A5084437551- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Brain Metastases and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Epilepsy research and treatment
- Spine and Intervertebral Disc Pathology
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Infectious Diseases and Tuberculosis
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Sinusitis and nasal conditions
- Peripheral Artery Disease Management
- Neuroscience and Neuropharmacology Research
- Head and Neck Surgical Oncology
- Vascular Procedures and Complications
- Musculoskeletal pain and rehabilitation
- Respiratory Support and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Pharmacological Effects and Toxicity Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced MRI Techniques and Applications
- Orthopedic Infections and Treatments
University of Augsburg
2021-2025
University Hospital Augsburg
2020-2024
Universitätsklinikum Erlangen
2013-2024
Royal College of Art
2022
ZHAW Zurich University of Applied Sciences
2022
Universitätsmedizin Göttingen
2021
Friedrich-Alexander-Universität Erlangen-Nürnberg
1971-2018
University of Freiburg
2018
University of Konstanz
2017
Universität Hamburg
2014
Abstract Integrin-based therapeutics have garnered considerable interest in the medical treatment of inflammation. Integrins mediate fast recruitment monocytes and neutrophils to site inflammation, but are also required for host defense, limiting their therapeutic use. Here, we report a novel monoclonal antibody, anti-M7, that specifically blocks interaction integrin Mac-1 with its pro-inflammatory ligand CD40L, while not interfering alternative ligands. Anti-M7 selectively reduces leukocyte...
The authors performed a retrospective study to assess the impact of functional neuronavigation and intraoperative MRI (iMRI) on surgery extratemporal epileptogenic lesions postsurgical morbidity seizure control.Twenty-five patients (14 females 11 males) underwent resections for drug-resistant epilepsy close speech/motor brain areas or adjacent white matter tracts. mean age at was 34 years (range 12-67 years). preoperative disease duration 13.2 years. To avoid awake craniotomy, cortical...
Background: Recent evidence suggests that alternative postoperative surveillance approaches for patients undergoing elective neurosurgical procedures are less resource-intensive and result in similar or fewer complications compared to high-care settings such as Intensive Care Units (ICUs). A new care protocol was established at our facility including routine PACU admission predefined criteria ICU admission. We aimed demonstrate is a safe option craniotomy following eventless surgery....
External-beam radiotherapy (EBRT) is the predominant method for localized brain (LBRT) after resection of metastases (BM). Intraoperative (IORT) with 50-kV x‑rays an alternative way to focally irradiate cavity BM surgery, option shortening overall treatment time and limiting normal tissue irradiation.
OBJECTIVE There is no established method of noninvasive intracranial pressure (NI-ICP) monitoring that can serve as an alternative to the gold standards invasive with external ventricular drainage or intraparenchymal monitoring. In this study a new NI-ICP performed using algorithms determine ICP based on acoustic properties brain was applied in patients undergoing (I-ICP) monitoring, and results were analyzed. METHODS traumatic injury subarachnoid hemorrhage who treatment neurocritical...
OBJECT Cerebral gangliogliomas (GGs) are highly associated with intractable epilepsy. Incomplete resection due to proximity eloquent brain regions or misinterpretation of the amount is a strong negative predictor for local tumor recurrence and persisting seizures. A potential method dealing this obstacle could be application intraoperative high-field MRI (iopMRI) combined neuronavigation. METHODS Sixty-nine patients (31 female, 38 male; median age 28.5 ± 15.4 years) suffering from cerebral...
In absence of comprehensive data collection on traumatic brain injury (TBI), the German Society for Neurosurgery (DGNC) and Trauma Surgery (DGU) developed a TBI databank German-speaking countries.From 2016 to 2020, DGNC/DGU was implemented as module TraumaRegister (TR) DGU tested in 15-month pilot phase. Since its official launch 2021, patients from TR-DGU (intermediate or intensive care unit admission via shock room) with (AIS head ≥ 1) can be enrolled. A set > 300 clinical, imaging,...
