A5006829573- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Autophagy in Disease and Therapy
- Cardiac Valve Diseases and Treatments
- Neonatal Respiratory Health Research
- Zebrafish Biomedical Research Applications
- Machine Learning in Bioinformatics
- Genetic diversity and population structure
- Congenital heart defects research
- Genomics and Phylogenetic Studies
- ATP Synthase and ATPases Research
- Tissue Engineering and Regenerative Medicine
- Birth, Development, and Health
- Gene expression and cancer classification
- Genomics and Chromatin Dynamics
- Adenosine and Purinergic Signaling
- Plant nutrient uptake and metabolism
- Lipid metabolism and biosynthesis
- T-cell and B-cell Immunology
- Calcium signaling and nucleotide metabolism
- Immune responses and vaccinations
- Bioinformatics and Genomic Networks
- Identification and Quantification in Food
- Hepatitis C virus research
- HIV Research and Treatment
Max Delbrück Center
2024-2025
University of Bonn
2015-2024
Bonn Aachen International Center for Information Technology
2015-2016
University of Qom
2013-2015
During embryogenesis, the fetal liver becomes main hematopoietic organ, where stem and progenitor cells as well immature mature immune form an intricate cellular network. Hematopoietic (HSCs) reside in a specialized niche, which is essential for their proliferation differentiation. However, molecular determinants contributing to this HSC niche remain largely unknown. Macrophages are first differentiated found developing liver, they important erythropoiesis by promoting erythrocyte maturation...
Early diagnosis of lung cancers and distinction between the tumor types (Small Cell Lung Cancer (SCLC) Non-Small (NSCLC) are very important to increase survival rate patients. Herein, we propose a diagnostic system based on sequence-derived structural physicochemical attributes proteins that involved in both tumors via feature extraction, selection prediction models. 1497 computed features selected by 12 attribute weighting models finally machine learning consist seven SVM models, three ANN...
Hepatitis C virus (HCV) causes chronic hepatitis in 2-3% of world population and remains one the health threatening human viruses, worldwide. In absence an effective vaccine, therapeutic approach is only option to combat C. Interferon-alpha (IFN-alpha) ribavirin (RBV) combination alone or with recently introduced new direct-acting antivirals (DAA) used treat patients infected HCV. The present study utilized feature selection methods (Gini Index, Chi Squared machine learning algorithms) other...
<title>Abstract</title> Older adults are particularly vulnerable to infectious diseases, and vaccines often less effective in this population due immunosenescence, which is characterized by diminished B T memory responses. Autophagy believed underlie many facets of cellular aging, including immunosenescence. It crucial for maintaining cell functions but declines with age, along the endogenous metabolite spermidine that helps maintain autophagy levels. We conducted a double-blind, randomized,...
Finding efficient analytical techniques is overwhelmingly turning into a bottleneck for the effectiveness of large biological data. Machine learning offers novel and powerful tool to advance classification modeling solutions in molecular biology. However, these methods have been less frequently used with empirical population genetics In this study, we developed new combined approach data analysis using microsatellite marker from our previous studies olive populations machine algorithms....
Abstract Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate histone H3.3 chaperone Daxx, a element repressor inactivated in myeloid leukaemia other neoplasms, protection from inflammatory disease. Loss Daxx alters chromatin landscape, distribution marks haematopoietic progenitors, leading engagement Pu.1-dependent transcriptional programme for...
CRELD1 (Cysteine-Rich with EGF-Like Domains 1) is a risk gene for non-syndromic atrioventricular septal defects in human patients. In mouse model, Creld1 has been shown to be essential heart development, particularly septum and valve formation. However, due the embryonic lethality of global knockout (KO) mice, its cell type-specific function during peri- postnatal stages remains unknown.Here, we generated conditional KO mice lacking either endocardium (KOTie2) or myocardium (KOMyHC). Using...
<title>Abstract</title> Kupffer cells (KCs) are tissue-resident macrophages which colonize the developing liver early during embryogenesis<sup>1</sup>. Throughout development and adulthood, KCs have distinct core functions that essential for organismal homeostasis, such as supporting fetal erythropoiesis well postnatal erythrocyte recycling metabolism<sup>2</sup>. start to acquire their tissue-specific transcriptional signature immediately after colonizing liver, mature together with tissue,...
Abstract T cell immunity is impaired during ageing, particularly in memory responses needed for efficient vaccination. Autophagy and asymmetric division (ACD) are biological mechanisms key to formation, which undergo a decline upon ageing. However, despite the fundamental importance of these processes cellular function, link between ACD vivo fate decisions has remained highly correlative cells field mammalian overall. Here we provide robust causal evidence linking our data consistent with...
Abstract Aims Degenerative mitral valve dystrophy (MVD) leading to prolapse is the most frequent form of MV disease, and there currently no pharmacological treatment available. The limited understanding pathophysiological mechanisms MVD limits our ability identify therapeutic targets. This study aimed reveal main pathways involved in via multimodality imaging transcriptomic analysis new unique knock-in (KI) rat model for FilaminA-P637Q (FlnA-P637Q) mutation associated-MVD. Methods results...
ABSTRACT A hallmark of obesity is a pathological expansion white adipose tissue (WAT), accompanied by marked dysfunction and fibrosis. Autophagy promotes adipocyte differentiation lipid homeostasis, but its role in obese adipocytes remains incompletely understood. Here, we demonstrate that autophagy key tissue-specific regulator WAT remodelling diet-induced obesity. Importantly, loss substantially exacerbates pericellular fibrosis visceral WAT. Change architecture correlates with increased...
Abstract During embryogenesis, the fetal liver becomes main hematopoietic organ, where stem and progenitor cells as well immature mature immune form an intricate cellular network. Hematopoietic (HSCs) reside in a specialized niche, which is essential for their proliferation differentiation. However, molecular determinants contributing to this HSC niche remain largely unknown. Macrophages are first differentiated found developing liver, they important erythropoiesis by promoting erythrocyte...
Abstract Introduction Mitral Valve Prolapse (MVP) affects 3% of the population and is characterized by a heterogeneous mitral leaflet remodeling. The pathophysiological mechanisms involved in MVP development are not fully understood, only therapeutic option remains surgical valve replacement. We previously identified FLNA as first gene causing recently generated unique knock-in rat model for FLNA-P637Q mutation that now paves road to study molecular development. Purpose aim our was...
Introduction: Mitral Valve Prolapse (MVP) is observed in 3% of the population. The pathophysiological mechanisms leading to MVP remain elusive and only therapeutic option perform valve surgery. We previously identified FLNA as first gene causing generated a unique knock-in (KI) rat model for FLNA-P637Q mutation. Hypothesis: assessed hypothesis that pathophysiology multifactorial. Methods: 5 WT 10 KI rats were morphologically, functionally histologically evaluated at 3, 6 13 weeks based on 2D...