A5017459739- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Advancements in Semiconductor Devices and Circuit Design
- Immune responses and vaccinations
- Cytomegalovirus and herpesvirus research
- Biomedical and Engineering Education
- Virus-based gene therapy research
- S100 Proteins and Annexins
- Cancer-related gene regulation
- Hemophilia Treatment and Research
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
Acıbadem Adana Hospital
2021-2023
Acıbadem University
2020-2022
Dornase alfa, the recombinant form of human DNase I enzyme, breaks down neutrophil extracellular traps (NET) that include a vast amount DNA fragments, histones, microbicidal proteins and oxidant enzymes released from necrotic neutrophils in highly viscous mucus cystic fibrosis patients. alfa has been used for decades patients with to reduce viscoelasticity respiratory tract secretions, decrease severity infections, improve lung function. Previous studies have linked abnormal NET formations...
The novel coronavirus pneumonia, which was named later as disease 2019 (COVID-19), is caused by the severe acute respiratory syndrome 2, namely SARS-CoV-2. It a positive-strand RNA virus that seventh known to infect humans. COVID-19 outbreak presents enormous challenges for global health behind pandemic outbreak. first diagnosed patient in Turkey has been reported Republic of Ministry Health on March 11, 2020. In May, over 150,000 cases Turkey, and 5.5 million around world have declared. Due...
Abstract COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, vaccines have become crucial reducing morbidity and mortality. In study, in vitro vivo safety efficacy analyzes of lyophilized candidates inactivated gamma-irradiation were performed. The candidate study OZG-3861 version 1 (V1), virus vaccine, SK-01 a GM-CSF adjuvant added vaccine. applied intradermally to BALB/c mice assess toxicity...
Abstract The SARS-CoV-2 virus caused the most severe pandemic around world, and vaccine development for urgent use became a crucial issue. Inactivated formulated vaccines such as Hepatitis A smallpox proved to be reliable approaches immunization prolonged periods. In this study, gamma-irradiated inactivated does not require an extra purification process, unlike chemically vaccines. Hence, novelty of our candidate (OZG-38.61.3) is that it non-adjuvant added, gamma-irradiated, intradermally...
Relapsed and refractory CD19-positive B-cell acute lymphoblastic leukemia (ALL) non-Hodgkin lymphoma (NHL) are the focus of studies on hematological cancers. Treatment these malignancies has undergone recent transformation with development new gene therapy molecular biology techniques, which safer well-tolerated therapeutic approaches. The CD19 antigen is most studied target in This study reports results clinical-grade production, quality control, vivo efficacy processes ISIKOK-19 cells as...
Chimeric antigen receptor T (CAR-T) cell therapies have already made an impact on the treatment of B-cell malignancies. Although CAR-T are promising, there concerns about commercial products regarding their affordability and sustainability. In this preliminary study, results first production clinical data academic (ISIKOK-19) trial in Turkey presented.A pilot (NCT04206943) designed to assess safety feasibility ISIKOK-19 T-cell therapy for patients with relapsed refractory CD19+ tumors was...
Abstract The novel coronavirus pneumonia, which was named later as Coronavirus Disease 2019 (COVID-19), is caused by the Severe Acute Respiratory Syndrome 2, namely SARS-CoV-2. It a positive-strand RNA virus that seventh known to infect humans. COVID-19 outbreak presents enormous challenges for global health behind pandemic outbreak. first diagnosed patient in Turkey has been reported Republic of Ministry Health on March 11, 2020. Today, over ninety thousand cases Turkey, and two million...
Hemophilia A is an X-linked recessive bleeding disorder caused by a deficiency of plasma coagulation factor VIII (FVIII), and it accounts for about 80%-85% all cases hemophilia. Plasma-derived therapies or recombinant FVIII concentrates are used to prevent treat the symptoms along with FVIII-mimicking antibodies. Recently, European Medicines Agency granted conditional marketing approval first gene therapy hemophilia A. The aim this study was determine effectiveness in correcting...
