A5043065066- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Spinal Fractures and Fixation Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Spine and Intervertebral Disc Pathology
- Glioma Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- S100 Proteins and Annexins
- Advanced MRI Techniques and Applications
- Renin-Angiotensin System Studies
- Intensive Care Unit Cognitive Disorders
- Vitamin K Research Studies
- Pain Mechanisms and Treatments
- Periodontal Regeneration and Treatments
- Thermal Regulation in Medicine
- Burkholderia infections and melioidosis
- Myofascial pain diagnosis and treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Botulinum Toxin and Related Neurological Disorders
- Brucella: diagnosis, epidemiology, treatment
Universitätsklinikum Würzburg
2014-2025
Penn State Milton S. Hershey Medical Center
2024
University of Würzburg
2012-2023
Klinik und Poliklinik für Neurologie
2021
University Medical Center Freiburg
2000
Universitätskinderklinik
1992
To examine whether the maintenance of elevated magnesium serum concentrations by intravenous administration sulfate can reduce occurrence cerebral ischemic events after aneurysmal subarachnoid hemorrhage.Prospective, randomized, placebo-controlled study.Neurosurgical intensive care unit a University hospital.One hundred ten patients were randomized to receive or serve as controls. Magnesium treatment was started with bolus 16 mmol, followed continuous infusion 8 mmol/hr. Serum measured every...
Traumatic brain injury (TBI) is a major cause of death and disability. Neuroinflammation contributes to acute damage after TBI modulates long-term evolution degenerative regenerative responses injury. The aim the present study was evaluate relationship microglia activation trauma severity, energy metabolism, cellular reactions in mouse closed head model using combined vivo PET imaging, ex autoradiography, immunohistochemistry. A weight-drop used produce mixed diffuse focal or purely mild...
Traumatic brain injury (TBI) is a devastating neurological condition and frequent cause of permanent disability. Posttraumatic inflammation edema formation, two pathological key events contributing to secondary injury, are mediated by the contact-kinin system. Activation this pathway in plasma triggered activated factor XII. Hence, we set out study detail influence XII on abovementioned pathophysiological features TBI. Using cortical cryogenic lesion model mice, investigated impact genetic...
Abstract Aneurysmal subarachnoid hemorrhage (aSAH) is a debilitating condition with significant morbidity and mortality rates. Despite advancements in treatment, understanding the underlying pathophysiology, particularly inflammatory response, remains crucial for improving patient outcomes. In this study, we investigated presence of transmembrane protein 119 (TMEM119) microglial cells cerebrospinal fluid (CSF) as potential marker neuroinflammation following aSAH. CSF samples were collected...
This article reviews experimental and clinical data on the use of magnesium as a neuroprotective agent in various conditions cerebral ischemia. Whereas has shown properties animal models global focal ischemia, this effect could not be reproduced large human stroke trial. These conflicting results may explained by timing treatment. While treatment can started before or early after ischemia studies, there is an inevitable delay stroke. Magnesium administration to women at risk for preterm...
Abstract In this multicenter cross-sectional study, we determined sensory profiles of patients with (NL-1) and without neuropathic pain (NL-0) after nerve lesion assessed immune-related systemic gene expression. Patients matched healthy controls filled in questionnaires underwent neurological examination, neurophysiological studies, quantitative testing, blood withdrawal. Neuropathic was present 67/95 (71%) (NL-1). Tactile hyperalgesia the most prominent clinical sign NL-1 ( P < 0.05)....
The authors undertook this study to investigate whether the physiological mechanism of cerebral blood flow (CBF) regulation by alteration arterial partial pressure carbon dioxide (PaCO₂) can be used increase CBF after aneurysmal subarachnoid hemorrhage (aSAH).In 6 mechanically ventilated patients with poor-grade aSAH, PaCO₂ was first decreased 30 mm Hg modification respiratory rate, then gradually increased 40, 50 and 60 for 15 minutes each setting. Thereafter, respirator settings were...
The two bradykinin receptors B1R and B2R are central components of the kallikrein–kinin system with different expression kinetics binding characteristics. Activation these by kinins triggers inflammatory responses in target organ most situations enhances tissue damage. We could recently show that blocking B1R, but not B2R, protects from cortical cryolesion reducing inflammation edema formation. In present study, we investigated role a closed head model focal traumatic brain injury (TBI;...
Traumatic brain injury is a major global public health problem for which specific therapeutic interventions are lacking. There is, therefore, pressing need to identify innovative pathomechanism-based effective therapies this condition. Thrombus formation in the cerebral microcirculation has been proposed contribute secondary damage by causing pericontusional ischemia, but previous studies have failed harness finding use. The aim of study was obtain preclinical evidence supporting hypothesis...
