A5005154607- Restraint-Related Deaths
- Traumatic Ocular and Foreign Body Injuries
- Autopsy Techniques and Outcomes
- Forensic Entomology and Diptera Studies
- Burn Injury Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Forensic Anthropology and Bioarchaeology Studies
- Child Abuse and Related Trauma
- Forensic and Genetic Research
- Injury Epidemiology and Prevention
- Criminal Law and Policy
- Medical and Health Sciences Research
- Nerve Injury and Rehabilitation
- Forensic Fingerprint Detection Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Climate Change and Health Impacts
- Thermoregulation and physiological responses
- Forensic Toxicology and Drug Analysis
- Neuroscience of respiration and sleep
- Pain Management and Treatment
- Medical Malpractice and Liability Issues
- Cerebrospinal fluid and hydrocephalus
- Poisoning and overdose treatments
- Pesticide Exposure and Toxicity
- Gun Ownership and Violence Research
University of Würzburg
2016-2025
University Medical Center Freiburg
2005-2011
University of Freiburg
1995-2010
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2003
Bellevue Hospital Center
2003
In-Q-Tel
2000
Blood-brain barrier (BBB) integrity is one of the important elements central nervous system (CNS) homeostasis. MicroRNAs (miRs) have been demonstrated to play a role in many CNS disorders such as stroke and traumatic brain injury. MiR-212/132 are highly expressed but their at BBB has not characterized yet. Thus, we analyzed expression miR-212/132 hypoxic mouse human microvascular endothelial cells (BMEC) well posttraumatic tissue serum exosomes. was detected capillaries by situ hybridization...
Abstract The aim of the present study was a refined analysis neuroinflammation including TMEM119 as useful microglia-specific marker in forensic assessments traumatic causes death, e.g., brain injury (TBI). Human tissue samples were obtained from autopsies and divided into cases with lethal TBI ( n = 25) subdivided three groups according to their trauma survival time compared an age-, gender-, postmortem interval-matched cohort sudden cardiovascular fatalities controls 23). Brain next cortex...
Abstract Aneurysmal subarachnoid hemorrhage (aSAH) is a debilitating condition with significant morbidity and mortality rates. Despite advancements in treatment, understanding the underlying pathophysiology, particularly inflammatory response, remains crucial for improving patient outcomes. In this study, we investigated presence of transmembrane protein 119 (TMEM119) microglial cells cerebrospinal fluid (CSF) as potential marker neuroinflammation following aSAH. CSF samples were collected...
Abstract Complete or incomplete decapitation as a consequence of suicidal hanging is very rare, few cases having been reported in the worldwide literature. Posthanging typically related to drop several meters. Three complete and one case by are with particular emphasis on internal findings vital reaction patterns. Personal, circumstantial, autopsy, toxicological data were analyzed define basic characteristics such extreme injuries. The crucial factor for state itself kinetic energy falling...
Abstract In the last few years, quantitative analysis of metabolites in body fluids using LC/MS has become an established method laboratory medicine and toxicology. By preparing metabolite profiles biological specimens, we are able to understand pathophysiological mechanisms at biochemical thus functional level. An innovative investigative method, which not yet been used widely forensic context, is use clinical application metabolomics. a metabolomic 41 samples postmortem cerebrospinal fluid...
The project "Latent Fingerprints and DNA on Human Skin" was the first systematic research in Europe dealing with detection of fingerprints left by offenders skin corpses. One thousand samples gave results that allow general statements materials methods used. tests were carried out according to a uniform trial structure. deposited natural donors latent treated magnetic powder or black fingerprint powder. Afterward, they lifted silicone casting material (Isomark(®)) gelatine foil. All lifts...
The aim of this study was to investigate if the biomarkers myelin basic protein (MBP) and neurofilament-H (NF-H) yielded informative value in forensic diagnostics when examining cadaveric cerebrospinal fluid (CSF) biochemically via an enzyme-linked immunosorbent assay (ELISA) comparing corresponding brain tissue fatal traumatic injury (TBI) autopsy cases by immunocytochemistry versus immunohistochemistry. In 21 trauma 19 control cases, CSF collected semi-sterile after suboccipital puncture...
Abstract Three food types were analyzed for the presence of Salmonella by AOAC culture method and International Organization Standardization (ISO 6579:2002) method. Paired test portions each type simultaneously both methods. A total 21 laboratories representing federal government agencies private industry, in United States Europe, participated this interlaboratory study. Foods artificially contaminated with competing microflora if naturally sources not available. No statistical differences...
Abstract Traumatic brain injury (TBI) is a ubiquitous, common sequela of accidents with an annual prevalence several million cases worldwide. In forensic pathology, structural proteins the cellular compartments CNS in serum and cerebrospinal fluid (CSF) have been predominantly used so far as markers acute trauma reaction for biochemical assessment neuropathological changes after TBI. The analysis endogenous metabolites offers innovative approach that has not yet considered widely causes...