A5102739566- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Action Observation and Synchronization
- Neural dynamics and brain function
- Acute Ischemic Stroke Management
- Motor Control and Adaptation
- Advanced Neuroimaging Techniques and Applications
- Muscle activation and electromyography studies
- Neurological disorders and treatments
- Optical Imaging and Spectroscopy Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Transcranial Magnetic Stimulation Studies
- Psychosomatic Disorders and Their Treatments
- Advanced MRI Techniques and Applications
- Visual perception and processing mechanisms
- Child Abuse and Trauma
- Stroke Rehabilitation and Recovery
- Hemispheric Asymmetry in Neuroscience
- Diet and metabolism studies
- Autism Spectrum Disorder Research
- Venous Thromboembolism Diagnosis and Management
- Infant Development and Preterm Care
- Spatial Cognition and Navigation
- Neurobiology of Language and Bilingualism
- Biomedical and Chemical Research
University Medical Center Hamburg-Eppendorf
2008-2025
Universität Hamburg
2008-2025
Klinik und Poliklinik für Neurologie
2019-2025
RWTH Aachen University
2018-2024
Jülich Aachen Research Alliance
2018-2024
Forschungszentrum Jülich
2022-2024
University of Cambridge
2023-2024
Universitätsmedizin Göttingen
2024
Brain (Germany)
2018-2022
Charité - Universitätsmedizin Berlin
2021
Bimanual co-ordination of skilled finger movements is a high-level capability the human motor system and virtually always requires training. Little known about physiological processes underlying successful bimanual performance skill acquisition. In present study, we used task-related coherence (TRCoh) power (TRPow) analysis multichannel surface EEG to investigate functional coupling regional activation sensorimotor regions during We focused on changes in interhemispheric associated with...
Brain-to-brain synchrony has been proposed as an important mechanism underlying social interaction. While first findings indicate that it may be modulated in children with autism spectrum disorder (ASD), no study to date investigated the influence of different interaction partners and task characteristics. Using functional near-infrared spectroscopy hyperscanning, we assessed brain-to-brain 41 male typically developing (TD) (8-18 years; control sample), well 18 ASD age-matched TD (matched...
Endovascular therapy is the standard of care in treatment acute ischemic stroke due to large-vessel occlusion. Often, more than one retrieval attempt needed achieve reperfusion. We aimed quantify influence endovascular on clinical outcome depending number retrievals for successful reperfusion a large multi-center cohort. For this observational cohort study, 2611 patients from prospective German Stroke Registry included between June 2015 and April 2018 were analyzed. Patients who received...
Hyperscanning studies have begun to unravel the brain mechanisms underlying social interaction, indicating a functional role for interpersonal neural synchronization (INS), yet that drive INS are poorly understood. The current study, thus, addresses whether is functionally-distinct from synchrony in other systems - specifically autonomic nervous system and motor behavior. To test this, we used concurrent near-infrared spectroscopy electrocardiography recordings, while N = 34 mother-child...
Age-related cortical atrophy, approximated by thickness measurements from magnetic resonance imaging, follows a characteristic pattern over the lifespan. Although its determinants remain unknown, mounting evidence demonstrates correspondence between connectivity profiles of structural and functional brain networks atrophy in health neurological disease. Here, we performed cross-sectional multimodal neuroimaging analysis 2633 individuals large population-based cohort to characterize...
The effects of imaging-based intravenous thrombolysis on outcomes based patient sex remain unclear. We aimed to investigate whether among patients with stroke an unknown onset time and treated are influenced by their sex.
Introduction: Previous studies have shown the efficacy and safety of time-based intravenous thrombolysis (IVT) in elderly patients with ischemic stroke. However, there are concerns about bleeding associated IVT due to their low body weight, renal dysfunction, concomitant use antithrombotic drugs. Robust evidence on effect IVT, particularly unknown onset stroke, is limited. This study aimed evaluate imaging-based this population. Methods: Patients an stroke were evaluated using individual...
We characterized reflexes of the upper limb elicited by electrical stimulation fingers. Surface electromyogram (EMG) was recorded from several extremity muscles, and a finger stimulated through paired ring electrodes. A train 4–10 shocks at frequency 300 Hz an intensity 4–6 times perceptual threshold most effective stimulus for evoking EMG activity in relaxed arm muscles. Habituation prominent. Latencies were <100 ms proximal forearm least 40 prior to voluntary withdrawal movements. The...
