A5004430282- Circadian rhythm and melatonin
- Helicobacter pylori-related gastroenterology studies
- Stress Responses and Cortisol
- Organ Transplantation Techniques and Outcomes
- Biochemical Analysis and Sensing Techniques
- SARS-CoV-2 and COVID-19 Research
- Neuroendocrine regulation and behavior
- Immune Response and Inflammation
- Burn Injury Management and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Vitamin C and Antioxidants Research
- Sperm and Testicular Function
- Effects of Radiation Exposure
- Pancreatitis Pathology and Treatment
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Biochemical effects in animals
- Electrospun Nanofibers in Biomedical Applications
- Probiotics and Fermented Foods
- Fatty Acid Research and Health
- Drug-Induced Hepatotoxicity and Protection
- Orthopedic Surgery and Rehabilitation
- Wound Healing and Treatments
Kent Hastanesi
2019-2025
Acıbadem Adana Hospital
2019-2025
Acıbadem University
2009-2022
Marmara University
2003-2019
Maltepe University
2019
Trakya University
2017
Istanbul Medeniyet University
2017
Kasımpaşa Asker Hastanesi
2006
Turkish Society of Hematology
2005
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
1999-2004
(1) Background: The aim of the present study was to evaluate gastroprotective potential ferulic acid (FA) on indomethacin-induced gastric ulcers in rats with macroscopic and microscopic examinations along biochemical assays. (2) Methods: After 24 h starvation, ulcer induced male Sprague-Dawley by subcutaneous indomethacin (25 mg/kg) injection. Fifteen minutes after induction, were treated either tween 80 or FA. FA given oral gavage at 100 mg/kg, 250 500 mg/kg. In fourth hour, euthanized...
Abstract Background Inflammatory bowel diseases (IBD) are chronic that not fully understood. Drugs in use can only be applied for a short time due to their side effects. Therefore, research is needed develop new treatment approaches. In addition, it has been proven IBD causes degeneration the enteric nervous system (ENS). recent years, discussed probiotics may have positive effects prevention and of inflammatory degeneration. Akkermansia muciniphila ( A. ) an anaerobic bacterium found mucin...
Acute renal failure is a major complication of gentamicin (GEN), which widely used in the treatment gram-negative infections. A large body vitro and vivo evidence indicates that reactive oxygen metabolites (or free radicals) are important mediators nephrotoxicity. In this study we investigated role radicals gentamicin-induced nephrotoxicity whether melatonin, potent antioxidant could prevent it. For purpose female Sprague-Dawley rats were given intraperitoneally either sulphate (40 mg/kg),...
Oxygen free radicals are considered to be important components involved in the pathophysiological tissue alterations observed during ischemia-reperfusion (I/R). In this study, we investigated putative protective effects of melatonin treatment on renal I/R injury. Wistar albino rats were unilaterally nephrectomized and subjected 45 min pedicle occlusion followed by 1, 3, 6, 24, 48 hr or 1 wk reperfusion. Melatonin (10 mg/kg, s.c.) vehicle was administered twice, 15 prior ischemia immediately...
The anti-tumour drug methotrexate (MTX) induces intestinal mucosa injury resulting in malabsorption and diarrhoea. purpose of this study was to investigate whether exogenous melatonin could protect the gut from MTX-induced damage rats. A single dose MTX (20 mg kg(-1), i.p.) followed by i.p. saline or injections (10 + Mel) for next 5 days. On fifth day, transit assessed using charcoal propagation. Rats were decapitated small segments fixed light (LM) scanning electron microscope (SEM)...
Antimicrobial peptides (AMPs) are a diverse group of small, naturally occurring molecules that orchestrate the innate immune response various organisms, from microorganisms to humans. Characterized by their broad-spectrum activity against bacteria, fungi and viruses, AMPs increasingly recognized for potential as novel therapeutic agents in face rising antibiotic resistance. Here, we present several newly designed AMPs, one which, DTN6, exerts significant organisms with MIC values low 0.5...
