A5042011750- Intracranial Aneurysms: Treatment and Complications
- Moyamoya disease diagnosis and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Neurological Complications and Syndromes
- Facial Nerve Paralysis Treatment and Research
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Peripheral Nerve Disorders
- Nerve Injury and Rehabilitation
- Cardiovascular and Diving-Related Complications
- Advanced MRI Techniques and Applications
- Vestibular and auditory disorders
- Botulinum Toxin and Related Neurological Disorders
- Orthopedic Surgery and Rehabilitation
- Meningioma and schwannoma management
- Olfactory and Sensory Function Studies
- Craniofacial Disorders and Treatments
- Trigeminal Neuralgia and Treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Pain Mechanisms and Treatments
- Neonatal Respiratory Health Research
- Aortic Disease and Treatment Approaches
- Neurosurgical Procedures and Complications
University of Tübingen
2019-2024
Universitätsklinikum Tübingen
2023
University Children's Hospital Tübingen
2019-2022
Innsbruck Medical University
2015-2017
BACKGROUND AND OBJECTIVES: The underlying pathophysiological cause of moyamoya angiopathy (MMA) is still unclear. High-resolution vessel wall imaging has become a useful tool. aim was to study contrast-enhancement (VW-CE) as an marker predict disease progression in MMA. METHODS: Patients with MMA, who had undergone serial contrast-enhanced high-resolution MRI concomitant and follow-up digital subtraction angiography, were analyzed retrospectively. VW-CE semiquantified by measurement the...
Rationale: Aneurysmal subarachnoid hemorrhage (SAH) has high morbidity and mortality. While the primary injury results from initial bleeding cannot currently be influenced, secondary through vasospasm delayed cerebral ischemia worsens outcome might a target for interventions to improve outcome. To date, beside aneurysm treatment prevent re-bleeding administration of oral nimodipine, there is no therapy available, so novel concepts are needed. Evidence suggests that inflammation contributes...
BACKGROUND AND OBJECTIVES: Patients with Moyamoya disease (MMD) have an above-average incidence of neuropsychological impairment and psychiatric comorbidities such as depression. Prevalence correlation preoperative imaging findings were identified in previous studies, a reduced health-related quality life (HRQOL) has been shown. This study investigates changes performance HRQOL after revascularization. METHODS: Thirty-two adult patients MMD (23 female, 9 male; mean age 39.1 year ±14.7)...
Abstract Background and Purpose This study explores the use of deep learning (DL) techniques in MRI orbit to enhance imaging. Standard protocols, although detailed, have lengthy acquisition times. We investigate DL‐based methods for T2‐weighted T1‐weighted, fat‐saturated, contrast‐enhanced turbo spin echo (TSE) sequences, aiming improve image quality, reduce time, minimize artifacts, diagnostic confidence orbital Methods In a 3‐Tesla 50 patients evaluating diseases from March July 2023,...
Abstract Moyamoya disease (MMD) is a rare stenoocclusive cerebral vasculopathy often treated by neurosurgical revascularization using extracranial-intracranial bypasses to prevent ischemic or hemorrhagic events. Little known about the vascular risk profile of adult MMD patients compared general population. We therefore analyzed 133 and them with data from more than 22,000 German Health Update database. Patients showed an age- sex-adjusted increased prevalence arterial hypertension,...
Severe malaria may influence inner ear function, although this possibility has not been examined prospectively. In a retrospective analysis, hearing impairment was found in 9 of 23 patients with cerebral malaria. An objective method to quickly evaluate the function are otoacoustic emissions. Negative transient emissions associated threshold shift 20 dB and above. This prospective multicenter study analyses severe up age 10 years. three sites (Ghana, Gabon, Kenya) 144 108 control children...
OBJECTIVE The overall benefit of employing a sitting/semisitting position for neurosurgical procedures remains under criticism due to concerns additional risk, especially the risk intraoperative venous air embolism (VAE). aim this single-center cohort study was evaluate frequency and severity VAEs associated complications in patients undergoing neurosurgery lounging position. METHODS From 2010 2020, 1000 patients, including 172 with patent foramen ovale, underwent surgery different...
In diffusion MRI, the advent of high angular resolution imaging (HARDI) and HARDI with compressed sensing (HARDI+CS) has led to clinically practical signal acquisition techniques which allow for assessment white matter architecture in routine patient studies. However, reconstruction visualization fiber pathways by tractography not yet been established as a standard methodology can easily be applied. This is due various algorithmic problems, such lack robustness, error propagation necessity...
