A5077246003- Inflammatory Bowel Disease
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Microscopic Colitis
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Glioma Diagnosis and Treatment
- Medical Image Segmentation Techniques
- Smoking Behavior and Cessation
- Immunodeficiency and Autoimmune Disorders
- Medical Imaging Techniques and Applications
- Anatomy and Medical Technology
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Eosinophilic Esophagitis
- Surgical Simulation and Training
- Venous Thromboembolism Diagnosis and Management
- Advanced Neuroimaging Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Biosimilars and Bioanalytical Methods
- Neurosurgical Procedures and Complications
- Neuroscience and Neural Engineering
- Electrical and Bioimpedance Tomography
- Helicobacter pylori-related gastroenterology studies
Leipzig University
2012-2025
University Hospital Leipzig
2015-2024
Klinik und Poliklinik für Neurologie
2005-2024
Takeda (Switzerland)
2019-2024
Takeda (United States)
2023-2024
Takeda (France)
2023
University Medical Center
2022
Leipzig University of Applied Sciences
2020
Institute for Bioprocessing and Analytical Measurement Techniques
2020
Technische Universität Ilmenau
2020
Approximately half the patients with ulcerative colitis who undergo restorative proctocolectomy ileal pouch-anal anastomosis (IPAA) will subsequently have pouchitis, and among those patients, one fifth chronic pouchitis. We conducted a phase 4, double-blind, randomized trial to evaluate vedolizumab in adult whom pouchitis had developed after undergoing IPAA for colitis. Patients were assigned (in 1:1 ratio) receive intravenously at dose of 300 mg or placebo on day 1 weeks 2, 6, 14, 22, 30....
Gastro-oesophageal reflux disease (GERD) can be associated with a variety of extra-oesophageal disorders (EED) such as chronic cough, asthma, laryngeal disorder or chest pain. The aim the study was to estimate and compare prevalence EED in population symptomatic GERD presenting either erosive (ERD) non-erosive (NERD).Baseline data were collected from prospective, multicentre, open cohort (ProGERD) which patients will followed for 5 years after initial treatment esomeprazole. Within framework...
OBJECTIVE Cranioplasty is routinely performed in neurosurgery. One of its underestimated problems the high postoperative complication rate up to 40%. Due lack good prospective studies and small number patients (5-20 each year) who receive alloplastic materials, decisions favor or against a certain material are based on subjective empirical economic reasons. The main goal this study-the first prospective, randomized multicenter study Germany-of custom-made titanium hydroxyapatite (HA)...
Darvadstrocel is an expanded allogeneic adipose-derived mesenchymal stem cell therapy for the treatment of complex perianal fistulas in patients with Crohn's disease. Safety and efficacy outcomes from clinical trial known as "Adipose derived cells induction remission fistulizing disease," or ADMIRE-CD (NCT01541579), up to 52 weeks posttreatment were previously reported. Here, extended 104-week follow-up are reported.The goal this study was assess long-term safety darvadstrocel at 2 years...
Abstract Background Due to the lack of high-quality evidence which has hindered development evidence-based guidelines, there is a need provide general guidance on cranioplasty (CP) following traumatic brain injury (TBI), as well identify areas ongoing uncertainty via consensus-based approach. Methods The international consensus meeting post-traumatic CP was held during International Conference Recent Advances in Neurotraumatology (ICRAN), Naples, Italy, June 2018. This endorsed by...
Flow diversion (FD) has emerged as superior minimally invasive therapy for cerebral aneurysms. However, aneurysms of small peripheral vessel segments have not yet been adequately treatable. More specifically, currently established devices necessitate large microcatheters which impede atraumatic maneuvering. The Silk Vista Baby (SVB), a novel flow diverter, offers the unique feature deliverability via 0.017 inch microcatheter. This study reports our first experience with SVB in challenging...
Intraoperative 3D ultrasound (3D-iUS) may enhance the quality of neuronavigation by adding information about brain shift and tumor remnants. The aim our study was to prove concept on basis technical human effects. A 3D-ultrasound navigation system consisting a standard personal computer containing video grabber card in combination with an optical tracking (NDI Polaris) device (Siemens Omnia) 7.5 MHz probe used. 3D-iUS datasets were acquired after craniotomy, at different subsequent times...
