A5021968885- Automotive and Human Injury Biomechanics
- Traumatic Brain Injury and Neurovascular Disturbances
- Elasticity and Material Modeling
- Hip disorders and treatments
- Sports injuries and prevention
- Autopsy Techniques and Outcomes
- Forensic Entomology and Diptera Studies
- Traumatic Ocular and Foreign Body Injuries
- Craniofacial Disorders and Treatments
- Lower Extremity Biomechanics and Pathologies
- Reconstructive Surgery and Microvascular Techniques
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Traumatic Brain Injury Research
- Facial Trauma and Fracture Management
- S100 Proteins and Annexins
- Pelvic and Acetabular Injuries
- Foot and Ankle Surgery
- Tendon Structure and Treatment
- Bone fractures and treatments
- Endodontics and Root Canal Treatments
- Spine and Intervertebral Disc Pathology
- Paleopathology and ancient diseases
- Cerebrospinal fluid and hydrocephalus
- Anatomy and Medical Technology
University Medical Center Hamburg-Eppendorf
2021-2025
Universität Hamburg
2021-2025
University of Otago
2018-2025
Leipzig University
2016-2022
American Academy of Forensic Sciences
2021
Institute of Forensic Science
2021
Abstract Realistic human head models are of great interest in traumatic brain injury research and the forensic pathology courtroom teaching. Due to a lack biomechanical data, dura mater is underrepresented models. This study provides tensile data 73 fresh cranial samples retrieved from an area between anterior middle posterior meningeal artery. Tissues were adapted their native water content using osmotic stress technique. Tensile tests conducted under quasi-static uniaxial testing...
To investigate load-deformation properties of Thiel-embalmed human oral mucosa tissues and to compare three different anatomical regions in terms mechanical, histological ultrastructural characteristic with focus on the extracellular matrix.Thirty specimens from cavity: attached gingiva, buccal hard palate were harvested two cadavers. Mechanical obtained, combining strain evaluation digital image correlation a standardised approach. Elastic modulus, tensile strength, at maximum load failure...
Embalming fixatives such as formaldehyde and phenol have been associated with occupational health hazards. While anatomists aim at replacing these chemicals, this seems presently unfeasible in particular for formaldehyde. Furthermore, fixation protocols usually require well‐equipped facilities highly experienced staff to achieve good results spite of only a minimal use Combining aspects, technique robust enough be carried out by morticians is presented, resulting durable tissues use. An...
Glial fibrillary acidic protein (GFAP) is a well-established astrocytic biomarker for the diagnosis, monitoring and outcome prediction of traumatic brain injury (TBI). Few studies stated an accumulation neuronal GFAP that was observed in various pathologies, including injuries. As immunopositivity Alzheimer patients shown to cross-react with non-GFAP epitopes, TBI should be challenged. In this study, cerebral cerebellar tissues 52 fatalities 17 controls were screened neurons by means...
Abstract Aneurysmal subarachnoid hemorrhage (aSAH) is a debilitating condition with significant morbidity and mortality rates. Despite advancements in treatment, understanding the underlying pathophysiology, particularly inflammatory response, remains crucial for improving patient outcomes. In this study, we investigated presence of transmembrane protein 119 (TMEM119) microglial cells cerebrospinal fluid (CSF) as potential marker neuroinflammation following aSAH. CSF samples were collected...
Abstract Crosado-embalming has been successfully used as embalming technique in research and teaching for over 20 years. It is applied biomechanical testing experiments if the fresh tissues are unavailable, e.g., cultural, ethical, logistical or health safety reasons. However, features of human Crosado-embalmed characteristics including its load-deformation properties comparison to controllability through hydration fluids may be insightful therefore need studied further. This study compared...
