A5086344494- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- S100 Proteins and Annexins
- Hemophilia Treatment and Research
- COVID-19 Impact on Reproduction
- Biomedical and Engineering Education
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Advancements in Semiconductor Devices and Circuit Design
- Cancer-related gene regulation
- Ocular Disorders and Treatments
Acıbadem University
2020-2023
Acıbadem Adana Hospital
2020-2023
Dornase alfa, the recombinant form of human DNase I enzyme, breaks down neutrophil extracellular traps (NET) that include a vast amount DNA fragments, histones, microbicidal proteins and oxidant enzymes released from necrotic neutrophils in highly viscous mucus cystic fibrosis patients. alfa has been used for decades patients with to reduce viscoelasticity respiratory tract secretions, decrease severity infections, improve lung function. Previous studies have linked abnormal NET formations...
Abstract COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, vaccines have become crucial reducing morbidity and mortality. In study, in vitro vivo safety efficacy analyzes of lyophilized candidates inactivated gamma-irradiation were performed. The candidate study OZG-3861 version 1 (V1), virus vaccine, SK-01 a GM-CSF adjuvant added vaccine. applied intradermally to BALB/c mice assess toxicity...
Abstract The SARS-CoV-2 virus caused the most severe pandemic around world, and vaccine development for urgent use became a crucial issue. Inactivated formulated vaccines such as Hepatitis A smallpox proved to be reliable approaches immunization prolonged periods. In this study, gamma-irradiated inactivated does not require an extra purification process, unlike chemically vaccines. Hence, novelty of our candidate (OZG-38.61.3) is that it non-adjuvant added, gamma-irradiated, intradermally...
Abstract Purpose This prospective clinical case series aimed to evaluate the effect of suprachoroidal implantation mesenchymal stem cells (MSCs) in form spheroids as a cell therapy for retinitis pigmentosa (RP) patients with relatively good visual acuity. Methods Fifteen eyes 15 RP who received MSCs were included. Best-corrected acuity (BCVA), 10–2 and 30–2 field examination multifocal electroretinography (mfERG) recordings recorded at baseline, postoperative 1st, 3rd 6th months during...
Relapsed and refractory CD19-positive B-cell acute lymphoblastic leukemia (ALL) non-Hodgkin lymphoma (NHL) are the focus of studies on hematological cancers. Treatment these malignancies has undergone recent transformation with development new gene therapy molecular biology techniques, which safer well-tolerated therapeutic approaches. The CD19 antigen is most studied target in This study reports results clinical-grade production, quality control, vivo efficacy processes ISIKOK-19 cells as...
Chimeric antigen receptor T (CAR-T) cell therapies have already made an impact on the treatment of B-cell malignancies. Although CAR-T are promising, there concerns about commercial products regarding their affordability and sustainability. In this preliminary study, results first production clinical data academic (ISIKOK-19) trial in Turkey presented.A pilot (NCT04206943) designed to assess safety feasibility ISIKOK-19 T-cell therapy for patients with relapsed refractory CD19+ tumors was...
Hemophilia A is an X-linked recessive bleeding disorder caused by a deficiency of plasma coagulation factor VIII (FVIII), and it accounts for about 80%-85% all cases hemophilia. Plasma-derived therapies or recombinant FVIII concentrates are used to prevent treat the symptoms along with FVIII-mimicking antibodies. Recently, European Medicines Agency granted conditional marketing approval first gene therapy hemophilia A. The aim this study was determine effectiveness in correcting...
Abstract COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, vaccines have become crucial reducing morbidity and mortality. In study, in vitro vivo safety efficacy analyzes of lyophilized candidates inactivated gamma-irradiation were performed. The candidate study OZG-3861 version 1 (V1), virus vaccine, SK-01 a GM-CSF adjuvant added vaccine. applied intradermally to BALB/c mice assess toxicity...
