A5072887736- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Immunotherapy and Immune Responses
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- Sepsis Diagnosis and Treatment
- T-cell and B-cell Immunology
- Multiple Sclerosis Research Studies
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Immune Response and Inflammation
- Reproductive System and Pregnancy
- Intensive Care Unit Cognitive Disorders
- Music Therapy and Health
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Immune cells in cancer
- Acute Ischemic Stroke Management
- Pregnancy and Medication Impact
- Cytokine Signaling Pathways and Interactions
- Tryptophan and brain disorders
- Cardiovascular Function and Risk Factors
- Neonatal and fetal brain pathology
- Clinical Nutrition and Gastroenterology
- Child Abuse and Related Trauma
Universität Hamburg
2019-2025
University Medical Center Hamburg-Eppendorf
2019-2025
Klinik und Poliklinik für Neurologie
2021
Universitätsmedizin Göttingen
2019
Martini-Klinik
2019
University of Göttingen
2011-2017
Hertie Foundation
2011-2013
Glucocorticoids (GCs) are widely used to treat acute relapses of multiple sclerosis (MS). In this study, we demonstrate that liposomal encapsulation augments the therapeutic potency GCs as they ameliorate experimental autoimmune encephalomyelitis (EAE) same extent free GC, but at strongly reduced dosage and application frequency. Importantly, is accompanied by an altered mode action. Unlike GCs, which mainly target T lymphocytes during EAE therapy, only marginally affect cell apoptosis...
The evolution of intracranial pressure (ICP) critically ill patients admitted to a neurointensive care unit (ICU) is difficult predict. Besides the underlying disease and compromised space, ICP affected by multitude factors, many which are monitored on ICU, but complexity resulting patterns limits their clinical use. This paves way for new machine learning techniques assist management undergoing invasive monitoring independent disease. An institutional cohort (ICP-ICU) with (n = 1346) was...
In patients with traumatic brain injury (TBI), adequate oxygenation is crucial to optimize survival and neurological outcome. However, supranormal oxygen partial pressure (PaO2) only leads minor increase in cerebral delivery but can cause numerous pathophysiological disturbances. Therefore, we aimed study effects of hyperoxia on patient outcome identify optimum PaO2 ranges. This retrospective, single-center cohort included TBI receiving mechanical ventilation for ≥ 72 h. Time-weighted mean...
Myeloid cells play an important role in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Monocytes, macrophages, microglia can adopt two distinct phenotypes, with M1-polarized being more related to inflammation autoimmunity while M2-polarized contribute tissue repair anti-inflammatory processes. Here, we show that deletion mineralocorticoid receptor (MR) bone marrow-derived macrophages peritoneal caused their polarization...
Abstract Aneurysmal subarachnoid haemorrhage (aSAH) can lead to complications such as acute hydrocephalic congestion. Treatment of this condition often includes establishing an external ventricular drainage (EVD). However, chronic hydrocephalus develops in some patients, who then require placement a permanent ventriculoperitoneal (VP) shunt. The aim study was employ recurrent neural network (RNN)-based machine learning techniques identify patients VP shunt at early stage. This retrospective...
Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research paradigm to explore dynamics of immune repertoire changes active and inactive disease. Here, we characterize immunomodulation at the single-clone level by sequencing in healthy women female MS patients over course pregnancy. Clonality is significantly...
Terson syndrome (TS), an intraocular hemorrhage associated with aneurysmal subarachnoid (aSAH), occurs in up to 46% of all patients hemorrhage. Despite its high incidence, TS is underrepresented the literature, and aSAH are sometimes not systematically evaluated for presence clinical practice. This work aims raise awareness TS, reevaluate previous scientific findings, describe risk factors occurrence present our local diagnostic treatment concept.All treated at institution between October...
Acute and chronic hydrocephalus are common pathologies after aneurysmal subarachnoid hemorrhage (SAH). Generally, the presence of acute is associated with elevated intracranial pressure (ICP) treated a ventricular drain. Subsequently, however, pronounced without ICP may develop in some patients SAH postacute phase. This described as low-pressure (aLPH), there very limited data literature this pathology. The aim study was to evaluate rate factors aLPH describe its clinical course.In...
This study aimed to investigate if pre-existing neurological conditions, such as dementia and a history of cerebrovascular disease, increase the risk severe outcomes including death, intensive care unit (ICU) admission vascular events in patients hospitalized with acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection 2022, when Omicron was predominant variant.A retrospective analysis conducted all SARS-CoV-2 infection, confirmed by polymerase chain reaction test, admitted...
The biomarker N-terminal pro B-type natriuretic peptide (NT-proBNP) has predictive value for identifying individuals at risk cardiovascular disease (CVD). However, it is not widely used screening in the general population, potentially due to financial and operational reasons. This study aims develop a deep-learning model as an efficient means reliably identify CVD by predicting serum levels of NT-proBNP from ECG.
Unpredictable vegetative deteriorations made the treatment of patients with acute COVID-19 on intensive care unit particularly challenging during first waves pandemic. Clinical correlates dysautonomia and their impact disease course in critically ill are unknown.
Objective: Several guidelines recommend oral administration of nimodipine as vasospasm prophylaxis after aneurysmal subarachnoid hemorrhage (SAH). However, in clinical practice, the drug is administered orally and intravenously (i.v.), depending on conditions local treatment regimens. We have therefore investigated safety effects switching from i.v. to therapy. Methods: Patients with SAH between January 2014 April 2018 initial therapy, which was subsequently switched administration, were...
Introduction: Endovascular thrombectomy stands as a pivotal component in the standard care for patients experiencing acute ischemic stroke with large vessel occlusion. Subsequent often extends to neurological intensive unit. While fluid management is integral care, association between early balance and functional outcomes post-thrombectomy has not yet been thoroughly investigated. Methods: In retrospective analysis of an observational, single-center study spanning from 2015 2021 at...
Background: Energy expenditure (EE) in patients with aneurysmal subarachnoid hemorrhage (SAH) may differ from other intracranial pathologies, such as intracerebral (ICH) or traumatic brain injury (TBI), due to an activation of the sympathetic nervous system. Indirect calorimetry (IC) is recommended, but not always available. We study EE, catabolism, and metabolic stress SAH, TBI, ICH, sepsis controls. Methods: A prospective observational was conducted intensive care units University Medical...