Knowledge on trauma survival time prior to death following a lethal traumatic brain injury (TBI) may be essential for legal purposes. Immunohistochemistry studies might allow narrow down this interval. The biomarkers interleukin-6 (IL-6) and glial fibrillary acidic protein (GFAP) are well known in the clinical setting their usability TBI prediction. Here, both proteins were chosen forensics determine whether neuronal or expression various regions associated with cause of TBI. IL-6 positive...
The subthalamic nucleus (STN) is a main target structure of deep brain stimulation (DBS) in idiopathic Parkinson's disease.Nevertheless, there an ongoing discussion regarding human STN volumes and neuron count, which could potentially have impact on STN-DBS.Moreover, suspected functional subdivision forms the basis tripartite hypothesis, has not yet been morphologically substantiated.In this study, it was aimed to investigate by means combined magnetic resonance imaging (MRI) stereology.STN...
Abstract The significance of biomechanical analyses for forensic time since death estimations has recently been demonstrated. Previous successfully discriminated post-mortem brain tissue from with a interval at least one day when held 20 °C. However, the practical utility such beyond °C was limited. This study investigates storage, loss, and complex shear modulus various regions in sheep stored 4 24-hour intervals over four days using rheometry tests. aim is to identify critical property...
Thiel embalming is a well-known method of anatomical fixation giving lifelike optical and haptic tissue properties. Beyond these characteristics, may also be promising to provide tissues for validation purposes human head biomechanics. Recent investigations using Thiel-embalmed the upper lower limb yielded contradicting biomechanical results on fixation-induced changes in tissues' load-deformation behavior. It date unclear if have softening or stiffening effect soft no global biomechanics...
Abstract Highly regular aligned trabeculae are found in the superficial posterior and inferior calcaneus appearing to connect Achilles tendon (AT) plantar fascia (PF) a bridge-like manner. This provides morphological basis for stretching-based heel pain treatment. However, continuity of collagen fibres between AT PF remains debated controversially date. The given study morphologically investigated AT-calcaneus-PF complex using histology plastination. Moreover, was biomechanically mapped...
Biomechanical testing of soft tissues forms the backbone in experimental validation tissue engineering and for modelling purposes. The standardized requires different protocols fixtures compared to hard or non-biological materials due their characteristics. Some most commonly-used clamping methods affect tissues' mechanical properties as chemicals are involved decelerate degradation autolysis. Moreover, they unsuitable high-throughput testing. Material slippage is also a recurrent unwanted...
Diagnosing traumatic brain injury (TBI) from body fluids in cases where there are no obvious external signs of impact would be useful for emergency physicians and forensic pathologists alike. None the previous attempts has so far succeeded establishing a single biomarker to reliably detect TBI with regards sensitivity: specificity ratio post mortem setting. This study investigated combination fluid biomarkers (obtained mortem), which may step towards increasing accuracy biochemical...
Biomechanical experiments help link tissue morphology with load-deformation characteristics. A tissue-dependent minimum sample number is indispensable to obtain accurate material properties. Stress-strain properties were retrieved from human dura mater and scalp skin, exemplifying two distinct soft tissues. Minimum sizes necessary for a stable estimation of obtained in simulation study. One-thousand random samples sequentially drawn calculating the point at which majority estimators settled...
The site-dependent load-deformation behavior of the human neurocranium and load dissipation within three-layered composite is not well understood. This study mechanically investigated 257 frontal, temporal, parietal occipital neurocranial bone samples at an age range 2 to 94 years, using three-point bending tests. Samples were tested as full-thickness composites, separated with both diploë attached removed. Right temporal thinnest all regions (median < 5 mm; p 0.001) withstood lowest failure...
The passive load-deformation properties of the human temporal muscle applicable to computer simulations head or comparison other graft materials are unexplored date and it is unclear, if these depend on age, sex, post-mortem interval body side. Eighty-eight fresh samples from 69 cadavers (age range 4 months – 94 years) were investigated in a quasi-static tensile setup. For comparative reasons, 20 age-matched fascia scalp tested same manner as muscle. Human showed an elastic modulus 1.58 ±...