A5057120725- Anesthesia and Sedative Agents
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Nausea and vomiting management
- Receptor Mechanisms and Signaling
- Biomedical and Chemical Research
- Neuroscience and Neural Engineering
- Pesticide Exposure and Toxicity
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular and Diving-Related Complications
- Anesthesia and Pain Management
- Cardiomyopathy and Myosin Studies
- Benford’s Law and Fraud Detection
- Healthcare Decision-Making and Restraints
- Muscle activation and electromyography studies
- Meningioma and schwannoma management
- Cardiac Arrest and Resuscitation
- Environmental Toxicology and Ecotoxicology
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
University Children's Hospital Tübingen
2019-2024
University of Tübingen
2011-2024
Universitätsklinikum Tübingen
2005-2024
Technical University of Munich
2008
American Association of Neuropathologists
2006
University of California, San Francisco
2006
Society of Critical Care Medicine
2006
Heidelberg University
1979
Heidelberg University
1979
General anesthetics are widely used in clinical practice. On the molecular level, these compounds have been shown to modulate activity of various neuronal ion channels. However, functional relevance identified sites mediating essential components general anesthetic state, such as immobility and hypnosis, is still unknown. Using gene-targeting technology, we generated mice harboring a subtle point mutation (N265M) second transmembrane region beta3 subunit GABA(A) receptor. In mice,...
Summary Remimazolam, a short‐acting benzodiazepine, may be used for induction and maintenance of total intravenous anaesthesia, but its role in the management patients with multiple comorbidities remains unclear. In this phase 3 randomised controlled trial, we compared anaesthetic efficacy incidence postinduction hypotension during anaesthesia remimazolam vs. propofol. A 365 (ASA physical status or 4) scheduled elective surgery were assigned randomly to receive (n = 270) propofol 95)....
In Brief BACKGROUND: Benzodiazepines are widely used in clinical anesthesia as premedication, but also to induce general anesthesia. Recent vitro studies suggest that γ-aminobutyric acid type A receptors, harboring a classical high-affinity benzodiazepine binding site, possess another “nonclassical” site for benzodiazepines. At present, it is unclear if, and what extent, this novel nonclassical of relevance the actions benzodiazepines central nervous system. METHODS: Because neocortex...
Premedication of surgical patients with benzodiazepines has become questionable regarding risk-benefit ratio and lack evidence. Though preoperative might alleviate anxiety, a higher risk for adverse events is described, particularly elderly (≥ 65 years). Several German hospitals already withhold benzodiazepine premedication from patients, though evidence this approach lacking. The patient-centred outcome known as global postoperative patient satisfaction recognised substantial quality...
Abstract Background Remimazolam is a relatively new benzodiazepine with growing use in procedural sedation and general anaesthesia. Initiated by case reports, the physical incompatibility of remimazolam ringer’s acetated lactated solution has been reported. More recently, remifentanil, fentanyl, rocuronium, vecuronium, dexmedetomidine, midazolam, have investigated suggested safe for coadministration remimazolam. Apart from other frequently used drugs remains unknown. Methods Sixty-five...
The benzodiazepine midazolam is widely used in critical care medicine. Midazolam has a clinically active metabolite, 1-hydroxymidazolam. contribution of 1-hydroxymidazolam to the effects controversial. aim current study was compare actions and on network activity cortical neurons. depressed neuronal at low concentration 5 nM. When increased, it discharge rates biphasic manner. In comparison, did not depress nanomolar concentrations. Higher concentrations consistently inhibited activity....
Monitoring and automated online analysis of brain electrical activity are frequently used for verifying diseases estimating anesthetic depth in subjects undergoing surgery. However, false diagnosis with potentially catastrophic consequences patients such as intraoperative awareness may result from unnoticed irregularities the process signal analysis. Here we ask whether Benford's Law can be applied to detect accidental or intended modulation neurophysiologic signals. This law states that...
Background The ventral horn is a major substrate in mediating the immobilizing properties of volatile anesthetic sevoflurane spinal cord. In this neuronal network, action potential firing controlled by GABAA and glycine receptors. Both types ion channels are sensitive to anesthetics, but their role anesthetic-induced inhibition locomotor networks not fully understood. Methodology/Principal Findings To compare effects on GABAergic glycinergic inhibitory postsynaptic currents (IPSCs)...
Cortical networks generate diverse patterns of rhythmic activity. Theta oscillations (4-12 Hz) are commonly observed during spatial learning and working memory tasks. The authors ask how etomidate, acting predominantly via gamma-aminobutyric acid type A (GABAA) receptors containing beta2 or beta3 subunits, affects theta activity in vitro.To characterize the effects recorded action potential firing together with local field potentials slice cultures prepared from neocortex beta3(N265M)...
Background Victims of organophosphate intoxication with cholinergic crisis may have need for sedation and anesthesia, but little is known about how anesthetics work in these patients. Recent studies suggest that stimulation impairs gamma-aminobutyric acid type A (GABAA) receptor function. Because GABAA receptors are major targets general anesthetics, the authors investigated interactions between acetylcholine sevoflurane spinal cortical networks. Methods Cultured tissue slices were obtained...
OBJECTIVE The overall benefit of employing a sitting/semisitting position for neurosurgical procedures remains under criticism due to concerns additional risk, especially the risk intraoperative venous air embolism (VAE). aim this single-center cohort study was evaluate frequency and severity VAEs associated complications in patients undergoing neurosurgery lounging position. METHODS From 2010 2020, 1000 patients, including 172 with patent foramen ovale, underwent surgery different...
The neuroactive steroid allopregnanolone (ALLO) is an endogenous allosteric modulator of γ-aminobutyric acid type A (GABAA) receptors. There evidence that ALLO, at physiologically relevant concentrations, modulates GABAA receptor function in the cerebral cortex. widely used anesthetic agent propofol and ALLO share a similar mode molecular action. Here, we ask how receptor-mediated synaptic inhibition action potential firing neurons cultured cortical slices are altered by either or coapplying...
At concentrations close to 1 minimum alveolar concentration (MAC)-immobility, volatile anesthetics display blocking and prolonging effects on gamma-aminobutyric acid type A receptor-mediated postsynaptic currents. It has been proposed that distinct molecular mechanisms underlie these dual actions. The authors investigated whether the or effect of enflurane is altered by a point mutation (N265M) in beta3 subunit receptor. Furthermore, role producing depressant actions neocortical neurons was...