A5010849210- Muscle Physiology and Disorders
- Signaling Pathways in Disease
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
- Adenosine and Purinergic Signaling
- Liver Disease Diagnosis and Treatment
- Nuclear Receptors and Signaling
- Pancreatic function and diabetes
- Tryptophan and brain disorders
- Regulation of Appetite and Obesity
- Exercise and Physiological Responses
- Neurogenesis and neuroplasticity mechanisms
- Cancer Research and Treatments
- Bone Metabolism and Diseases
- Circadian rhythm and melatonin
- Immune cells in cancer
- Metabolism, Diabetes, and Cancer
- Nuclear Structure and Function
- Adipokines, Inflammation, and Metabolic Diseases
- Virus-based gene therapy research
- NF-κB Signaling Pathways
- Phosphodiesterase function and regulation
- Renin-Angiotensin System Studies
- Inflammasome and immune disorders
- Sulfur Compounds in Biology
Gladstone Institutes
2012-2021
Second Genome (United States)
2020
University of California, San Francisco
2012-2019
Stone Clinic
2013
Universitat Pompeu Fabra
2008
Biomedical Research Networking Center on Neurodegenerative Diseases
2008
Centre for Genomic Regulation
2004-2007
In the fatal degenerative Duchenne muscular dystrophy (DMD), skeletal muscle is progressively replaced by fibrotic tissue. Here, we show that fibrinogen accumulates in dystrophic muscles of DMD patients and mdx mice. Genetic loss or pharmacological depletion these mice reduced fibrosis progression. Our results demonstrate fibrinogen–Mac-1 receptor binding, through induction IL-1β, drives synthesis transforming growth factor-β (TGFβ) macrophages, which turn induces collagen production...
p38 MAPK and nuclear factor-kappaB (NF-kappaB) signaling pathways have been implicated in the control of skeletal myogenesis. However, although is recognized as a potent activator myoblast differentiation, role NF-kappaB remains controversial. Here, we show that activated only differentiating myocytes, whereas activity present both proliferation differentiation stages. activation was found to be dependent on during being an effector p38, thus providing novel mechanism for promyogenic effect...
Recent genetic evidence supports a link between microglia and the complement system in Alzheimer’s disease (AD). In this study, we uncovered novel role for microglial receptor 3 (CR3) regulation of soluble β-amyloid (Aβ) clearance independent phagocytosis. Unexpectedly, ablation CR3 human amyloid precursor protein–transgenic mice results decreased, rather than increased, Aβ accumulation. line with these findings, cultured lacking are more efficient wild-type cells at degrading extracellular...
Obesity is associated with an increased risk of depression. The aim the present study was to investigate whether obesity a causative factor for development depression and what molecular pathway(s) that link these two disorders. Using lipidomic transcriptomic methods, we identified mechanism links exposure high-fat diet (HFD) in mice alterations hypothalamic function lead Consumption HFD selectively induced accumulation palmitic acid hypothalamus, suppressed 3′, 5′-cyclic AMP (cAMP)/protein...
Insulin resistance is a key factor in the etiology of type 2 diabetes. Insulin-stimulated glucose uptake mediated by transporter 4 (GLUT4), which expressed mainly skeletal muscle and adipose tissue. translocation GLUT4 from its intracellular compartment to plasma membrane regulated small guanosine triphosphate hydrolases (GTPases) essential for maintenance normal homeostasis. Here we show that p75 neurotrophin receptor (p75(NTR)) regulator insulin resistance. p75(NTR) knockout mice increased...
Extracellular adenosine triphosphate (eATP) released by damaged cells, and its purinergic receptors, comprise a crucial signaling network after injury. Purinergic receptor P2X7 (P2RX7), major driver of NOD-like family pyrin domain containing 3 (NLRP3) inflammasome activation IL-1β processing, has been shown to play role in liver injury murine diet- chemically-induced models. It is unclear, however, whether P2RX7 plays non-alcoholic steatohepatitis (NASH) which cell type the main target...
The p75 neurotrophin receptor (p75<sup>NTR</sup>) is a member of the tumor necrosis factor superfamily with widespread pattern expression in tissues such as brain, liver, lung, and muscle. mechanisms that regulate <i>p75<sup>NTR</sup></i> transcription nervous system its other remain largely unknown. Here we show an oscillating gene regulated by helix-loop-helix factors CLOCK BMAL1. promoter contains evolutionarily conserved noncanonical E-box enhancers. Deletion mutagenesis...
Obesity is associated with an increased risk of depression. The aim the present study was to investigate whether obesity a causative factor for development depression and what molecular pathway(s) that link these two disorders. Using lipidomic transcriptomic methods we identified mechanism links exposure high-fat diet (HFD) in mice alterations hypothalamic function lead Consumption HFD selectively induced accumulation palmitic acid hypothalamus, suppressed 3´, 5´-cyclic AMP (cAMP)/protein...
Abstract The gut microbiota has emerged as an important player in cancer pathology, and increasing evidence supports its role clinical response to immune checkpoint inhibitor (ICI) therapy. However, the specific microbiome-derived factors responsible for improved ICI therapy remain unknown. Second Genome developed a unique discovery platform identify, screen, validate peptides that promote immunotherapy. Using our multitechnology meta-analysis of published datasets characterizing baseline...