A5034623721- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiation Dose and Imaging
- Bone Tumor Diagnosis and Treatments
- Mast cells and histamine
- Cardiac tumors and thrombi
- Sarcoma Diagnosis and Treatment
- Asthma and respiratory diseases
- Transplantation: Methods and Outcomes
- Advanced X-ray and CT Imaging
- Stroke Rehabilitation and Recovery
- Glioma Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Sinusitis and nasal conditions
- Acute Myocardial Infarction Research
- Vascular Anomalies and Treatments
- Vascular Tumors and Angiosarcomas
- Chromatin Remodeling and Cancer
- Antifungal resistance and susceptibility
- Congenital Ear and Nasal Anomalies
University of Tübingen
2016-2025
Universitätsklinikum Tübingen
2019-2024
Essen University Hospital
2024
Klinikum Stuttgart
2024
University Hospital of Bern
2024
University of Bern
2024
Asklepios Klinik Altona
2014
Charité - Universitätsmedizin Berlin
2002
Humboldt-Universität zu Berlin
1998-2002
Deutsches Herzzentrum der Charité
2002
Background: Cardiac myxoma (CM) is the most frequent, cardiac benign tumour and associated with enhanced risk for cerebrovascular events (CVE). Although surgical CM excision only curative treatment to prevent CVE recurrence, in recent reports conservative antiplatelet or anticoagulant agents high-risk patients CM-related has been discussed. Methods: Case records at University Hospital of Tübingen between 2005 2017 were screened identify CVE. Clinical features, brain imaging findings,...
Sex-related differences in acute ischemic stroke may affect outcomes, yet evidence remains inconsistent. This large-scale study investigated sex-related clinical presentation, peri-interventional parameters, and outcomes after endovascular thrombectomy (EVT) for large vessel occlusion (LVO) using data from the German Stroke Registry-Endovascular Treatment (GSR-ET). We analyzed 11.896 EVT patients (52.2% female) GSR-ET (June 2015-December 2021) comparing characteristics, treatment details, by...
Whether thrombectomy compared with best medical treatment (BMT) improves outcome in patients stroke and carotid artery dissection (CAD) is unknown. This was an international observational study based on prospective nationwide Austrian, German, Swiss registries. Patients large vessel occlusion (LVO) due to CAD were according modality (thrombectomy vs BMT including intravenous thrombolysis) admission severity NIH Stroke Scale (NIHSS) <6 NIHSS ≥6. The primary the favorable functional (modified...
Background The impact of stent retriever size on mechanical thrombectomy (MT) outcomes remains uncertain. We aim to clarify the influence MT by analyzing data from two national prospective registries. Methods A retrospective analysis was performed French and German registries including consecutive patients with anterior circulation large vessel occlusion who underwent Solitaire or without additional aspiration. Efficacy were successful reperfusion complete reperfusion. Safety included any...
Background: Basophils (BA) and mast cells (MC) are important effector in allergic reactions. Development, growth cell functions regulated by a network of cytokines, other ligands, respective surface antigens. Methods: We examined the expression novel CD antigens on human BA, lung MC, BA line KU‐812, MC HMC‐1. Expression was analyzed monoclonal antibodies (mAb) HLDA8 workshop flow cytometry. Results: were found to stain positive for CXCR1 (CD181), CCR1 (CD191), CCR2 (CD192), CCR7 (CD197),...
Endovascular and surgical treatments of stenosis the extracranial internal carotid artery (ICA) are common procedures, yet both introduce a risk restenosis due to endothelial hyperplasia. Drug-coated balloons (DCBs) designed decrease neointimal hyperplasia, however rarely used in neurovascular setting. This study retrospectively analyzes mid-term results DCB-treated in-stent (ISR) ICA.
Vessel-encoded arterial spin labeling (VE-ASL) is able to provide noninvasive information about the contribution of individual arteries cerebral perfusion. The aim this study was compare VE-ASL diagnostic standard digital subtraction angiography (DSA) with respect its ability visualize vascular territories.
Goldenhar syndrome is a developmental disorder presenting with orofacial and vertebral anomalies, which are also accompanied by abnormalities in other organs. We examined temporal bone changes special emphasis on inner ear these patients.A retrospective review of 7 new cases addition to previously published series 14 clinically diagnosed was carried out search for anomalies. In addition, imaging studies from the literature were summarized compared our results.Departments Neuroradiology...