Abstract COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, vaccines have become crucial reducing morbidity and mortality. In study, in vitro vivo safety efficacy analyzes of lyophilized candidates inactivated gamma-irradiation were performed. The candidate study OZG-3861 version 1 (V1), virus vaccine, SK-01 a GM-CSF adjuvant added vaccine. applied intradermally to BALB/c mice assess toxicity...
Abstract The SARS-CoV-2 virus caused the most severe pandemic around world, and vaccine development for urgent use became a crucial issue. Inactivated formulated vaccines such as Hepatitis A, oral polio vaccine, smallpox proved to be reliable approaches immunization prolonged periods. During pandemic, we produced an inactivated candidate, having advantages of being manufactured rapidly tested easily in comparison with recombinant vaccines. In this study, that includes gamma irradiation...
<sec> <title>UNSTRUCTURED</title> Dornase alfa, the recombinant form of human DNase I enzyme, breaks down neutrophil extracellular traps (NET) that include a vast amount DNA fragments, histones, microbicidal proteins and oxidant enzymes released from necrotic neutrophils in highly viscous mucus cystic fibrosis patients. alfa has been used for decades patients with to reduce viscoelasticity respiratory tract secretions, decrease severity infections, improve lung function. Previous studies...
Abstract BACKGROUNDThe efficacy of SARS-CoV2 single donor convalescent plasma (CP) varied according to the application time and amount antibody that is administered. Single CP has some drawbacks; such as insufficient levels neutralizing activities, requirements blood group compatibility, risk infection transmission. In this study, safety pathogen inactivated, isohemagglutinin-depleted (concentrated) pooled product was investigated. MATERIALS AND METHODSA total sixteen patients were treated...
Abstract BACKGROUND The efficacy of SARS-CoV2 single donor convalescent plasma (CP) varied according to the application time and amount antibody that is administered. Single CP has some drawbacks; such as insufficient levels neutralizing activities, requirements blood group compatibility, risk infection transmission. In this study, safety pathogen inactivated, isohemagglutinin-depleted (concentrated) pooled product was investigated. METHODS A total sixteen patients were treated with either...
Abstract BACKGROUND The efficacy of SARS-CoV2 single donor convalescent plasma (CP) varied according to the application time and amount antibody that is administered. Single CP has some drawbacks; such as insufficient levels neutralizing activities, requirements blood group compatibility, risk infection transmission. In this study, safety pathogen inactivated, isohemagglutinin-depleted (concentrated) pooled product was investigated. METHODS A total sixteen patients were treated with either...
Topic: 25. Gene therapy, cellular immunotherapy and vaccination - Clinical Background: Although hematopoietic stem cell transplantation (HSCT) is a curative treatment for variety of diseases, refractory viral infections post-HSCT are rare, life-threatening conditions due to the deficient T-cell response lacking effective options. Aims: We present data 16 patients who were treated in 3 different centers between 2018-2022 received same VST product various (CMV, EBV, BKV) after HSCT. Methods:...
<sec> <title>UNSTRUCTURED</title> Dornase alfa, the recombinant form of human DNase I enzyme, breaks down neutrophil extracellular traps (NET) that include a vast amount DNA fragments, histones, microbicidal proteins and oxidant enzymes released from necrotic neutrophils in highly viscous mucus cystic fibrosis patients. alfa has been used for decades patients with to reduce viscoelasticity respiratory tract secretions, decrease severity infections, improve lung function. Previous studies...
Abstract Objective Chimeric antigen receptor T (CAR-T) cell therapies already made an impact on the treatment of B malignancies. Although CAR-T are promising, there concerns with commercial products regarding their affordability and sustainability. In this preliminary study, results first productional clinical data academic (ISIKOK-19) from Turkey presented. Materials Methods A pilot trial ( NCT04206943 ) designed to assess safety feasibility ISIKOK-19 T-cell therapy in patients relapsed...
Abstract Introduction The efficacy of SARS-CoV2 standard single donor convalescent plasma varied according to the application time and most importantly amount antibody that is administered. Single has some drawbacks; such as insufficient levels neutralizing activities, requirements blood group compatibility, risk infection transmission. In this study, safety pathogen inactivated, isohemagglutinin-depleted (concentrated) pooled was investigated. Methods ACB-IP 1.0 product prepared follows;...