A5035109091- Tendon Structure and Treatment
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Circadian rhythm and melatonin
- Orthopedic Surgery and Rehabilitation
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Hair Growth and Disorders
- Shoulder Injury and Treatment
- Wound Healing and Treatments
- Adipose Tissue and Metabolism
- Alzheimer's disease research and treatments
- Myofascial pain diagnosis and treatment
- Bee Products Chemical Analysis
- Body Contouring and Surgery
- Gynecological conditions and treatments
- Hernia repair and management
- Sports injuries and prevention
- Ovarian function and disorders
- Muscle Physiology and Disorders
- Tissue Engineering and Regenerative Medicine
- Cholinesterase and Neurodegenerative Diseases
- Intestinal and Peritoneal Adhesions
Acıbadem Adana Hospital
2019-2025
Kent Hastanesi
2019-2025
Acıbadem University
2016-2024
Ondokuz Mayıs University
2012
Purpose: Human amniotic fluid stem cells (hAFSCs) have shown significant regenerative potential in treating hair loss, wound healing, and tissue repair. This study aims to evaluate the effects of human (hAF) on follicle (HF) regeneration immune system modulation.
Momordica charantia (MC; bitter gourd) is a traditional herbal commonly used for its antidiabetic, antioxidant, contraceptive and antibacterial properties. In the current study, authors aim to observe topical effect of MC cream on wound-healing process in rabbits. Moreover, they compare healing potential with conventional creams therapeutically. Towards this aim, 28 New Zealand rabbits were divided into four groups excision wounds (7 cm²) made their backs. Open wound dressing was carried out...
Abstract COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, vaccines have become crucial reducing morbidity and mortality. In study, in vitro vivo safety efficacy analyzes of lyophilized candidates inactivated gamma-irradiation were performed. The candidate study OZG-3861 version 1 (V1), virus vaccine, SK-01 a GM-CSF adjuvant added vaccine. applied intradermally to BALB/c mice assess toxicity...
Abstract The SARS-CoV-2 virus caused the most severe pandemic around world, and vaccine development for urgent use became a crucial issue. Inactivated formulated vaccines such as Hepatitis A smallpox proved to be reliable approaches immunization prolonged periods. In this study, gamma-irradiated inactivated does not require an extra purification process, unlike chemically vaccines. Hence, novelty of our candidate (OZG-38.61.3) is that it non-adjuvant added, gamma-irradiated, intradermally...
Obesity has become a major global health concern, and its incidence increased sharply in recent years. It been shown that obesity or metabolic syndrome is strong and independent risk factor for cardiovascular disease causes mortality the development of micro albuminuria end-stage renal disease. Also, should be considered the most important chronic kidney because strong association with diabetes hypertension, two common etiologies end stage kidney Melatonin very close direct indirect...
In this study, we evaluated the effects of melatonin (Mel), leptin (Lep) or and treatment on ovaries in control obese rats. The animals were divided into (NC), (NM), (NL), melatonin–leptin (NML), (OC), obese–melatonin (OM), obese–leptin (OL), obese–melatonin–leptin (OML) groups. Body weights, peri-ovarian fat pads, volumetric parameters numerical values follicles estimated. Also, LH receptor (LHr) immune-positivity, catalase (CAT) myeloperoxidase (MPO) levels determined. body weight pads...
Background . The aim of the study was to evaluate whether or not there any incompatibility between four-strand hamstring tendons taken from same knee and dimensions ACL PCL. Methods 15 fresh frozen cadaver hamstrings were prepared as grafts measurements made PCL circumferences in midsection narrowest part midsection. cross-section areas diameters calculated with geometric calculations used measure cross-sectional area cylinders. Accepting that insertions elliptical, length, width, for entry...
Duchenne Muscular Dystrophy (DMD) results in a deficiency of dystrophin expression patient muscle fibers, leading to progressive degeneration. Treatment DMD has undertaken current transformation with the advancement novel gene therapy and molecular biology techniques, which are secure, well-tolerated, effective therapeutic approaches.DMD therapies have mainly focused on young patients as vivo animal model trials been performed 0-1-month mice. However, it not yet answered how micro-dystrophin...
