A5026972025- Myasthenia Gravis and Thymoma
- Cervical and Thoracic Myelopathy
- Genetic Neurodegenerative Diseases
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Parkinson's Disease and Spinal Disorders
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Skin Diseases and Diabetes
- Long-Term Effects of COVID-19
- Glaucoma and retinal disorders
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Antifungal resistance and susceptibility
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Inflammatory Myopathies and Dermatomyositis
- RNA modifications and cancer
- Immunodeficiency and Autoimmune Disorders
- Acute Lymphoblastic Leukemia research
- Polyomavirus and related diseases
- Pancreatitis Pathology and Treatment
- Wireless Sensor Networks for Data Analysis
- Adrenal Hormones and Disorders
University Hospital Brno
2018-2025
Masaryk University
2018-2025
Central European Institute of Technology
2020-2022
Central European Institute of Technology – Masaryk University
2020
Martin University Hospital
2009
Ocní klinika
2007
Myasthenia gravis (MG) patients could be a vulnerable group in the pandemic era of coronavirus 2019 (COVID-19) mainly due to respiratory muscle weakness, older age and long-term immunosuppressive treatment. We aimed define factors predicting severity COVID-19 MG risk exacerbation during COVID-19.We evaluated clinical features outcomes after 93 patients.Thirty-five (38%) had severe pneumonia we recorded 10 deaths (11%) COVID-19. Higher forced vital capacity (FVC) values tested before were...
Study Design Single-centre controlled pilot study. Objectives To evaluate the effect of prophylactic surgery and to review biases a therapeutic trial in asymptomatic degenerative cervical cord compression (ADCC) patients. Methods Patients with ADCC at least 1 predictor progression symptomatic myelopathy (DCM) were offered either or standard structured rehabilitation. Recruited patients clinically followed detect development DCM. Results Forty-one treated surgically 68 non-surgically...
Non-myelopathic degenerative cervical spinal cord compression (NMDC) frequently occurs throughout aging and may progress to potentially irreversible myelopathy (DCM). Whereas standard clinical magnetic resonance imaging (MRI) electrophysiological measures assess severity neurological dysfunction, respectively, underlying microstructural deficits still have be established in NMDC DCM patients. The study aims establish tract-specific diffusion MRI markers of predict the progression...
Abstract Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability detect microstructural myelopathy NMDCCC patients. In 7 young healthy volunteers, 13 age-comparable controls, 18 mild 15 severe NMDCCC, provided higher signal-to-noise ratio, enhanced...
Despite the high prevalence of depression and anxiety in chronic pain conditions, current knowledge concerning emotional distress among painful diabetic polyneuropathy (pDSPN) other diabetes mellitus (DM) sufferers is limited.
Degenerative cervical spinal cord compression is becoming increasingly prevalent, yet the MRI criteria that define are vague, and vary between studies. This contribution addresses detection of by means Spinal Cord Toolbox (SCT) assesses variability morphometric parameters extracted with it.Prospective cross-sectional study. Two types examination, 3 1.5 T, were performed on 66 healthy controls 118 participants compression. Morphometric from 3T obtained (cross-sectional area, solidity,...
Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative spinal cord (CSC) compression. The non-myelopathic stage compression (NMDC) highly prevalent and often progresses to disabling DCM. This study aims disclose markers progressive neurochemical alterations in NMDC DCM by utilizing an approach based on state-of-the-art proton magnetic resonance spectroscopy (1H-MRS). Proton-MRS data were prospectively acquired from 73 participants with CSC 47 healthy controls (HCs)....
Background and aims: The thiopurine drugs, azathioprine (AZA) 6-mercaptopurine, are established in the treatment of infl ammatory bowel diseases (IBD).Polymorphisms S-methyltransferase (TPMT) gene have been associated with adverse drug reactions (ADRs) to AZA.Methods: aim this study was evaluate TPMT polymorphisms AZA-related toxicity a Slovak cohort 220 IBD patients treated AZA.In every patient, dose duration AZA therapy, concomitant 5-aminosalicylate (5-ASA) medication, frequency, type,...
Degenerative cervical myelopathy (DCM) represents the final consequence of a series degenerative changes in spine, resulting spinal canal stenosis and mechanical stress on cord. This process leads to subsequent pathophysiological processes cord tissues. The primary mechanism injury is compression cord, detectable by magnetic resonance imaging (MRI), serving as hallmark for diagnosing DCM. However, relative resilience clinical-radiological discordance, i.e., some individuals may exhibit MRI...
The main goal of this study was to describe the Czech population patients with MG in terms demographics, disease characteristics, management approaches, and treatment trends. We selected all patients, both incident prevalent, who were enrolled MyReg registry between August 24, 2015 November 19, 2021. For descriptive analysis, registry, regardless their date diagnosis or enrolment, included. analyzed following disease-related endpoints: myasthenia gravis composite (MGC) score, forced vital...
ABSTRACT Introduction : The objective of this study was to develop a simple method for quantitative assessment myotonia in patients with myotonic dystrophy type 1 (DM1) and DM2, compare the severity, correlate outcome subjective scale, Myotonia Behaviour Scale (MBS). Methods A commercially available dynamometer used all measurements. relaxation time after voluntary contraction measured 20 DM1, 25 35 healthy controls. Results average 0.17 s controls, 2.96 0.4 DM2. correlation between MBS...
Thiopurine S-methyltransferase (TPMT) plays an important role in the metabolism of thiopurines. It has been suggested that TPMT genetic polymorphisms lead to dose-related hematopoietic toxicity. Since there are major ethnic differences prevalence particular variants, it is for each country study their own order estimate variants-related thiopurines toxicity population suffering from inflammatory bowel disease (IBD).The aim this was determine frequency four most common allelic variants gene...
Spinal muscular atrophy (SMA) is a genetic disorder that causes progressive degeneration of lower motor neurons and the subsequent loss muscle function throughout body. It second most common recessive in individuals European descent present all populations. Accurate tools exist for diagnosing SMA from genome sequencing data. However, there are no publicly available GRCh38-aligned data panel or exome assays which continue to be used as first line tests neuromuscular disorders. This deficiency...
Využití škál a hodnocení pacientů v rutinní klinické praxi není příliš oblíbené, přesto má škálování nezastupitelné místo, protože nám ukazuje vývoj choroby čase, pomáhá hodnotit efektivitu léčby umožňuje srovnání skupin mezi sebou.Skóre využívaná myastenii i jejich však mají určitá specifika
Aim: Existing epidemiological studies of myasthenia feature differences in incidence, prevalence, age-and gender-specific incidences, mortality rate, and even the prevalence subtypes. The aim this study was to compare over all management patients with myasthenia, severity disease, a number clinical laboratory characteristics therapy approaches amongst Czech Republic Slovak Republic. Patients methods: Data were retrospectively collected from two registries (Brno) (Bratislava). randomly...