Current standard care for acute cerebral venous sinus thrombosis (CVST) includes either intravenous heparin or subcutaneous low-molecular-weight heparin, but patients with refractory CVST, despite adequate anticoagulation therapy, may benefit from mechanical thrombectomy (MT). A retrospective study of who underwent MT between 2011 and 2019, was performed looking at procedure success rate clinical outcomes. Two raters evaluated the system every patient before after intervention using...
Rationale: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs. Aims: PROOF investigates use of normobaric (NBO) therapy within 6 h symptom onset/notice brain-protective bridging endovascular acute intracranial anterior-circulation occlusion. Methods and design: Randomized (1:1), standard treatment-controlled, open-label,...
Background This study reports a multicenter experience of using hydrophilic polymer-coated (HPC) flow diverters with prasugrel single antiplatelet therapy to treat ruptured aneurysms subarachnoid hemorrhage (SAH). Methods Patients treated for intracranial within 30 days after SAH p64/p48 MW HPC diverter were prospectively identified. Clinical presentation and outcomes, periprocedural postprocedural complications, degree occlusion at follow-up evaluated. Results A total 84 patients in 88...
Rhino-orbital-cerebral mucormycosis is a rapidly progressive and often fatal fungal infection caused by molds of the order Mucorales, particularly affecting immunocompromised individuals. This notorious for its angioinvasive properties, enabling fungi to invade blood vessels leading tissue necrosis. We report clinical course 59-year-old Caucasian man with poorly controlled type 2 diabetes (HbA1c 16.8%) who presented unilateral headache, left-sided facial numbness, incomplete left ocular...
Background: Interhospital transfer for endovascular treatment (EVT) within neurovascular networks might result in of patients who will not undergo EVT (futile transfer). Limited evidence exists on factors associated with the primary patient selection interhospital from stroke centers (PSCs) to comprehensive (CSCs), or EVT-workflow parameters that may render a futile. Methods: A prospective, registry-based study was performed between July 1, 2017 and June 30, 2018, at hub-and-spoke network...
Abstract Background. The present study aimed to analyse potential prognostic factors, with emphasis on tumour volume, in determining progression free survival (PFS) for malignancies of the nasal cavity and paranasal sinuses. Patients methods. Retrospective analysis 106 patients primary sinonasal treated followed-up between March 2006 October 2012. Possible predictive parameters PFS were entered into univariate multivariate Cox regression analysis. Kaplan-Meier curve included age, sex,...
Abstract Background Acute stroke treatment with intracranial thrombectomy and of ipsilateral carotid artery stenosis/occlusion (“tandem lesion”, TL) in one session is considered safe. However, the risk stent restenosis after TL high, antiplatelet therapy (APT) preventing must be well balanced to avoid hemorrhage. We investigated safety 90-day outcome patients receiving under triple-APT, focused on stent-patency possible disadvantageous comorbidities. Methods Patients setting acute between...
Introduction Cerebral venous sinus thrombosis (CVST) is a rare cerebrovascular disease that primarily affects adults. However, its occurrence in paediatric patients presents unique challenges. This paper discusses case of severe CVST and thrombocytopenia following adenovirus infection, resembling vaccine-induced immune thrombotic (VITT). The aim this study to serologically characterize antibodies against platelet factor 4 (PF4)/heparin detected the serum investigate their ability induce ex vivo.
Abstract Background Acute stroke treatment with intracranial thrombectomy and of ipsilateral carotid artery stenosis/occlusion (“tandem lesion”, TL) in one session is considered safe. However, the risk stent restenosis after TL high, antiplatelet therapy (APT) preventing must be well balanced to avoid hemorrhage. We investigated safety 90-day outcome patients receiving under triple-APT, focused on stent-patency possible disadvantageous comorbidities. Methods Patients setting acute between...
Durale arteriovenöse Fisteln (dAVFs) sind pathologische Shunts zwischen meningealen Arterien und venösen Sinus oder kortikalen Venen bzw. medullären bei den spinalen Fisteln.