The coincidence of inflammation and metabolic derangements in obese adipose tissue has sparked the concept met-inflammation. Previous observations, however, suggest that inflammatory pathways may not ultimately cause dysmetabolism.We have revisited relationship between metabolism by testing role TRAF (tumor necrosis receptor-associated factor)-1, an inhibitory adapter signaling TNF factor)-α, IL (interleukin)-1β, TLRs (toll-like receptors).Mice deficient for TRAF-1, which is expressed...
Especially in hidden lesions causing drug-resistant frontal lobe epilepsy (FLE), the localization of epileptic zone EZ can be a challenge. Magnetoencephalography (MEG) raise chances for (EZ) combination with electroencephalography (EEG). We investigated impact MEG-guided surgery aid neuronavigation and intraoperative MR imaging (iopMRI) on seizure outcome FLE patients.Twenty-eight patients (15 females, 13 males; mean age 31.0±11.1 years) underwent our department. All presurgical MEG...
Current treatment of spinal metastases (SM) aims on preserving stability, neurological status, and functional status as well achieving local control. It consists surgery followed by radiotherapy and/or systemic treatment. Adjuvant therapy usually starts with a delay few weeks to prevent wound healing issues. Intraoperative (IORT) has previously been successfully applied during brain tumor, breast colorectal carcinoma but not in SM, including unstable one, date. In our case series, we...
Epilepsy surgery for focal cortical dysplasia type II (FCD II) offers good chances seizure freedom, but remains a challenge with respect to lesion detection, defining the epileptogenic zone and optimal resection strategy. Integrating results from magnetic source imaging magnetoencephalography (MEG) resonance (MRI) including MRI postprocessing may be useful optimizing these goals. We here present data 21 adult FCD patients, investigated during 10 year period evaluated imaging. 16 patients had...
Invasive listeriosis most often presents as bacteremia or neurolisteriosis. Cerebral infection mostly manifests meningitis meningoencephalitis, but cerebral abscesses are a rare manifestation.We present the case of 51-year old patient with progressive right sided hemiparesis caused by abscess due to Listeria monocytogenes infection. The initially suspected ischemia bleeding was ruled out. Magnetic resonance imaging led diagnosis an angiocentric lymphoma. An open biopsy revealed intracranial...
Surgical management of spinal metastases at the cervicothoracic junction (CTJ) is highly complex and relies on case-based decision-making. The aim this multicentric study was to describe surgical procedures for CTJ provide guidance clinical management.Patients eligible were those with (C7-T2) who had been consecutively treated in 2005-2019 7 academic institutions across Europe. Spine Instability Neoplastic Score, neurological function, status, medical history, data each patient...
Magnesium sulfate (MgSO
Abstract Non-aneurysmal subarachnoid hemorrhage (NASAH) is rare and mostly benign. However, complications such as cerebral vasospasm (CV), delayed ischemia (DCI), or post-hemorrhagic hydrocephalus (HC) may worsen the prognosis. The aim of this study was to evaluate rate these comparing perimesencephalic (PM) non-perimesencephalic (NPM) SAH. Monocentric, retrospective analysis patients diagnosed with NASAH from 01/2010 01/2021. Diagnosis set only if vascular pathologies were excluded in at...
Starting in November 2003 a series of five clinical cases canine babesiosis was registered the region Obergösgen (canton Solothurn). All presented dogs showed increased body temperature, thrombocytopenia and hemoglobinuria, none had been abroad or visited endemic regions southern western part Switzerland so far. Babesia canis detected blood smears all patients, but only three detectable specific antibodies against this parasite. However, seroconversion found second sample collected from...
We investigated mechanical pull-out behavior and tightening torque of a novel dual-core pedicle "6T screw" (6T). The aim this study was to test if these changes in screw geometry are increasing the strength fixation after repeated insertion.Three different types screws were inserted rigid foam blocks. Tightening measured during two repetitive insertions standard 6.5×45-mm conical screw. third insertion into pilot hole performed using either or 7.2×45-mm (6T) Additionally, we surface analysis...