Analyses of alterations brain networks have gained an increasing interest in stroke rehabilitation research. Compared with functional derived from resting-state analyses, there is limited knowledge how structural network topology might undergo changes after and, more importantly, if information obtained early could enhance recovery models to infer later outcomes. The present work re-analysed cross-sectional imaging data, within the first 2 weeks, 45 acute patients (22 females, 24 right-sided...
Concurrent brain recordings of two or more interacting persons, an approach termed hyperscanning, are gaining increasing importance for our understanding the neurobiological underpinnings social interactions, and possibly interpersonal relationships. Functional near-infrared spectroscopy (fNIRS) is well suited conducting hyperscanning experiments because it measures local hemodynamic effects with a high sampling rate and, importantly, can be applied in natural settings, not requiring strict...
Abstract Elucidating the neural basis of social behavior is a long‐standing challenge in neuroscience. Such endeavors are driven by attempts to extend isolated perspective on human brain considering interacting persons' activities, but theoretical and computational framework for this purpose still its infancy. Here, we posit comprehensive based bipartite graphs interbrain networks address whether they provide meaningful insights into underpinnings interactions. First, show that nodal density...
Movement-related cerebellar activation may be due to sensory or motor processing. Ordinarily, and processing are obligatorily linked, but in patients who have severe pansensory neuropathies with normal muscle strength, activity occurs isolation. In the present study, positron emission tomography functional magnetic resonance imaging such showed no passive movement, whereas there was prominent movement-related despite absence of proprioceptive visual input. The results indicate that within...
Concurrent brain recordings of two or more interacting persons, an approach termed hyperscanning, are gaining increasing importance for our understanding the neurobiological underpinnings social interactions, and possibly interpersonal relationships. Functional near-infrared spectroscopy (fNIRS) is well suited conducting hyperscanning experiments because it measures local hemodynamic effects with a high sampling rate and, importantly, can be applied in natural settings, not requiring strict...
Background Early adversity is believed to alter the body’s stress‐response systems, putting children at increased risk for somatic and mental health problems. However, it remains unclear whether such alterations normalize under improved caregiving experiences. Thus, goal of present study was investigate (a) in foster care show endocrine immunological relative living with their biological families, (b) these change over time spent family, (c) are modulated by current Methods A total 94 157...
The current review provides an overview of various techniques for manipulating interpersonal neural synchrony. It presents a 'second-person' neuroscience approach as potential clinical tool treating certain mental disorders characterized by social interaction challenges, including Autism Spectrum Disorder, Attachment and Social Anxiety Disorder.
Abstract Hyperscanning studies have begun to unravel the brain mechanisms underlying social interaction, indicating a functional role for interpersonal neural synchronization (INS), yet that drive INS are poorly understood. While synchrony is considered multimodal phenomenon, it not clear how different biological and behavioral markers related each other. The current study, thus, addresses whether functionally-distinct from in other systems – specifically autonomic nervous system (ANS) motor...
Abstract Humans synchronize with one another to foster successful interactions. Here, we use a multimodal data fusion approach the aim of elucidating neurobiological mechanisms by which interpersonal neural synchronization (INS) occurs. Our meta-analysis 22 functional magnetic resonance imaging and 69 near-infrared spectroscopy hyperscanning experiments (740 3,721 subjects) revealed robust brain-regional correlates INS in right temporoparietal junction left ventral prefrontal cortex....
Abstract Background Endovascular treatment (ET) options for acute stroke due to distal middle cerebral artery occlusions are rapidly evolving, but data on outcome and safety sparse. We therefore performed an analysis of patients undergoing ET primary M3 in routine clinical practice a nationwide registry. Methods Patients enrolled between 01/20 12/21 the prospective, multicenter German Stroke Registry-Endovascular Treatment (GSR-ET) were screened mechanical thrombectomy occlusion. analyzed...
Introduction: Endovascular thrombectomy stands as a pivotal component in the standard care for patients experiencing acute ischemic stroke with large vessel occlusion. Subsequent often extends to neurological intensive unit. While fluid management is integral care, association between early balance and functional outcomes post-thrombectomy has not yet been thoroughly investigated. Methods: In retrospective analysis of an observational, single-center study spanning from 2015 2021 at...