This presentation is a study of 153 patients with complete carotid artery occlusion proved by angiography. We have made an effort to evaluate their clinical course from onset symptoms through 4-year follow-up, hoping shed light on the future people afflicted this disease. The great variation in picture it difficult classify types cases. Two overlapping categories were finally accepted. First, grouped as type symptoms. group included those having sudden, episodic, or progressive onset, well...
I N 1958 we first reported on our experiences in the use of sodium diatrizoate (Hypaque) for cerebral angiography. 3 At that time were particularly interested comparing morbidity and mortali ty among patients studied angiographically from standpoint contrast material was used examination. Of various media available, selected because results obtained animal experimentation. All present study investigated by Hypaque The purpose this report is not only to suInmarize effectiveness diatrizoatc as...
Between September, 1948, and January, 1958, we have encountered by angiographic studies 50 patients with nonfilling or thread-like filling of the proximal portion one anterior cerebral artery (in 1 case bilateral) associated neurologic and/or psychiatric (dementia, impaired insight, anxiety, loss initiative, mentation) signs symptoms. Stenosis occlusion has been seen in about 11% who either are admitted a diagnosis "stroke" proved to cerebrovascular disease before discharge from hospital. A...
Summary Background ERELATE was a phase 4, multinational, retrospective, observational study. Aim To evaluate the relationship between intravenous vedolizumab exposure and treatment outcomes over 52 weeks in adults with ulcerative colitis (UC) or Crohn’s disease (CD). Methods Real‐world data from patients UC CD treated nine centres six countries were collected retrospectively. Treatment at Weeks 14, 26 52. An established population pharmacokinetic model (incorporating observed concentrations...
Planning cranioplasty (CPL) in patients with suspected or proven post-traumatic hydrocephalus (PTH) poses a significant management challenge due to lack of clear guidance. This project aims create European document improve adherence and adapt local protocols based on available resources national health systems. After thorough non-systematic review, steering committee (SC) formed expert panel (EP) for two-round questionnaire using the Delphi method. The employed 9-point Likert scale assess...
Vedolizumab is indicated for the treatment of chronic pouchitis in European Union. We assessed whether vedolizumab induced mucosal healing (MH) and if MH was associated with clinical improvements.
Introduction Venous thromboembolic events (VTEs) like deep vein thrombosis or pulmonary embolism are frequent complications in (neuro) critical ill patients. Anticoagulation for VTE after space-occupying brain infarction is a therapeutic dilemma. The aim of this retrospective study was to investigate the frequency clinically apparent patients with acute ischaemic stroke (AIS) due large vessel occlusion (LVO), its treatment, and rate complications. Methods Patients first AIS LVO were assigned...
This randomized, open-label, ambulatory, controlled clinical study investigated biomarkers associated with cardiovascular risk and of exposure to 10 selected harmful potentially constituents (HPHC) in cigarette smoke 316 male female Polish smokers. Subjects were randomized continue smoking conventional cigarettes (CC; N=79) or switch the Electrically Heated Cigarette Smoking System series-K (EHCSS-K6; N=237). Biomarker assessments performed at several time points during baseline 1-month...
Sometimes cranioplasty is necessary to reconstruct skull bone defects after a neurosurgical operation. If an autologous unavailable, alloplastic materials are used. The standard technical approach for the fabrication of cranial implants based on 3D imaging by computed tomography using defect and contralateral site. A new uses surface scans, which accurately replicate curvature removed flap. For this purpose, flap scanned intraoperatively digitized accordingly. When design procedure developed...
A randomized, controlled, open-label, parallel-group, single-center study to determine biomarkers of exposure nine selected harmful and potentially constituents (HPHC) in cigarette smoke urinary excretion mutagenic material 160 male female subjects smoking Marlboro cigarettes (6 mg tar, 0.5mg nicotine, 7.0mg CO) at baseline. Subjects were randomized continue cigarettes, or switch using an Electrically Heated Cigarette Smoking System (EHCSS) one two EHCSS series-K the EHCSS-K6 (5mg 0.3mg 0.6...