<b><i>Background and Purpose:</i></b> Hemodynamic evaluation of moyamoya patients is crucial to decide the treatment strategy. Recently, CO<sub>2</sub>-triggered BOLD MRI has been shown be a promising tool for hemodynamic patients. However, longitudinal reliability this technique in follow-up examinations unknown. This study aims analyze data prove long-term control <b><i>Methods:</i></b> Longitudinal CO<sub>2</sub> with...
Moyamoya angiopathy (MMA) related cerebral perfusion deficits or infarctions might influence quality of life (QoL). This study examines preoperative QoL in adult patients with MMA and correlates these findings obtained via diagnostic imaging. Sixty-seven underwent neuropsychological testing including questionnaires to determine QoL, as well psychiatric depressive symptoms. The results were checked for correlation territorial hypoperfusions seen H215O PET acetazolamide (ACZ) challenge...
Abstract Objective To evaluate hearing loss in children as a complication of sickle‐cell disease. Methods In Kumasi, Ghana, 35 with SCD aged 6 months to 10 years underwent transient‐evoked otoacoustic emissions testing ( TEOAE ) investigate the function inner ear. Healthy Ghanaian recruited school and kindergarten served controls. Results One 13 115 control failed testing. This difference between group was not statistically significant. Conclusion Early impairment does regularly occur...
BACKGROUND AND OBJECTIVE: Although an increased intracranial pressure (ICP) is a known problem in children with syndromic craniosynostosis, it remains unclear whether elevated ICP and impaired cerebral perfusion exist nonsyndromic synostosis should be defined as targets of primary treatment. This study aimed to investigate ICP, autoregulation (CAR), brain infants craniosynostosis at first surgical intervention. METHODS: Forty-three were prospectively included. The patients underwent...
Background Neoplastic lesions affecting peripheral nerves are rare in the general population and, most often, benign nerve sheath tumors. However, a minority of represent high-grade malignancies associated with poor prognosis, such as malignant tumors (MPNSTs). Very rarely, these non-nerve (PNNSTs), hematological neoplasms that impair function. These can be hard to distinguish from MPNSTs and other arising itself. In present case report, we describe direct infiltration by tumor cells...
Summary: A 71-year-old man who had hip abductor insufficiency due to a chronic injury the right superior gluteal nerve after lipoma resection presented our outpatient clinic 1.5 years postoperatively with persistent pain, atrophy of gluteus medius muscle, and Trendelenburg sign corresponding limp. magnetic resonance imaging scan neurophysiological diagnostics confirmed lesion completed reinnervation absent pathological spontaneous activity, excluding neurosurgical options restore abduction....
Background Facial palsy after vestibular schwannoma surgery is temporary in many cases but can significantly affect patients’ quality of life. Physical training—initially guided and subsequently performed by the patient—is paramount importance for recovery facial nerve function. The introduction medical application software (apps) might improve therapy maintaining motivation daily home-based training surveilling rehabilitation progress. Methods We developed a mobile app, “FACEsemper”,...
To determine the area most at risk of delayed cerebral ischemia (DCI) in relation to location ruptured aneurysm patients with aneurysmal subarachnoid hemorrhage (aSAH) and, therefore, help choose site for focal multimodal neuromonitoring.We retrospectively analyzed angiographic findings, CCT scans, and patient charts who were admitted aSAH our neurosurgical intensive care unit between 2009 2017. DCI was defined as infarction on 2-6 weeks after aSAH.DCI occurred 17.9% out 357 included...
This study aimed to analyze the possibility of artifact reduction using a new iterative metal algorithm (iMAR) in diagnosis perfusion deficits due vasospasms and evaluate its clinical relevance.Sixty-one volume computed tomographies 24 patients after coiling or aneurysm clipping were reconstructed standard-filtered back-projection iMAR retrospectively. The degree artifacts was evaluated as well size nonevaluable area. Diagnostic performance compared with digital subtraction...
Objective: To evaluate the clinical value of early post-operative computed tomographic angiography (CTA) after direct extracranial-intracranial (EC-IC) bypass surgery in moyamoya patients. Methods: A retrospective analysis all adult patients treated at our center from 2013 to 2019 with a EC-IC was performed. Early CTA (within 24 h surgery) compared conventional digital subtraction (DSA) 6–12 months surgery. If available, magnetic resonance time-of-flight (MR-TOF) evaluated 3 and...