A5004261784- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Immune cells in cancer
- Immune Response and Inflammation
- Neurological Complications and Syndromes
- Muscle Physiology and Disorders
- Orthopedic Surgery and Rehabilitation
- Nanoplatforms for cancer theranostics
- Acute Ischemic Stroke Management
- Musculoskeletal pain and rehabilitation
- Elbow and Forearm Trauma Treatment
- Neurogenetic and Muscular Disorders Research
- Spine and Intervertebral Disc Pathology
- MicroRNA in disease regulation
- Nuclear Structure and Function
- RNA Research and Splicing
- Shoulder Injury and Treatment
- Myofascial pain diagnosis and treatment
- Biomedical and Chemical Research
- Spinal Hematomas and Complications
- Adipokines, Inflammation, and Metabolic Diseases
Universität Hamburg
2021-2024
University Medical Center Hamburg-Eppendorf
2021-2024
Eppendorf (Belgium)
2021
Abstract SNURPORTIN-1, encoded by SNUPN , plays a central role in the nuclear import of spliceosomal small ribonucleoproteins. However, its physiological function remains unexplored. In this study, we investigate 18 children from 15 unrelated families who present with atypical muscular dystrophy and neurological defects. Nine hypomorphic biallelic variants, predominantly clustered last coding exon, are ascertained to segregate disease. We demonstrate that mutant SPN1 failed oligomerize...
Lymphocytes have dichotomous functions in ischemic stroke. Regulatory T cells are protective, while IL-17A from innate lymphocytes promotes the infarct growth. With recent advances of cell-subtype specific transgenic mouse models it now has become possible to study complex interplay cell subpopulations stroke.In a murine model experimental stroke we analyzed effects IL-10 on functional outcome for up 14 days post-ischemia and defined source brains based immunohistochemistry, flow cytometry,...
Abstract As a prototypical proinflammatory cytokine, interleukin-1 (IL-1) exacerbates the early post-stroke inflammation, whereas its neutralization is protective. To further investigate underlying cell-type-specific IL-1 effects, we subjected (α/β) knockout ( Il1 −/− ) and wildtype (WT) littermate mice to permanent middle cerebral artery occlusion (pMCAO) assessed immune cell infiltration cytokine production in ischemic hemisphere by flow cytometry 24 h 72 after stroke. showed smaller...
Multiple consensus statements have called for preclinical randomized controlled trials to improve translation in stroke research. We investigated the efficacy of an interleukin-17A neutralizing antibody a multi-centre trial using murine ischaemia reperfusion model. Twelve-week-old male C57BL/6 mice were subjected 45 min transient middle cerebral artery occlusion four centres. Mice randomly assigned (1:1) receive either anti-interleukin-17A (500 µg) or isotype intravenously 1 h after...
Extracellular ATP released to the ischemic brain parenchyma is quickly metabolized by ectonucleotidases. Among them, ecto-5'-nucleotidase CD73 encoded Nt5e generates immunosuppressive adenosine. Genetic deletion of led increased infarct size in murine photothrombotic stroke model. We aimed at validating this result using transient middle cerebral artery occlusion (tMCAO) model that represents pathophysiological aspects penumbra and reperfusion. Three days after tMACO, we did not detect a...
Supracondylar humerus fractures (SCHFs) are the most common elbow in children. Traumatic median nerve injury and isolated lesions of its pure forearm motor branch, anterior interosseus (AIN), have both been independently reported as complications displaced SCHFs. Our main objectives were to characterize neurological syndrome distinguish from AIN determine prognosis after
Extracellular ATP released to the ischemic brain parenchyma is quickly metabolized by ectonucleotidases. Among them, ecto-5’-nucleotidase CD73 encoded Nt5e mediates generation of immunosuppressive adenosine, constituting a potential therapeutic target stop inflammatory cascade. Genetic deletion led increased infarct size in murine photothrombotic stroke model. Therefore we aimed at validating proposed protective function CD73-derived adenosine using intraluminal filament model for transient...