Abstract— Regarding the mechanisms of cisplatin (CP) nephrotoxicity, several hypotheses have been put forward, among which oxidative stress (including depletion glutathione and production lipid peroxide) is noticeable. This investigation elucidates role antioxidant system in CP‐induced nephrotoxicity nephroprotection by melatonin. Balb/c mice were injected i.p. with: 1) vehicle control; 2) a single dose 6.5 mg/kg cisplatin, CP group; 3) melatonin 10 for 5 days after injection, CP‐M 4) (10...
the aim of this study was to investigate effects apocynin (APO) on hormone levels, blood-testis barrier, and oxidative biomarkers in monosodium glutamate (MSG) induced testicular degeneration.Sprague Dawley male rats (150-200 g; n = 32) were randomly distributed into four groups: control, APO, MSG, MSG + APO. APO groups administered (120 mg/kg) for 28 days. Moreover, received (25 during last five days experiment. All administrations via oral gavage. Finally, biochemical analyses performed...
The novel coronavirus pneumonia, which was named later as disease 2019 (COVID-19), is caused by the severe acute respiratory syndrome 2, namely SARS-CoV-2. It a positive-strand RNA virus that seventh known to infect humans. COVID-19 outbreak presents enormous challenges for global health behind pandemic outbreak. first diagnosed patient in Turkey has been reported Republic of Ministry Health on March 11, 2020. In May, over 150,000 cases Turkey, and 5.5 million around world have declared. Due...
Monosodium glutamate (MSG) is found in refined foods. Apocynin (APO) a selective NADPH oxidase (NOX) inhibitor. The aim of this experimental study was to investigate possible effects MSG and the curative APO rats. Twenty-eight male Sprague-Dawley rats were randomly divided into four groups (Normal control, APO, + n:7 for each group). received 120 mg/kg solution orally 28 consecutive days. 25 5 days until end experiment. At experiment, all sacrificed liver tissue blood samples taken...
The aim of this study was to investigate the possible protective effects aqueous garlic extract (AGE) against naphthalene-induced oxidative changes in liver, kidney, lung and brain mice. Balb/c mice (25-30 g) either sex were divided into five groups each comprising 10 animals. Mice received for 30 days: 0.9% NaCl, i.p. (control); corn oil, i.p; AGE a dose 125 mg kg-1, i.p.; naphthalene 100 (dissolved oil); (in i.p.) plus i.p.). After decapitation, tissues excised. Malondialdehyde (MDA)...
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic gastrointestinal disorders associated with significant morbidity complications. This study investigates the therapeutic potential of docosahexaenoic acid (DHA) in a trinitrobenzene sulfonic (TNBS) induced model, focusing on inflammation, oxidative stress, intestinal membrane permeability.
It is known that diabetic neuropathy the result of endoneurial edema caused by various biochemical reactions triggered hyperglycemia. This sequence events can cause cessation circulation at perineurial level, or tough layer, which not resilient enough to spread intraneural pressure. Internal and external limiting structures create a double crush phenomenon nerve structure. Decompression trunk separate levels one adjuncts overall treatment plan for neuropathy. In this study, right sciatic...
Abstract: Although the role of oxidative stress in acute pancreatitis (AP) has been studied several animal models, little data are available regarding AP induced by pancreatic duct obstruction. We characterized protective effects melatonin on pancreaticobiliary inflammation and associated remote organ injury. In Sprague–Dawley rats, either common (PBDL; n = 28) or bile (BDL; was ligated a sham operation applied (n 14). Either (10 mg/kg) vehicle (saline; 1 mL/kg) administered...
The objective of this study was to examine the potential radioprotective properties pharmacological doses melatonin on corpus cavernosum and bladder tissues whole-body irradiated (IR) rats. A total 32 male Sprague-Dawley rats were exposed irradiation performed with a LINAC which produced 6 MV photons at focus 100 cm distant from skin. Under ketamine anesthesia, each rat received single dose 800 cGy. Immediately before after IR, treated either saline or (20 10 mg/kg, i.p.) decapitated 12 hr...