A5044807719- Rheumatoid Arthritis Research and Therapies
- Cardiovascular Function and Risk Factors
- Plant biochemistry and biosynthesis
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Cardiac Valve Diseases and Treatments
- Autoimmune and Inflammatory Disorders Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Spondyloarthritis Studies and Treatments
- Atrial Fibrillation Management and Outcomes
- Anesthesia and Sedative Agents
- Systemic Lupus Erythematosus Research
- Esophageal Cancer Research and Treatment
- Aortic Disease and Treatment Approaches
- Plant and animal studies
- Esophageal and GI Pathology
- Aortic aneurysm repair treatments
- Natural product bioactivities and synthesis
- Metabolism, Diabetes, and Cancer
- Nutritional Studies and Diet
- Respiratory Support and Mechanisms
- Pancreatic function and diabetes
- Cardiac, Anesthesia and Surgical Outcomes
RWTH Aachen University
2015-2024
Australian National University
2008-2023
Universitätsklinikum Aachen
2015-2023
University Hospital Ulm
2018
Maastricht University Medical Centre
2013-2017
FH Aachen
2016
Maastricht University
2009-2014
Departamento de Epidemiología
2013-2014
University of Amsterdam
2014
Leiden University Medical Center
2014
Abstract Background In the EMPA-REG OUTCOME trial (Empagliflozin Cardiovascular Outcome Event Trial) treatment with sodium-glucose cotransporter-2 (SGLT2) inhibitor empagliflozin significantly reduced heart failure hospitalization (HHF) in patients type 2 diabetes mellitus (T2D) and established cardiovascular disease. The early separation of HHF event curves within first 3 months suggest that immediate hemodynamic effects may play a role. However, hitherto no data exist on SGLT2 inhibitors...
To analyze in a prospective cohort study if depressive symptoms are an independent predictor of mortality kidney transplant recipients.Data from 840 transplanted patients followed at single outpatient center were analyzed. Sociodemographic parameters and clinical data collected enrollment (between August 2002 February 2003). Participants completed the Center for Epidemiologic Studies-Depression (CES-D) scale. Depression was defined as CES-D score > or = 18. Data on 5-year outcomes (death...
The terpenoid-dominated essential oils in Australian Myrtaceae mediate many ecological interactions and are important industrially. Of all the significant oil-producing families, is only one for which there no molecular information on terpene biosynthesis. Here we summarise available knowledge biosynthesis its relevance to provide a foundation genetic studies of chemical diversity. There several steps pathway that have potential influencing oil yield, profile composition leaf Myrtaceae....
Objective: To estimate the prevalence of depression among people with diabetes and to examine association comorbid lost productivity health resource utilization in persons without diabetes. Methods: Cross-sectional survey, enrolling 12,643 individuals aged >18 years. Clustered, stratified sampling procedure was utilized. This sample represented 0.16% Hungarian adult population according age, gender, geographic regions. The severity depressive symptoms measured by abbreviated Beck Depression...
Objectives To investigate the relationship of socioeconomic status (SES) on an individual and country level with disease activity in rheumatoid arthritis (RA) explore mediating role uptake costly biological disease-modifying antirheumatic drugs (bDMARDs) this relationship. Methods Data from a cross-sectional multinational study (COMOrbidities RA) were used. Contribution factors residence to score 28-joint assessment (DAS28) was explored regression models, adjusting for relevant clinical...
Abstract Sodium‐glucose cotransporter‐2 ( SGLT2 ) inhibitors have been shown to significantly reduce hospitalization for heart failure HHF and cardiovascular CV mortality in various outcome trials patients with without type 2 diabetes mellitus T2D ). inhibition further increased haemoglobin haematocrit levels by an as yet unknown mechanism, this increase has be independent predictor of the benefit these agents, example, EMPA‐REG OUTCOME trial. The present analysis EMPA haemodynamic study...
Abstract Aims In this prospective, placebo‐controlled, double‐blind, exploratory study, we examined early and more delayed effects of empagliflozin treatment on haemodynamic parameters (primary endpoint: cardiac output) kidney function including acute injury (AKI) in patients with decompensated heart failure (HF). Methods results Patients HF or without diabetes were randomized to 10 mg placebo for 30 days. Haemodynamic, laboratory, urinary assessed after 6 h, 1 day, 3 days, 7 days treatment....
Long-lived trees can accumulate mutations throughout their lifetimes that may influence biotic and abiotic interactions. For example, some Eucalyptus display marked variation in herbivore defence within a single canopy. These "mosaic" support foliage with distinct chemotypes which are differentially favoured by insect vertebrate herbivores, resulting susceptible resistant branches mosaic provide unique opportunity to explore the biosynthesis genetic regulation of chemical defences foliage....
Hypertension is an established risk factor for renal cell cancer (RCC). The renin-angiotensin-aldosterone system (RAAS) regulates blood pressure and closely linked to hypertension. RAAS additionally influences homeostasis of electrolytes (e.g. sodium potassium) fluid. We investigated single nucleotide polymorphisms (SNPs) in their interactions with hypertension intakes sodium, potassium fluid regarding RCC the Netherlands Cohort Study (NLCS), which was initiated 1986 included 120,852...
Objectives To investigate patterns in patient-reported and physician-reported disease outcomes patients with rheumatoid arthritis (RA) from countries different level of socioeconomic development. Methods Data a cross-sectional multinational study (COMOrbidities RA) were used. Contribution welfare (gross domestic product (GDP); low vs high) country residence to (tender joint count, swollen count (SJC), erythrocyte sedimentation rate, activity score based on 28 joints assessment (DAS28)-3v...
Chronic diseases are increasingly prevalent and often occur as multimorbidity. This study compares the impact of musculoskeletal disorders (MSKDs) on health care costs with other chronic diseases, assesses additional MSKDs these outcomes when occurring part multimorbidity.A household survey in a random Dutch population sample (n = 8,904) yielded information sociodemographics, presence 9 physician-confirmed (i.e., musculoskeletal, migraine, diabetes mellitus, cardiovascular, cancer,...
The evidence for an association between occupational asbestos exposure and esophageal, gastric colorectal cancer is limited. We studied this specifically addressing risk differences relatively low high exposure, associated with subtypes, the influence of potential confounders interaction smoking in relation to risk. Using Netherlands Cohort Study (n = 58,279 men, aged 55–69 years at baseline), was estimated by linkage a job-exposure matrix. After 17.3 follow-up, 187 486 1,724 cases were...
There are currently no data on the prevalence of sleep-disordered breathing (SDB) in patients with newly-diagnosed lung cancer. This might be interest given that SDB is associated increased cancer incidence and mortality. Furthermore, intermittent hypoxia has been linked tumor growth progression. The aim current study was to investigate Patients from three centers Germany were screened for using a two-channel screening system (ApneaLink™). defined as an apnea-hypopnea index > 5/h, classified...