural urban physicians context federal programs like Medicare Access CHIP Reauthorization 2015 21st Century Cures Act. A cross-sectional analysis was conducted using 2021 Quality Payment Program Experience Report Public File compare Promoting...
During the COVID-19 pandemic, health systems rapidly introduced in-home telehealth to maintain access care. Evidence is evolving regarding telehealth's impact on disparities. Our objective was evaluate associations between socioeconomic factors and rurality with ambulatory care use during pandemic.We conducted a retrospective study at an academic medical centre in midwestern United States. We included established new patients who received one-year period vs pre-COVID-19 baseline cohorts. The...
Abstract Objectives To define pregnancy episodes and estimate gestational age within electronic health record (EHR) data from the National COVID Cohort Collaborative (N3C). Materials Methods We developed a comprehensive approach, named Hierarchy rule-based episode Inference integrated with Pregnancy Progression Signatures (HIPPS), applied it to EHR in N3C (January 1, 2018–April 7, 2022). HIPPS combines: (1) an extension of previously published algorithm, (2) novel algorithm detect...
Abstract Background Real-world evidence of coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) booster effectiveness among patients with immune dysfunction are limited. Methods We included data from in the United States National COVID Cohort Collaborative (N3C) who completed ≥2 doses mRNA vaccination between 10 December 2020 and 27 May 2022. Immune conditions human immunodeficiency virus infection, solid organ or bone marrow transplant, autoimmune diseases, cancer. defined incident...
While older males are at the highest risk for poor coronavirus disease 2019 (COVID-19) outcomes, it is not known if this applies to immunosuppressed recipient of a solid organ transplant (SOT), nor how type allograft transplanted may impact outcomes. In cohort study adult (>18 years) patients testing positive COVID-19 (January 1, 2020-June 21, 2021) from 56 sites across United States identified using National COVID Cohort Collaborative (N3C) Enclave, we used multivariable Cox proportional...
Coronavirus disease 2019 (COVID-19) is now the third leading cause of death in United States. Malnutrition hospitalized patients increases risk complications. However, effect malnutrition on outcomes infected unclear. This study aims to identify impact mortality and adverse hospital events with COVID-19.
Background While COVID-19 vaccines reduce adverse outcomes, post-vaccination SARS-CoV-2 infection remains problematic. We sought to identify community factors impacting risk for breakthrough infections (BTI) among fully vaccinated persons by rurality. Methods conducted a retrospective cohort study of US adults sampled between January 1 and December 20, 2021, from the National COVID Cohort Collaborative (N3C). Using Kaplan-Meier Cox-Proportional Hazards models adjusted demographic differences...
A momentous amount of health data has been and is being collected. Across all levels care, are driving decision-making impacting patient care. new field knowledge role for those in care emerging-the need a data-informed workforce. In this viewpoint, we describe the approaches needed to build workforce, critical skill ecosystem.
To provide a foundational methodology for differentiating comorbidity patterns in subphenotypes through investigation of multi-site dementia patient dataset.
Patients with coronavirus disease 2019 (COVID-19) often experience persistent symptoms, known as postacute sequelae of COVID-19 or long COVID, after severe acute respiratory syndrome 2 (SARS-CoV-2) infection. Chronic lung (CLD) has been identified in small-scale studies a potential risk factor for COVID. This large-scale retrospective cohort study using the National COVID Cohort Collaborative data evaluated link between CLD and over 6 months SARS-CoV-2 We included adults (aged ≥18 years) who...
Posttransplant diabetes mellitus (PTDM) is an important complication for solid organ transplant recipients (SOTRs). COVID-19 has been associated with increased risk of incident in the general population. However, association between and new-onset PTDM not explored.
Importance Understanding whether there are racial and ethnic residential disparities in prenatal telehealth uptake is necessary for ensuring equitable access guiding implementation of future hybrid (ie, both in-person) care. Objective To assess temporal changes individuals using care before during the COVID-19 public health emergency (PHE) by race ethnicity residence location US. Design, Setting, Participants This retrospective cohort study analyzed electronic record data visits from...
Exogenous estrogen is associated with reduced coronavirus disease (COVID) mortality in nonimmunosuppressed/immunocompromised (non-ISC) postmenopausal females. Here, we examined the association of or testosterone hormone replacement therapy (HRT) COVID outcomes solid organ transplant recipients (SOTRs) compared to non-ISC individuals, given known differences sex-based risk these populations. SOTRs ≥45 years old COVID-19 between April 1, 2020 and July 31, 2022 were identified using National...
Abstract Background Anticoagulation (AC) utilization patterns and their predictors among hospitalized coronavirus disease 2019 (COVID-19) patients have not been well described. Methods Using the National COVID Cohort Collaborative, we conducted a retrospective cohort study (2020–2022) to assess AC use identify factors associated with therapeutic employing modified Poisson regression. Results Among 162 842 COVID-19 patients, 64% received 24% AC. Therapeutic declined from 32% in 2020 12% 2022,...
It is unclear whether vitamin D benefits inpatients with COVID-19. Objective: To examine the relationship between and COVID-19 outcomes. Design: Cohort study. Setting: National COVID Collaborative (N3C) database. Patients: 158,835 patients confirmed a sub-cohort severe disease (n = 81,381) hospitalized 1 January 2020 31 July 2021. Methods: We identified prescribing using codes for its derivatives. created defined as having those who required mechanical ventilation or extracorporeal membrane...