Background. If detected in time, delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) may be treated by balloon angioplasty or chemical vasospasmolysis order to enhance blood flow (CBF) and protect the brain from ischemic damage. This study was conceived compare diagnostic accuracy of detailed neurological examination, Transcranial Doppler Sonography (TCD), Perfusion-CT (PCT) detect angiographic vasospasm. Methods. The sensitivity, specificity, positive negative...
One of the longest-standing treatments to prevent delayed cerebral infarction (DCI) in patients with aneurysmal subarachnoid hemorrhage (aSAH) remains raising blood pressure a certain level mean arterial pressure. This may require high doses norepinephrine, which has been associated severe end organ damage. With this study, we aimed investigate effects norepinephrine on incidence DCI clinical setting.We conducted retrospective evaluation aSAH admitted our institution between November 2018...
In absence of comprehensive data collection on traumatic brain injury (TBI), the German Society for Neurosurgery (DGNC) and Trauma Surgery (DGU) developed a TBI databank German-speaking countries.From 2016 to 2020, DGNC/DGU was implemented as module TraumaRegister (TR) DGU tested in 15-month pilot phase. Since its official launch 2021, patients from TR-DGU (intermediate or intensive care unit admission via shock room) with (AIS head ≥ 1) can be enrolled. A set > 300 clinical, imaging,...
Severe brain edema is observed in a number of patients suffering from subarachnoid hemorrhage (SAH). Little known about its pathogenesis and time-course the first hours after SAH. This study was performed to investigate development correlation with perfusion experimental Male Sprague–Dawley rats, randomly assigned one six groups (n = 8), were subjected SAH using endovascular filament model or underwent sham operation. Animals sacrificed 15, 30, 60, 180 360 minutes Intracranial pressure...
OBJECT Anterior cervical corpectomy with fusion has become the most widely used procedure for treatment of multilevel stenosis. Although an autologous bone graft is gold standard vertebral replacement after corpectomy, industrial implants have popular because they result in no donor-site morbidity. In this study, authors compared clinical and radiological results iliac grafts versus those bone-filled polyetherketoneketone (PEKK) cage implants. METHODS The data 46 patients degenerative...
Healing of venous leg ulcers depends on the adhesive interaction and formation new vascular cells. Angiogenesis surface angiogenic blood vessels requires integrin alphavbeta3 also known as vitronectin receptor. Autologous platelet-derived wound healing factor (autologous PDWHF) has been described to regulate process by forming granulation tissue in early phase. Here we analysed influence autologous PDWHF expression specimen comparison with placebo treated controls using reverse...
Abstract Delayed cerebral infarction (DCI) is a major cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). The benefits magnesium sulfate as an alternative treatment are controversial, most previous studies examined its only adjunctive to traditional nimodipine. We retrospectively analyzed aSAH records between 2010 2021. aimed for serum concentration 2–2.5 mmol/l post-hemorrhage days 3 12. were separated three groups based on average (magnesium >2...
Recent reports have doubted the efficacy and safety of hydroxyethyl starch (HES) for volume resuscitation. HES has been reported to promote renal insufficiency particularly in sepsis trauma patients. This analysis investigated effects 6% 130/0.4 fluid therapy patients with intact function who suffered aneurysmal subarachnoid hemorrhage (SAH).This retrospective included 107 was conducted framework a clinical trial assessing magnesium sulfate SAH. Because is renally eliminated, had excluded....
Object: Several previous studies reported metabolic derangements and an accumulation of products in the early phase experimental subarachnoid hemorrhage (SAH), which may contribute to secondary brain damage. This be a result deranged oxygen utilization due enzymatic dysfunction aerobic glucose metabolism. study was performed investigate, if pyruvate dehydrogenase enzyme (PDH) is affected its activity giving further hints for derangement oxidative Methods: Eighteen male Sprague-Dawley rats...
Mobile 3D fluoroscopes have become increasingly available in neurosurgical operating rooms. In this series, the image quality and value of intraoperative fluoroscopy with intravenous contrast agent for evaluation aneurysm occlusion vessel patency after clip placement was assessed patients who underwent surgery intracranial aneurysms. Twelve were included retrospective analysis. Prior to surgery, a 360° rotational scan performed without followed by another 50 ml iodine agent. The files both...
Temporary hypercapnia has been shown to increase cerebral blood flow (CBF) and might be used as a therapeutical tool in patients with severe subarachnoid hemorrhage (SAH). It was the aim of this study investigate optimum duration hypercapnia. This point is assumed time at which buffer systems become active, cause an adaptation changes arterial partial pressure carbon dioxide (PaCO2) annihilate possible therapeutic effect. In prospective interventional neurosurgical ICU increased target range...