A5050376668- RNA modifications and cancer
- Advanced Proteomics Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Retinal Diseases and Treatments
- Folate and B Vitamins Research
- Bladder and Urothelial Cancer Treatments
- RNA Research and Splicing
- Biotin and Related Studies
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Parkinson's Disease Mechanisms and Treatments
- Glaucoma and retinal disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Retinal Imaging and Analysis
- Electrospun Nanofibers in Biomedical Applications
- Monoclonal and Polyclonal Antibodies Research
- Periodontal Regeneration and Treatments
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
Kocaeli Üniversitesi
2016-2025
Pennsylvania State University
2010-2013
Bursa Uludağ Üni̇versi̇tesi̇
2001
Bayındır Hastanesi
1999
Defects in mitochondrial ribosomal proteins (MRPs) cause various diseases humans. Because of the essential role MRPs synthesizing subunits oxidative phosphorylation (OXPHOS) complexes, identifying all protein components involved translational machinery is critical. Initially, we identified 79 MRPs; however, with no clear homologs bacteria and yeast mitochondria was challenging, due to limited availability expressed sequence tags (ESTs) databases available at that time. With improvement...
The level of heterogeneity among the isolated stem cells makes them less valuable for clinical use. purpose this study was to understand human dental pulp derived mesenchymal by using basic cell biology and proteomic approaches. were from a natal (NDPSCs), an exfoliated deciduous (stem (SHED)), impacted third molar (DPSCs) tooth three different donors. All displayed similar features related morphology, proliferation rates, expression various surface markers, differentiation potentials into...
ABSTRACT Thymoquinone (TQ) has shown antitumorigenic effects in breast cancer; however, its detailed impact on cell signaling mechanisms requires further investigation. This study aims to elucidate the molecular behind TQ's antiproliferative cancer by analyzing proteome‐level changes. MCF‐7 cells were treated with 15 µM TQ, inhibitory concentration (IC50), for 48 h. Proteins from and untreated (control) groups isolated subjected liquid chromatography–tandem mass spectrometry (LC–MS/MS)...
ABSTRACT Mitochondria play a fundamental role in energy metabolism, particularly high‐energy‐demand tissues such as skeletal muscle. Understanding the proteomic composition of mitochondria these cells is crucial for elucidating mechanisms underlying muscle physiology and pathology. However, effective isolation from primary human has been challenging due to complex cellular architecture propensity contamination with other organelles. Here, we compared four different methods isolate myoblasts...
Background/Aim: Prostate cancer is the second leading cause of cancer-related deaths in men. Periodontitis considered a high-risk factor for prostate cancer, but genetic mechanism unclear. This study aims to identify dysregulated miRNAs, their associated genes, signaling pathways, and compounds linking periodontitis cancer. Materials Methods: The miRNA expression datasets were obtained from GEO database. Differentially expressed miRNAs (DEmiRNAs) identified, common DEmiRNAs (Co-DEmiRNAs)...
Small cell lung carcinoma (SCLC) is a highly aggressive cancer with low survival rate. Although initial response to chemotherapy in SCLC patients well-rated, the treatments applied after disease relapses are not successful. Drug resistance accepted be one of main reasons for this failure. Therefore, there an urgent need new treatment strategies SCLC. Meclofenamic acid, nonsteroidal anti-inflammatory drug, has been shown have anticancer effects on various types cancers via different...
It is well-known that diverse types of blood proteins contribute to healing process via different mechanisms. Presence and potential involvements blood-derived abundant in the platelet-rich fibrin (PRF) its regenerative capacity have not been sufficiently emphasized literature. The aim this paper was analyze proteome content PRF summarize previously reported effects identified on wound a literature review.The samples obtained from non-smoking, systemically healthy volunteers were subjected...
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of abnormal hepatic steatosis in absence a history alcohol use. steatohepatitis (NASH) progressive form NAFLD. Hyperhomocysteinemia causes steatosis, and methylenetetrahydrofolate reductase (MTHFR) C677T A1298C polymorphisms result hyperhomocysteinemia. To examine whether MTHFR gene were associated with NASH, we analysed allele genotype distribution 57 well-diagnosed NASH patients, 324 healthy controls case-control study...
ABSTRACT In this study, we aimed to investigate the potential use of keratin biofiber (KBF)‐reinforced biodegradable thermoplastic polyurethane (TPU) composites as tissue engineering scaffolds. The were prepared by a solution casting method. Combined salt leaching and thermally induced phase‐separation methods used manufacture porous scaffold structures. mechanical properties investigated with tensile tests dynamic analysis (DMA). An increase in fiber content increased modulus strength...
Background/Aim: Breast cancer (BC) incidence and mortality rates have been increasing due to the lack of appropriate diagnostic tools for early detection. Proteomics-based studies may provide novel targets diagnosis efficient treatment. The aim this study was investigate global changes occurring in protein profiles breast tissues discover potential or prognostic biomarkers. Materials Methods: BC their corresponding healthy counterparts were collected, subtyped, subjected comparative...
To unveil the pathophysiology of primary hyperparathyroidism, molecular details parathyroid hyperplasia and adenoma have to be revealed. Such will provide tools necessary for differentiation these two look-alike diseases. Therefore, in present study, a comparative proteomic study using postoperative tissue samples from patients was performed.Protein extracts were prepared (n=8 per group). Protein pools created each group subjected DIGE conventional 2DE. Following image analysis, spots...