A5051722803- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Neuropathies and Disorders
- Cancer Treatment and Pharmacology
- Peripheral Nerve Disorders
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Multiple Sclerosis Research Studies
- Cervical and Thoracic Myelopathy
- Myofascial pain diagnosis and treatment
- Education, Psychology, and Social Research
- Neurological Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Spinal Fractures and Fixation Techniques
- Genetic Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Dysphagia Assessment and Management
- Neurological and metabolic disorders
- Pain Management and Treatment
- Systemic Sclerosis and Related Diseases
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Cardiovascular Syncope and Autonomic Disorders
Masaryk University
2016-2025
University Hospital Brno
2015-2025
University Hospital in Motol
2024
College of Karlovy Vary
2023
Central European Institute of Technology
2013-2022
Central European Institute of Technology – Masaryk University
2012-2022
Neurology, Inc
2020
ERN EURO-NMD
2020
Weatherford College
2020
University Medical Center of the Johannes Gutenberg University Mainz
2019
In this prospective study, intraepidermal nerve fiber densities (IENFD) and subepidermal plexus (SENPD) were quantified by immunostaining in skin punch biopsies from the distal calf 99 patients with clinical symptoms of painful sensory neuropathy 37 age-matched healthy volunteers. The diagnosis was based on history abnormal thermal thresholds quantitative testing (QST). neuropathy, IENFD SENPD reduced to about 50% controls. Elevated warm detection QST correlated but not SENPD. Using...
Different sensory profiles in diabetic distal symmetrical sensory-motor polyneuropathy (DSPN) may be associated with pain and the responsiveness to analgesia. We aimed characterize phenotypes of patients painful painless neuropathy assess demographic, clinical, metabolic, electrophysiological parameters related presence neuropathic a large cohort well-defined DSPN subjects. This observational cross-sectional multi-center study (performed as part ncRNAPain EU consortium) 232 subjects...
Study Design Single-centre controlled pilot study. Objectives To evaluate the effect of prophylactic surgery and to review biases a therapeutic trial in asymptomatic degenerative cervical cord compression (ADCC) patients. Methods Patients with ADCC at least 1 predictor progression symptomatic myelopathy (DCM) were offered either or standard structured rehabilitation. Recruited patients clinically followed detect development DCM. Results Forty-one treated surgically 68 non-surgically...
Abstract Objectives To update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative compression ( NMDCCC ). Material and Methods A prospective observational follow‐up study was performed cohort 112 consecutive subjects (55 women 57 men; median age 59 years, range 40–79 years), either asymptomatic (40 subjects) or presenting with radiculopathy pain (72 subjects), who had completed at least 2 years (median duration 3 years)....
Abstract Aims To assess small‐fibre involvement in diabetic patients with neuropathic pain. Methods Peripheral nerve function was assessed 30 Type 2 diabetes mellitus (T2DM, n = 24) or impaired glucose tolerance (IGT, 6), and clinical symptoms of pain the feet, using conduction studies, autonomic tests, thermal quantitative sensory testing (T‐QST) quantification intra‐ subepidermal fibre densities skin punch biopsies. Results Clinical signs isolated were present 13 [pure neuropathy (pSFN)],...
Dysesthesias of the lower limbs are a common complaint patients and may be indicative peripheral neuropathy. Here we investigated prevalence type neuropathy in presenting with this compared diagnostic performance different modalities. Forty-two were recruited prospectively underwent clinical examination, nerve conduction studies, quantitative sensory testing (QST), skin biopsy at dorsum foot. All had correlate for their dysesthesias least one modality. Most (>90%) signs small fiber loss or...
The aim of this study was to investigate the characteristics prediabetes (preDM) and early (<3 years) diabetes mellitus type 2 (eDM2)-associated neuropathy value recently proposed diagnostic criteria for diabetic sensorimotor polyneuropathy (DSPN). A prospective case-control in a group 48 consecutive patients with eDM2, 16 preDM 40 age- sex-matched normoglycaemic controls performed. Clinical laboratory tests were used detect neuropathic abnormalities; these further classified terms recent...
Amyotrofická laterální skleróza (ALS) je závažné neurodegenerativní onemocnění, charakterizované progresivní ztrátou mozkových a/nebo míšních motoneuronů, klinicky se projevující progredujícími čistě motorickými parézami s výskytem fascikulací.Potíže začínají často monomelicky a postupně dochází k jejich šíření na ostatní končetiny, trupové svaly i bulbární.U části pacientů (cca 25 %) proces naopak primárně postihuje bulbární svalové skupiny projevuje iniciálně dysartrií dysfagií, následnou...
