A5008438428- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Peripheral Neuropathies and Disorders
- Advanced MRI Techniques and Applications
- RNA regulation and disease
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Ultrasound and Hyperthermia Applications
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Cerebral Venous Sinus Thrombosis
- Systemic Sclerosis and Related Diseases
- Brain Metastases and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Herpesvirus Infections and Treatments
- Long-Term Effects of COVID-19
- Neurological disorders and treatments
- Neurological Disease Mechanisms and Treatments
- Single-cell and spatial transcriptomics
- Migraine and Headache Studies
- Spinal Dysraphism and Malformations
- Viral Infections and Immunology Research
- MRI in cancer diagnosis
Johns Hopkins University
2015-2025
Johns Hopkins Medicine
2020-2025
Vita-Salute San Raffaele University
2015-2025
IRCCS Humanitas Research Hospital
2024-2025
National Institutes of Health
2015-2025
National Institute of Neurological Disorders and Stroke
2014-2025
Humanitas University
2024-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2011-2025
UCLouvain
2024
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) feasibility noninvasively imaging mapping them vivo with high-resolution, clinical MRI. On T2-FLAIR T1-weighted black-blood imaging, enhance gadobutrol, a gadolinium-based contrast agent high propensity to extravasate across permeable capillary endothelial barrier, but not gadofosveset, blood-pool agent. The topography these vessels, running alongside dural venous sinuses,...
In multiple sclerosis (MS), chronic active lesions, which previously could only be detected at autopsy, can now identified on susceptibility-based magnetic resonance imaging (MRI) in vivo as non-gadolinium-enhancing lesions with paramagnetic rims. Pathologically, they feature smoldering inflammatory demyelination the edge, remyelination failure, and axonal degeneration. To our knowledge, prospect of long-term monitoring makes it possible for first time to determine their contribution...
<b>Objective:</b> This study explores default-mode network (DMN) abnormalities in patients with secondary progressive (SP) and primary (PP) multiple sclerosis (MS) whether such correlate cognitive impairment damage to selected white matter (WM) fiber bundles, quantified using diffusion tensor (DT) MRI tractography. <b>Methods:</b> Resting state (RS) functional DT data were acquired from 33 SPMS, 24 PPMS, controls. Independent component analysis (ICA) was used identify the DMN. SPM5 assess...
BACKGROUND. In some active multiple sclerosis (MS) lesions, a strong immune reaction at the lesion edge may contain growth and thereby isolate from surrounding parenchyma. Our previous studies suggest that this process involves opening of blood-brain barrier in capillaries edge, seen on MRI as centripetal contrast enhancement colocalized phase rim. We hypothesized using these features to characterize early evolution will allow vivo tracking tissue degeneration and/or repair, thus improving...
In multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions the brain (the "central vein sign") improves pathological MS diagnosis, comprehensive evaluation this MRI biomarker MS-mimicking inflammatory and/or autoimmune diseases, such as central nervous system (CNS) vasculopathies, lacking. multicenter...
Chronic active lesions (CAL) in multiple sclerosis (MS) have been observed even patients taking high-efficacy disease-modifying therapy, including B-cell depletion. Given that CAL are a major determinant of clinical progression, progression independent relapse activity (PIRA), understanding the predicted and real-world effects targeting specific lymphocyte populations is critical for designing next-generation treatments to mitigate chronic inflammation MS.We analyzed published single-cell...
Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a smoldering inflammatory activity is present from the earliest stages of disease underlies progression disability, which proceeds relentlessly independently clinical radiological relapses (PIRA). The complex system pathological events driving "chronic" worsening likely linked with early accumulation compartmentalized inflammation within central nervous as well insufficient repair phenomena mitochondrial...
In multiple sclerosis (MS), accurate, in vivo characterization of dynamic inflammatory pathological changes occurring newly forming lesions could have major implications for understanding disease pathogenesis and mechanisms tissue destruction. Here, we investigated the potential ultrahigh-field magnetic resonance imaging (MRI; 7T), particularly phase combined with contrast enhancement, to provide new insights acute MS lesions.
