A5060599394- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Extracellular vesicles in disease
- Tryptophan and brain disorders
- Immune cells in cancer
- Immune Response and Inflammation
- Peripheral Neuropathies and Disorders
- Neuropeptides and Animal Physiology
- vaccines and immunoinformatics approaches
- Adenosine and Purinergic Signaling
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- Liver Diseases and Immunity
- Diet and metabolism studies
- PARP inhibition in cancer therapy
- Ginseng Biological Effects and Applications
- Acute Ischemic Stroke Management
- Drug Transport and Resistance Mechanisms
- Cytokine Signaling Pathways and Interactions
- Traumatic Brain Injury and Neurovascular Disturbances
- Galectins and Cancer Biology
- Immunotherapy and Immune Responses
Johns Hopkins University
2021-2024
Johns Hopkins Medicine
2021-2024
Johns Hopkins Hospital
2023
University Medical Center Hamburg-Eppendorf
2017-2021
Universität Hamburg
2017-2021
Sphingosine-1-phosphate receptor (S1P) modulators and anti-CD20 therapies impair humoral responses to SARS-CoV-2 mRNA vaccines. Relatively few studies have assessed the impact of an array disease modifying (DMTs) for multiple sclerosis (MS) on T cell immune vaccination. In 101 people with MS, we measured via immunoassay measure IgG against COVID-19 spike S1 glycoprotein in serum. We also using FluoroSpot assay interferon gamma (IFN-γ) (Mabtech, Sweden) cryopreserved rested PBMCs then...
Lymphocytes have dichotomous functions in ischemic stroke. Regulatory T cells are protective, while IL-17A from innate lymphocytes promotes the infarct growth. With recent advances of cell-subtype specific transgenic mouse models it now has become possible to study complex interplay cell subpopulations stroke.In a murine model experimental stroke we analyzed effects IL-10 on functional outcome for up 14 days post-ischemia and defined source brains based immunohistochemistry, flow cytometry,...
ABSTRACT Background Bile acid metabolism is altered in multiple sclerosis (MS) and tauroursodeoxycholic (TUDCA) supplementation ameliorated disease mouse models of MS. Methods Global metabolomics was performed an observational cohort people with MS followed by pathway analysis to examine relationships between baseline metabolite levels subsequent brain retinal atrophy. A double-blind, placebo-controlled trial, completed progressive (PMS), randomized receive either TUDCA (2g daily) or placebo...
Abstract Multiple sclerosis (MS) has traditionally been viewed as a chronic inflammatory disease affecting the white matter of central nervous system. However, over past two decades, increasing evidence highlighted role gray pathology in MS-related disability. Numerous studies have linked presence leptomeningeal inflammation to more severe course, underscoring its potential importance driver MS. The major components include T cells, B macrophages, follicular dendritic and plasma cells. Since...
Abstract Background Sphingosine-1-phosphate receptor (S1P) modulators and antiCD20 therapies impair humoral responses to SARS-CoV-2 mRNA vaccines. Whether disease modifying (DMTs) for multiple sclerosis (MS) also impact T cell immune response vaccination is unknown. Methods In 101 people with MS, we measured via an immunoassay measure IgG against the COVID-19 spike S1 glycoprotein in serum. We using FluoroSpot assay interferon gamma (IFN-γ) (Mabtech,Sweden) cryopreserved rested PBMCs then...
Mammalian ecto-ADP-ribosyltransferases (ecto-ARTs or also ARTCs) catalyze the ADP-ribosylation of cell surface proteins using extracellular nicotinamide adenine dinucleotide (NAD+) as substrate. By this post-translational protein modification, ecto-ARTs modulate function various target proteins. A functional role ARTC2 has been demonstrated for peripheral immune cells such T and macrophages. Yet, little is known about in central nervous system on microglia. Here, we identified ARTC2.1 major...
<title>Abstract</title> Extracellular vesicles (EVs) are released by all cells, can cross the blood-brain barrier, and have been shown to play an important role in cellular communication, substance shuttling, immune modulation. In recent years EVs shifted into focus multiple sclerosis (MS) research as potential plasma biomarkers therapeutic vehicles. Yet little is known about disease-associated changes central nervous system (CNS). To address this gap, we characterized physical proteomic of...
Abstract Extracellular vesicles (EVs) are released by all cells, can cross the blood–brain barrier, and have been shown to play an important role in cellular communication, substance shuttling, immune modulation. In recent years EVs shifted into focus multiple sclerosis (MS) research as potential plasma biomarkers therapeutic vehicles. Yet little is known about disease-associated changes central nervous system (CNS). To address this gap, we characterized physical proteomic of mouse spinal...
Abstract In multiple sclerosis (MS) the circulating metabolome is dysregulated, with indole lactate (ILA) being one of most significantly reduced metabolites. We demonstrate that oral supplementation ILA impacts key MS disease processes in two preclinical models. reduces neuroinflammation by dampening immune cell activation as well infiltration; and promotes remyelination vitro oligodendrocyte differentiation through aryl hydrocarbon receptor (AhR). Supplementation ILA, a reductive...
Abstract Background: Lymphocytes have dichotomous functions in ischemic stroke. Regulatory T cells are protective, while IL-17A from innate lymphocytes promotes the infarcts growth. With recent advances of cell-subtype specific transgenic mouse models it now has become possible to study complex interplay cell subpopulations Methods: In a murine model experimental stroke we analyzed effects IL-10 on functional outcome for up 14 days post-ischemia and defined source brains based...