We pursued the hypothesis that complex regional pain syndrome (CRPS) signs observed by neurologic examination display a structure allowing for alignment of patients to particular phenotype clusters.Clinical data were obtained from 3 independent samples 444, 391, and 202 with CRPS. The among CRPS was analyzed in sample 1 validated 2 using hierarchical clustering. For 3, an individual score submitted k-means Pain characteristics, quantitative sensory testing, psychological tested this as...
Abstract Complex regional pain syndrome (CRPS) typically develops after fracture or trauma. Many of the studies so far have analyzed clinical and molecular markers CRPS in comparison with healthy controls. This approach, however, neglects mechanisms occurring during physiological trauma recovery. Therefore, we compared phenotype, sensory profiles, patient-reported outcomes, exosomal immunobarrier microRNAs (miRs) regulating barrier function immune response between controls (FCs) not...
Abstract The aim of this study was to evaluate the etiology in a group 84 patients with painful sensory neuropathy predominant small‐fiber dysfunction (54 men and 30 women, median: 58; range: 25–83 years) recruited from population South Moravian region Czech Republic. Involvement small nerve fibers verified by abnormal thermal thresholds and/or reduced intraepidermal fiber densities. Motor signs or symptoms significant clinical large‐fiber involvement were exclusionary; 33 patients, however,...
Abstract In this multicenter cross-sectional study, we determined sensory profiles of patients with (NL-1) and without neuropathic pain (NL-0) after nerve lesion assessed immune-related systemic gene expression. Patients matched healthy controls filled in questionnaires underwent neurological examination, neurophysiological studies, quantitative testing, blood withdrawal. Neuropathic was present 67/95 (71%) (NL-1). Tactile hyperalgesia the most prominent clinical sign NL-1 ( P < 0.05)....
Abstract The aim of this observational, cross-sectional study was to analyse lumbar magnetic resonance imaging (MRI) findings in patients with non-specific chronic low back pain (CLBP), and evaluate any correlation intensity their capacity predict neuropathic (NP) these patients. Fifty-two CLBP, between 21 62 years age, 50% men, were investigated. Lumbar MRI employed assess disc degeneration, endplate changes, Modic displacement, facet foraminal stenosis central spinal stenosis....
Non-myelopathic degenerative cervical spinal cord compression (NMDC) frequently occurs throughout aging and may progress to potentially irreversible myelopathy (DCM). Whereas standard clinical magnetic resonance imaging (MRI) electrophysiological measures assess severity neurological dysfunction, respectively, underlying microstructural deficits still have be established in NMDC DCM patients. The study aims establish tract-specific diffusion MRI markers of predict the progression...
Small-fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment pain care survivors.Eleven adult ischemic stroke patients a neurocritical unit were enrolled an observational cohort study. Intraepidermal nerve fiber density (IENFD) distal leg was assessed on admission to intensive 10-14 days later, together with electrophysiological testing.Of 11 recruited, 9 (82%) had sepsis or multiple-organ failure. Median IENFD (5.05 fibers/mm) decreased...
Abstract Aims This paper aims to investigate whether intraepidermal nerve‐fibre density ( IENFD ) may be used as a marker of the course neuropathy in patients with Type 2 diabetes mellitus. Methods Skin biopsies from distal leg were serially evaluated group 30 mellitus (median age 60 years, 17 men) short duration (< 3 years) and good glucose control, 23 age‐ sex‐matched controls. The time intervals between > years 33.8 months). Eighteen had symptoms or signs symmetrical diabetic...
Despite the high prevalence of depression and anxiety in chronic pain conditions, current knowledge concerning emotional distress among painful diabetic polyneuropathy (pDSPN) other diabetes mellitus (DM) sufferers is limited.
Assessment of neuropathic pain in chronic low back syndromes is important. However, there currently no gold standard for its diagnosis. The aim this observational cross-sectional study was to assess the component various using a range diagnostic tests.Included were 63 patients with axial (ALBP), 48 radicular (CRS) comprising 23 discogenic compression (CDRS) and 25 lumbar spinal stenosis (LSS), 74 controls. PainDETECT questionnaire (PDQ), quantitative sensory testing (QST), skin biopsy...
Abstract Complex regional pain syndrome (CRPS) develops after fracture. The acute CRPS phenotype resembles exaggerated inflammation, which is explained by local and systemic activation of a proinflammatory network including peptides cytokines. Epidemiologic data suggest that inactivation the peptidase angiotensin-converting enzyme in patients treated for hypertension increases odds to develop CRPS. This hint leads us investigate serum protease activity with vs respective controls. For this...