Purpose: Breast cancers exhibit molecular heterogeneity, leading to diverse clinical outcomes and therapeutic responses. Immune checkpoint inhibitors targeting PD-L1 have shown promise in various malignancies, including breast cancer. Lipocalin 2 (LCN2) has also been associated with tumor aggressiveness prognostic potential cancers. However, the expression of LCN2 cancer subtypes their implications remains poorly investigated. Methods: A retrospective analysis 89 primary cases was conducted...

In women with unexplained infertility (UI) and recurrent in vitro fertilization (IVF) failures, the etiology is often unclear. Endometrial immune perturbations use of markers associated these dysregulations are great interest diagnosis treatment UI. However, reliable biomarkers standardized quantification methods lacking. Here, to address endometrial dysregulation UI patients IVF we performed tissue sampling immunostaining CD56 (uNK), CD138, BCL-6. Of cases, 57.9% had positive stroma, while...

Ovarian pregnancy (OP) after embryo transfer is very rare. Due to the rarity and asymptomatic nature, there are still difficulties in diagnosis treatment. The traditional operative treatment for OP has been oophorectomy. However, desire maintain reproductive capability improvements laparoscopy have more recently led conservative laparoscopic techniques. This rare complication could be diagnosed early managed by a approach. Here we present survey of literature case successful management...

Schwannomas are common, well-encapsulated benign tumors of the peripheral nerves. They rarely emerge from median nerve in forearm. Here we report a case an unusual schwannoma measuring 3 × 4 cm originating proximal forearm 49-year-old man. The mass was painless, but Tinel's sign positive. Ultrasonography showed solid, hypoechoic with central cystic areas flexor muscle group left Magnetic resonance imaging contrast enhancement T1 sequences revealed that it originated nerve. Surgical resection...

Chronic bone loss is an under-recognized complication of malaria, the underlying mechanism which remains incompletely understood. We have previously shown that persistent accumulation Plasmodium products in marrow leads to chronic inflammation osteoblast (OB) and osteoclast (OC) precursors causing through MyD88, adaptor molecule for diverse inflammatory signals. However, specific contribution MyD88 signaling OB or OC malaria-induced elusive. To assess direct cell-intrinsic role adult...

İstismara bağlı kafa travması, çocuğun şiddetli sarsılması ve/veya künt travmaya maruz kalması sonucu kafatası ve beyin dokusu hasarına yol açan ciddi bir çocuk istismarı tipidir.Sıklıkla 2 yaş altı olmak üzere 5 çocuklarda görülür.Klasik üçlü bulgusu; subdural hematom, retina kanaması ensefalopatinin eş zamanlılığıdır.Ölümle sonuçlanan olgularda ölüm nedeninin lezyonların yaşının belirlenmesinde otopsideki histopatolojik immünohistokimyasal incelemeler çok önemlidir.Bu makroskobik tanının...

BACKGROUND/AIMS: Endocervical adenocarcinoma (ECA) accounts for 25% of cervical cancers and is clinically more aggressive than squamous cell carcinoma (SCC).Similarly, SCC ECA can be treated without the formation invasive tumors if precursor lesions are identified accordingly.The objective this study to analyze effectiveness screening tests in detection endocervical situ (AIS), which represents a lesion ECA. MATERIALS AND METHODS:The comprised total 121 cases, including 83 cases 38 AIS,...

Leishmaniasis, a parasitic infection affecting both humans and animals, is increasingly spreading across Mediterranean European regions, largely driven by human migration environmental changes. In countries like Türkiye Europe, which have seen large influxes of migrants, the incidence cutaneous leishmaniasis (CL) rising, with cases now appearing in cities where disease was previously undocumented. these non-endemic areas, physicians unfamiliar characteristic lesions may misdiagnose CL,...

Testicular myoid gonadal stromal tumors (MGSTs) are rare neoplasms. While past research has detailed the pathological characteristics of these tumors, radiological differences between MGST and other types testicular have not been elucidated. Our study aimed to reveal possible distinctive features using magnetic resonance imaging (MRI). We report a 24-year-old patient presenting with left scrotal mass. During patient’s preoperative MRI, we observed tumor measuring 2.5 cm that was consistent...

Malaria is known to cause acute and deadly complications. However, malaria can unforeseen pathologies due its chronicity. It increases the risk of endemic Burkitt Lymphoma development by inducing DNA damage in germinal centre (GC) B cells, leading higher frequency Epstein–Barr virus (EBV)-infected cells GCs. EBV well for tropism cells. less about EBV's interaction with T association cell lymphoma. A 43-year-old Sudanese male admitted hospital Istanbul, Turkey, a non-endemic country,...