Abstract The SARS-CoV-2 virus caused the most severe pandemic around world, and vaccine development for urgent use became a crucial issue. Inactivated formulated vaccines such as Hepatitis A, oral polio vaccine, smallpox proved to be reliable approaches immunization prolonged periods. During pandemic, we produced an inactivated candidate, having advantages of being manufactured rapidly tested easily in comparison with recombinant vaccines. In this study, that includes gamma irradiation...
<sec> <title>UNSTRUCTURED</title> Dornase alfa, the recombinant form of human DNase I enzyme, breaks down neutrophil extracellular traps (NET) that include a vast amount DNA fragments, histones, microbicidal proteins and oxidant enzymes released from necrotic neutrophils in highly viscous mucus cystic fibrosis patients. alfa has been used for decades patients with to reduce viscoelasticity respiratory tract secretions, decrease severity infections, improve lung function. Previous studies...
Abstract BACKGROUNDThe efficacy of SARS-CoV2 single donor convalescent plasma (CP) varied according to the application time and amount antibody that is administered. Single CP has some drawbacks; such as insufficient levels neutralizing activities, requirements blood group compatibility, risk infection transmission. In this study, safety pathogen inactivated, isohemagglutinin-depleted (concentrated) pooled product was investigated. MATERIALS AND METHODSA total sixteen patients were treated...
Abstract BACKGROUND The efficacy of SARS-CoV2 single donor convalescent plasma (CP) varied according to the application time and amount antibody that is administered. Single CP has some drawbacks; such as insufficient levels neutralizing activities, requirements blood group compatibility, risk infection transmission. In this study, safety pathogen inactivated, isohemagglutinin-depleted (concentrated) pooled product was investigated. METHODS A total sixteen patients were treated with either...
Abstract BACKGROUND The efficacy of SARS-CoV2 single donor convalescent plasma (CP) varied according to the application time and amount antibody that is administered. Single CP has some drawbacks; such as insufficient levels neutralizing activities, requirements blood group compatibility, risk infection transmission. In this study, safety pathogen inactivated, isohemagglutinin-depleted (concentrated) pooled product was investigated. METHODS A total sixteen patients were treated with either...
<sec> <title>UNSTRUCTURED</title> The novel coronavirus disease 2019 (COVID-19) continues to spread over the world and there is still no specific treatment. Beside many drug studies, not enough data about place of cellular therapies. In this study, we used second passage cGMP grade umbilical cord-derived Mesenchymal Stromal Cell (MSC) via a combined intratracheal/intravenous route as administration protocol. After treatment, values inflammatory biomarker C-reactive protein all patients...
<sec> <title>UNSTRUCTURED</title> Dornase alfa, the recombinant form of human DNase I enzyme, breaks down neutrophil extracellular traps (NET) that include a vast amount DNA fragments, histones, microbicidal proteins and oxidant enzymes released from necrotic neutrophils in highly viscous mucus cystic fibrosis patients. alfa has been used for decades patients with to reduce viscoelasticity respiratory tract secretions, decrease severity infections, improve lung function. Previous studies...
Abstract Objective Chimeric antigen receptor T (CAR-T) cell therapies already made an impact on the treatment of B malignancies. Although CAR-T are promising, there concerns with commercial products regarding their affordability and sustainability. In this preliminary study, results first productional clinical data academic (ISIKOK-19) from Turkey presented. Materials Methods A pilot trial ( NCT04206943 ) designed to assess safety feasibility ISIKOK-19 T-cell therapy in patients relapsed...
Abstract Introduction The efficacy of SARS-CoV2 standard single donor convalescent plasma varied according to the application time and most importantly amount antibody that is administered. Single has some drawbacks; such as insufficient levels neutralizing activities, requirements blood group compatibility, risk infection transmission. In this study, safety pathogen inactivated, isohemagglutinin-depleted (concentrated) pooled was investigated. Methods ACB-IP 1.0 product prepared follows;...