A5067946693- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Viral gastroenteritis research and epidemiology
- Digital Imaging for Blood Diseases
- Animal Virus Infections Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cell Image Analysis Techniques
- SARS-CoV-2 and COVID-19 Research
- Muscle Physiology and Disorders
- Gastric Cancer Management and Outcomes
- Endometriosis Research and Treatment
- Medical Image Segmentation Techniques
- RNA Research and Splicing
- Wound Healing and Treatments
- Gynecological conditions and treatments
- Essential Oils and Antimicrobial Activity
- Medical Imaging and Analysis
- Colorectal Cancer Surgical Treatments
- Urologic and reproductive health conditions
- Anatomy and Medical Technology
- Research on Leishmaniasis Studies
- Nuclear Structure and Function
- Reproductive System and Pregnancy
- Colorectal and Anal Carcinomas
Kent Hastanesi
2022-2025
Acıbadem Adana Hospital
2021-2025
Acıbadem University
2020-2024
İstanbul Nişantaşı Üniversitesi
2023
Abstract The tubule index is a vital prognostic measure in breast cancer tumor grading and visually evaluated by pathologists. In this paper, computer-aided patch-based deep learning segmentation framework, named Tubule-U-Net, developed proposed to segment tubules Whole Slide Images (WSI) of cancer. Moreover, paper presents new dataset consisting 30820 polygonal annotated 8225 patches. Tubule-U-Net framework first uses patch enhancement technique such as reflection or mirror padding then...
Abstract SNURPORTIN-1, encoded by SNUPN , plays a central role in the nuclear import of spliceosomal small ribonucleoproteins. However, its physiological function remains unexplored. In this study, we investigate 18 children from 15 unrelated families who present with atypical muscular dystrophy and neurological defects. Nine hypomorphic biallelic variants, predominantly clustered last coding exon, are ascertained to segregate disease. We demonstrate that mutant SPN1 failed oligomerize...
Abstract Mitosis assessment of breast cancer has a strong prognostic importance and is visually evaluated by pathologists. The inter, intra-observer variability this high. In paper, two-stage deep learning approach, named MITNET, been applied to automatically detect nucleus classify mitoses in whole slide images (WSI) cancer. Moreover, paper introduces two new datasets. first dataset used the WSIs, which contains 139,124 annotated nuclei 1749 patches extracted from 115 WSIs tissue, second...
Background Emerging evidence suggests multiparametric prostate MRI's role in evaluating cancer (PCa) aggressiveness. Purpose To evaluate the utility of quantitative sequences MRI for assessing peripheral zone PCa aggressiveness, focusing on added value relaxation maps to ADC. Material and Methods In total, 64 men undergoing preoperative bi-parametric with synthetic were retrospectively enrolled. Radiologists delineated lesions ADC MRI, matched digitized whole-mount specimens. was graded as...
Abstract The SARS-CoV-2 virus caused the most severe pandemic around world, and vaccine development for urgent use became a crucial issue. Inactivated formulated vaccines such as Hepatitis A smallpox proved to be reliable approaches immunization prolonged periods. In this study, gamma-irradiated inactivated does not require an extra purification process, unlike chemically vaccines. Hence, novelty of our candidate (OZG-38.61.3) is that it non-adjuvant added, gamma-irradiated, intradermally...
Relapsed and refractory CD19-positive B-cell acute lymphoblastic leukemia (ALL) non-Hodgkin lymphoma (NHL) are the focus of studies on hematological cancers. Treatment these malignancies has undergone recent transformation with development new gene therapy molecular biology techniques, which safer well-tolerated therapeutic approaches. The CD19 antigen is most studied target in This study reports results clinical-grade production, quality control, vivo efficacy processes ISIKOK-19 cells as...
In women with unexplained infertility (UI) and recurrent in vitro fertilization (IVF) failures, the etiology is often unclear. Endometrial immune perturbations use of markers associated these dysregulations are great interest diagnosis treatment UI. However, reliable biomarkers standardized quantification methods lacking. Here, to address endometrial dysregulation UI patients IVF we performed tissue sampling immunostaining CD56 (uNK), CD138, BCL-6. Of cases, 57.9% had positive stroma, while...
Abstract The SARS-CoV-2 virus caused the most severe pandemic around world, and vaccine development for urgent use became a crucial issue. Inactivated formulated vaccines such as Hepatitis A, oral polio vaccine, smallpox proved to be reliable approaches immunization prolonged periods. During pandemic, we produced an inactivated candidate, having advantages of being manufactured rapidly tested easily in comparison with recombinant vaccines. In this study, that includes gamma irradiation...
The number of breast cancer cases and mortality rate has been on the rise globally. For effective treatment curbing rate, early diagnosis is paramount. To evaluate effectiveness treatment, a fundamental step histopathological examination state nuclei. However this challenging task for various reasons. Accordingly, we perform nuclei detection in histopathology images using RetinaNet with ResNet-152 as feature extractor. data used training validation model was carefully collected at our...
The OSNA technique is based on reverse transcription loop-mediated DNA amplification for the detection of cytokeratin 19 (CK19) messen-ger RNA (mRNA). purpose our paper, which represents first study in literature, to test accuracy this method lymph node metastases patients undergoing robotic radical prostatectomy with dis-section.Our cohort consisted that have undergone extended dissec-tion. Lymph nodes were evaluated imprint and then frozen section examination. remaining tissue was by method....
Breast cancer, being the second most frequently seen cancer globally, is common among women. Early and accurate diagnosis dependent on correct identification of nuclei in histopathological images, which a very tedious task when it done manually. The proposed method deep learning model using U-Net architecture supplied with various pre- post-processing techniques. was trained tested unique dataset. Our performed segmentation Dice score 0.84, true negative rate (TNR) 0.95, positive (TPR) an...
Objective: St. John’s wort (SJW) oil (Hypericum perforatum) has been used for its immunomodulatory and anti-inflammatory effects. Several studies have shown the efficacy of SJW on wound healing. The aim this study is to assess effectiveness using a combination biochemical, histopathological laser Doppler evaluations. Materials Methods: Sixteen young Wistar albino rats were as case control groups (having 8 in each group). After anesthesia protocol, 6 mm punch biopsy was taken from six...
e13607 Background: The Nottingham histologic grade (NHG) is a strong prognostic factor in early-stage breast cancer. It consists of nuclear pleomorphism, tubular formation, and mitotic count. We recently developed an artificial intelligence (AI) based automatic grading system. Methods: In this study, we have retrospectively evaluated 179,651 hematoxylin eosin-stained patches extracted from 402 digitized biopsies 338 patients with confirmed invasive ductal carcinoma diagnosis. data was...
Extramural venous invasion is an independent predictor of poor outcome in colorectal cancer, whereas the significance intramural component and lymphatic perineural unclear.To evaluate prognostic impact components for venous, lymphatic, invasions relation these patterns with clinicopathological features patients colon cancer.A retrospective cross-sectional study.The analysis included 626 cancer stages II III. All were divided into four categories (no invasion, only, extramural or both...
Characterisation of the Leishmania donovani/L.infantum Hybrid Isolated from an Autochothonous Kala-Azar Patient: Preliminary Results In Vivo Model Amaç: Bu çalışmada, Manisa'da tedavi gören bir viseral leishmaniasis hastasından izole edilen ve Leishmania'lara özgü ITS-1, hsp70 cpb gen bölgelerine yönelik analizlerle hibridi olduğu gösterilen etkenin karakterizasyonuna in vivo deneyler sunulmakta olup, ilk sonuçlar L