Abstract We aimed to report a detection failure of sentinel lymph node (SLN) mapping via indocyanine green in patient with endometrial cancer previous history chronic lymphocytic leukemia (CLL), which is potential risk factor obstruct lymphatic channels. A 64‐year‐old woman 12‐year CLL presented the clinic grade 2 endometrioid carcinoma. The underwent laparoscopic surgical staging. Indocyanine was used intraoperatively locate SLN. No or vessels were identified during SLN mapping. At final...

A 34-year-old male patient who had left orchiectomy and received three cycles of chemotherapy for testicular mix germ cell carcinoma was referred 18 fluorine-fluorodeoxyglucose ( F-FDG) positron emission tomography/computed tomography (PET/CT) complaints weight loss fever.PET/CT showed multiple progressive F-FDG uptakes in supra infra diaphragmatic lymphatic regions, abnormal were noted the lytic formed skeletal lesions.Clinicians remain doubt regarding metastatic lesions without elevated...

Verruciform xanthoma (VX), a significantly rare benign skin lesion, is often confused with other malignant and lesions due to its macroscopic clinical appearance.A 35-year-old female patient was admitted the general surgery clinic VX lesion on her nipple.The subject excision suspected malignancy.As far as we are aware, this only case in which found nipple of patient.Multiple similar appearances were accompanied by history lactation, mastitis breast lesion.We aimed discuss unique rarity,...

Introduction: Cervical cancer is one of the most common cancers in women. Precancerous lesions cervix can be detected with combined use smear testing and HPV (Human Papillomavirus) testing. International guidelines have been developed to indicate at what intervals which situations tests should performed. In this study, we examined clinical utility screening patients histopathologically diagnosed SCC (squamous cell carcinoma) HSIL. Metods: Between January 2022 June 2023, 447 aged 19-73 years...

Objective: Atherosclerosis is a generalized, chronic disease of large and medium-sized muscular elastic arteries. Relation between intensity atherosclerosis coronary artery disease, risk factors could not been revealed completely by autopsy studies. We aimed to renew this shortage knowledge with our study prospectively. 
 Methods: One hundred cases were autopsied within 48 h after death. Atherosclerotic factor data collected including age, gender, height, weight, smoking any disease....

Abdominal pregnancy is of ectopic gestation with a incidence maternal morbidity and mortality.Ultrasonography βhCG levels are useful for early detection pregnancy.Meticulous surgical exploration crucial the definitive diagnosis in abdominal pregnancy.Abdominal an extraordinary presentation summarized current case report.Seven weeks pregnant patient complained pain was diagnosed as according to results ultrasonography.Laparoscopic findings were consistent normal uterus, bilateral adnexae...

Abstract Objective: In recent literature, increasing number of studies have analyzed associations between the MRI findings and histopathological features breast cancer. Ki-67 index is an important prognostic factor in cancer which provides information about mitotic activity growth rate tumor. The proliferation markers like PHH3 (Phosphohistone H3) play role decision making treatment regimes. a relatively new entity specific only to giving it unique characteristic because not observed at...

Abstract Purpose: Inter- and intra-observer variability adversely affects interpretation of highly advantageous MRI data in breast cancer diagnosis, prognosis therapeutic decisions. Machine learning (ML) might potentially provide support to the physicians for objective decision strategies. In this work, ML methods using BI-RADS features were tested non-invasively determining molecular subtypes cancer. Methods: IRB approved study, Out 126 consecutive patients' retrospective with written...

Endometrial polyps may be detected by transvaginal ultrasonography TVS in early pregnancy. These pregnancies end with fetal demise. There are not enough data literature defining term labor pregnancy endometrial polyp. The current case describes detail, the progress of a polyp including growth, regression polyp, assessment placental pathology and postpartum follow-up. Giant protruding into uterine cavity adjacent to gestational sac was 31 year-old-primigravida. She delivered healthy baby...

Amaç: Safra kesesi adenomyomatozisinin (SKA) kesin patogenezi hala tam olarak açıklanamamıştır, tanı ve tedavisine ilişkin bazı tartışmalar mevcut. Başlangıçta kanser öncesi bir lezyon kabul edilen adenomyomatozis, son zamanlarda yapılan çalışmalarda safra kesesinin sıklıkla kolesistit kolelitiazis ile ilişkili iyi huylu değişikliği edilmektedir. Bu çalışmada, SKA patogenezini araştırmak için; aynı hastada normal adenomyomatozis dokusunda, tümör hücrelerinin proliferatif aktivitesini...