A5062496756- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Trauma and Emergency Care Studies
- Cerebrospinal fluid and hydrocephalus
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Child Abuse and Related Trauma
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory Support and Mechanisms
- Traumatic Brain Injury Research
- Pneumonia and Respiratory Infections
- Abdominal Trauma and Injuries
- Intraoperative Neuromonitoring and Anesthetic Effects
- Long-Term Effects of COVID-19
- Pituitary Gland Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Anesthesia and Sedative Agents
- S100 Proteins and Annexins
- Spine and Intervertebral Disc Pathology
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
University Medical Center Hamburg-Eppendorf
2016-2025
Universität Hamburg
2016-2025
Klinik und Poliklinik für Neurologie
2022
Asklepios
2021
Witten/Herdecke University
2021
Asklepios Klinik St. Georg
2021
After aneurysmal subarachnoid hemorrhage, the use of lumbar drains has been suggested to decrease incidence delayed cerebral ischemia and improve long-term outcome.To determine effectiveness early cerebrospinal fluid drainage added standard care in patients after hemorrhage.The EARLYDRAIN trial was a pragmatic, multicenter, parallel-group, open-label randomized clinical with blinded end point evaluation conducted at 19 centers Germany, Switzerland, Canada. The first patient entered January...
OBJECTIVE Prediction of death and functional outcome is essential for determining treatment strategies allocation resources patients with severe traumatic brain injury (TBI). The aim this study was to evaluate, by using pupillary status Glasgow Coma Scale (GCS) score, if TBI who are ≤ 15 years old have a lower mortality rate better than adults TBI. METHODS A retrospective cohort analysis suffering from registered in the Trauma Registry German Society Surgery between 2002 2013 undertaken....
Abstract Background Aneurysmal subarachnoid hemorrhage (SAH) as a serious type of stroke is frequently accompanied by so-called initial thunderclap headache. However, the occurrence burdensome long-term headache following SAH has never been studied in detail so far. The aim this study was to determine prevalence and characteristics good-grade patients well its relation health-related quality life (HR-QOL). Methods All cases treated between January 2014 December 2016 with preserved...
The evolution of intracranial pressure (ICP) critically ill patients admitted to a neurointensive care unit (ICU) is difficult predict. Besides the underlying disease and compromised space, ICP affected by multitude factors, many which are monitored on ICU, but complexity resulting patterns limits their clinical use. This paves way for new machine learning techniques assist management undergoing invasive monitoring independent disease. An institutional cohort (ICP-ICU) with (n = 1346) was...
In patients with traumatic brain injury (TBI), adequate oxygenation is crucial to optimize survival and neurological outcome. However, supranormal oxygen partial pressure (PaO2) only leads minor increase in cerebral delivery but can cause numerous pathophysiological disturbances. Therefore, we aimed study effects of hyperoxia on patient outcome identify optimum PaO2 ranges. This retrospective, single-center cohort included TBI receiving mechanical ventilation for ≥ 72 h. Time-weighted mean...
Background and purpose The role of corticosteroids in the treatment patients with aneurysmal subarachnoid haemorrhage ( SAH ) has remained controversial for decades. Recent studies have suggested that administration is associated favourable outcomes. Given their significant adverse effects, it essential to identify those who will benefit from corticosteroids. Methods A retrospective analysis a prospectively collected cohort n = 306) were treated by microsurgical clipping or endovascular...
OBJECTIVE Decompressive craniectomy (DC) is an established part of treatment in patients suffering from malignant infarction the middle cerebral artery (MCA) or traumatic brain injury (TBI). However, no clear evidence for intracranial pressure (ICP)-guided therapy after DC exists. The lack this might be due to frequently used, but simplified threshold ICP 20 mm Hg, which determines further therapy. Therefore, objective study was evaluate threshold's accuracy and investigate course values...
Abstract Background Adequate oxygenation in patients with aneurysmal subarachnoid hemorrhage (SAH) is imperative. However, hyperoxia increases formation of reactive oxygen species and may be associated a dose-dependent toxicity. We postulated threshold for arterial partial pressure (paO 2 ) above which toxicity effects precipitate sought to study the on 30-day mortality, favorable outcome at discharge 3 months, delayed cerebral ischemia. Methods In this retrospective single-center cohort...
Although unconsciousness (Glasgow Coma Scale [GCS] 3 to 8) necessitates intubation according national guidelines, there is a notable lack of evidence support this approach. This study evaluates the impact on outcome prehospital with and without sedation in trauma patients GCS ≤8.A retrospective cohort analysis severely injured registered TraumaRegister DGU German Trauma Society (DGU) from 2002 2013 was conducted. Only directly admitted alive admission ≤8 at scene were included. The observed...
Abstract Prognosis of patients with high-grade aneurysmal subarachnoid hemorrhage (aSAH) is only insufficiently displayed by current standard prognostic scores. This study aims to evaluate the role pupil status for mortality prediction and provide improved models. Anonymized data 477 aSAH admitted our medical center from November 2010 August 2018 were retrospectively analyzed. Identification variables independently predicting in-hospital was performed multivariable logistic regression...
Rationale: Aneurysmal subarachnoid hemorrhage (SAH) has high morbidity and mortality. While the primary injury results from initial bleeding cannot currently be influenced, secondary through vasospasm delayed cerebral ischemia worsens outcome might a target for interventions to improve outcome. To date, beside aneurysm treatment prevent re-bleeding administration of oral nimodipine, there is no therapy available, so novel concepts are needed. Evidence suggests that inflammation contributes...
In absence of comprehensive data collection on traumatic brain injury (TBI), the German Society for Neurosurgery (DGNC) and Trauma Surgery (DGU) developed a TBI databank German-speaking countries.From 2016 to 2020, DGNC/DGU was implemented as module TraumaRegister (TR) DGU tested in 15-month pilot phase. Since its official launch 2021, patients from TR-DGU (intermediate or intensive care unit admission via shock room) with (AIS head ≥ 1) can be enrolled. A set > 300 clinical, imaging,...
Abstract Aneurysmal subarachnoid haemorrhage (aSAH) can lead to complications such as acute hydrocephalic congestion. Treatment of this condition often includes establishing an external ventricular drainage (EVD). However, chronic hydrocephalus develops in some patients, who then require placement a permanent ventriculoperitoneal (VP) shunt. The aim study was employ recurrent neural network (RNN)-based machine learning techniques identify patients VP shunt at early stage. This retrospective...