Abstract COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, vaccines have become crucial reducing morbidity and mortality. In study, in vitro vivo safety efficacy analyzes of lyophilized candidates inactivated gamma-irradiation were performed. The candidate study OZG-3861 version 1 (V1), virus vaccine, SK-01 a GM-CSF adjuvant added vaccine. applied intradermally to BALB/c mice assess toxicity...
Abstract The SARS-CoV-2 virus caused the most severe pandemic around world, and vaccine development for urgent use became a crucial issue. Inactivated formulated vaccines such as Hepatitis A, oral polio vaccine, smallpox proved to be reliable approaches immunization prolonged periods. During pandemic, we produced an inactivated candidate, having advantages of being manufactured rapidly tested easily in comparison with recombinant vaccines. In this study, that includes gamma irradiation...
Obesity, is one of the most significant and common diseases today’s world. Leptin, one important adipose-derived hormones among best-known hormone markers for obesity it plays a key role in regulating stable body weight and is synthesized released by fat cells adipose tissue. So leptin has used obesity treatment. The aim this study; to detect effects high diet induced obesity and on liver using physical disector Cavalieri methods. This study was including four groups: Non-obese control,...
Objective: This study aimed to compare the effects of human umbilical cord mesenchymal stem cells (hUCMSCs), amniotic fluid (AF), and a combination both on uterus ovaries in rat model abdominal adhesions. Material Methods:This was designed as controlled study.Four groups, each consisting six rats, were randomly formed.One group designated control (CNT).hUCMSCs -applied (hUCSC), AF-applied (AMN), (hUCSC + AMN) experimental groups.All rats given intraperitoneal talc powder create...
Purpose This study aimed to evaluate whether cilostazol (phosphodiesterase III inhibitor) could enhance the healing of Achilles tendon ruptures in rats.
We sought to show the biomechanical and morphometric properties of flexor hallucis longus (FHL) digitorum (FDL) tendon grafts harvested by specific surgical approaches assess contribution FHL slips long tendons toes.Thirteen fresh-frozen amputated feet (average age, 79 years) were dissected. The connections between FDL classified. measured using a tensile device.The reviewed in two groups. Group 1 had (11 cases) group 2 cross-slips (two cases). joined second third toe structures. Tendon...
OBJECTIVE The aim of this study was to provide anatomic considerations in the first metatarsophalangeal joint (FMPJ) innervation and evaluate feasibility denervation surgery treatment hallux rigidus. METHODS In cadaveric study, 14 fresh frozen transtibial amputation specimens used. For nerve dissection, dorsal plantar longitudinal incision centered over FMPJ were performed. Deep peroneal dorsomedial cutaneous nerves dissected aspect joint. Medial branches, medial lateral hallucal nerves,...
Abstract Inflammation and neuronal loss are key factors in the pathophysiology of epilepsy. It is known that activation Dual Leucine Zipper Kinase (DLK) chronic neurodegenerative diseases causes neuron death axon degeneration through apoptotic pathways. Genetic deletion DLK (dual leucine zipper kinase, MAP3K12) or pharmacological inhibition by GNE-3511 GNE-8505 was found to have benefits mouse models Alzheimer’s ALS; however, there no previous study uses inhibitors epilepsy models....
Abstract Human amniotic fluid stem cell (hAFSC) exhibit significantly as a new treatment modality in hair loss, wound, scar and regenerative plastic surgery/dermatology. The difference of our study from previous studies on the growth model was studied through direct effect human (hAF). In study, made acellular, pooled freezed, making it more standardized terms its contents. Therefore, present is aimed at investigating efficacy safety loss rat. Using rats, we investigated therapeutic...
Abstract Background In people with diabetes, the effect of sleeve gastrectomy on impaired sperm parameters, hormonal profile and testis tissue remains controversial to some extent. The context purpose study Effects profile, in infertile men type II diabetes mellitus (TIIDM). This included thirty two TIIDM that were scheduled without gastrectomy. All rats taken a analysis, serum hormone before, 8 weeks after surgery. Results There was significant correlation between weight loss decreased...