Cervical cord damage is likely to contribute the accumulation of disability in multiple sclerosis (MS) and can be quantified vivo using MRI. We used conventional diffusion tensor (DT) MRI to: (a) define temporal evolution intrinsic tissue injury atrophy cervical from MS patients, (b) investigate how these two aspects are interrelated (c) assess correlation metrics with concomitant brain disability. Conventional DT were obtained 42 patients 9 healthy controls at baseline after a mean...
<b>Objective: </b> We used voxel-based morphometry (VBM) to assess the pattern of regional gray matter (GM) loss in patients with pediatric multiple sclerosis (MS) and its relation Expanded Disability Status Scale (EDSS) score, disease duration, extent T2 lesion load (LL). <b>Methods: From 28 relapsing-remitting MS (16 girls; mean age = 14.4 years, range 7 16 years) 21 matched controls, dual-echo three-dimensional T1-weighted magnetization prepared rapid acquisition gradient echo sequences...
Diffusion tensor MRI-based tractography was used to investigate white matter (WM) changes in the major limbic (i.e., fornix and cingulum) cortico-cortical association pathways [i.e., uncinate fasciculus, inferior fronto-occipital longitudinal fasciculus (ILF), superior corpus callosum] 25 Alzheimer's disease (AD) patients, 19 amnestic mild cognitive impairment (aMCI) 15 healthy controls (HC). Mean diffusivity (MD), fractional anisotropy (FA), as well axial (DA) radial (DR) diffusivities were...
Benedetti F, Absinta M, Rocca MA, Radaelli D, Poletti S, Bernasconi A, Dallaspezia Pagani E, Falini Copetti Colombo C, Comi G, Smeraldi Filippi M. Tract-specific white matter structural disruption in patients with bipolar disorder. Bipolar Disord 2011: 13: 414–424. © 2011 The Authors. Journal compilation John Wiley & Sons A/S. Objectives: A growing body of evidence suggests that, independent localized brain lesions, mood disorders can be associated dysfunction networks involved the...
In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports association with severity clinical disease. We studied potential role in differential diagnosis, screening an international multicenter research‐based sample 438 individuals affected different neurological conditions (MS, other inflammatory, infectious, non‐inflammatory conditions). Paramagnetic rim lesions,...
In Assessment of OraL Laquinimod in PrEventing ProGRession Multiple SclerOsis (ALLEGRO), a phase III study relapsing-remitting multiple sclerosis (RRMS), oral laquinimod slowed disability and brain atrophy progression, suggesting may reduce tissue damage MS. MRI techniques sensitive to the most destructive aspects disease were used further investigate laquinimod's potential effects on inflammation neurodegeneration.1106 RRMS patients randomised 1:1 receive once-daily (0.6 mg) or placebo for...
<h3>BACKGROUND AND PURPOSE:</h3> MR imaging–pathologic studies have reported that paramagnetic rims on 7T susceptibility-based imaging identify, in vivo, the subset of MS lesions with compartmentalized inflammation at lesion edge and associated remyelination failure. Here, we assessed reliability detecting these high-resolution 3T phase images. <h3>MATERIALS METHODS:</h3> High-resolution T2* was collected 20 patients (3D segmented EPI, 0.65 mm<sup>3</sup>) (2D gradient-echo, 0.2 × 1 mm)...
<h3>Objective:</h3> To assess the prevalence and specificity of leptomeningeal enhancement (LME) on postcontrast T2–fluid-attenuated inversion recovery (FLAIR) MRI in multiple sclerosis (MS) compared to a variety inflammatory noninflammatory neurologic conditions assessed 2 academic research hospitals. <h3>Methods:</h3> On 3T T2-FLAIR images, presence focal gadolinium was evaluated compartment 254 people with non-MS or neurotropic viral infections. Based their clinical diagnosis, patients...
Damage to the myelin sheath and neuroaxonal unit is a cardinal feature of multiple sclerosis; however, detailed characterization interaction between axon damage in vivo remains challenging. We applied water multi-shell diffusion imaging quantify relative axons (i) among different lesion types; (ii) normal-appearing tissue; (iii) across sclerosis clinical subtypes healthy controls. also assessed relation focal myelin/axon with disability serum neurofilament light chain as global biological...