A5086423382- Machine Learning in Bioinformatics
- Genomics and Phylogenetic Studies
- Electromagnetic Fields and Biological Effects
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Heat shock proteins research
- Genomics and Chromatin Dynamics
- Protein Interaction Studies and Fluorescence Analysis
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Protein Structure and Dynamics
- Immunotherapy and Immune Responses
- Bioinformatics and Genomic Networks
- Monoclonal and Polyclonal Antibodies Research
- thermodynamics and calorimetric analyses
- vaccines and immunoinformatics approaches
- 3D Printing in Biomedical Research
- Magnetic and Electromagnetic Effects
- Photoreceptor and optogenetics research
- Gene expression and cancer classification
- Neuroscience and Neural Engineering
- Gene Regulatory Network Analysis
- Cancer Cells and Metastasis
- Mathematical Biology Tumor Growth
- DNA Repair Mechanisms
University of Tehran
2016-2025
Pasteur Institute of Iran
2023
National Institute of Genetic Engineering and Biotechnology
2005
University of California, Berkeley
1980
Lawrence Berkeley National Laboratory
1980
University of California, San Francisco
1980
Abstract Wound healing is a complex process and rapid necessitates proper micro-environment. Therefore, design fabrication of an efficacious wound dressing impressive innovation in the field healing. The fabricated this scenario was designed using combination appropriate coagulating anti-bacterial materials like fibrinogen (as agent), nisin ethylenediaminetetraacetic acid alginate agent). Biophysical characterization showed that interaction associated with minor changes secondary structure...
Mesoporous silica nanoparticles (MSNs) have ideal characteristics as next generation of controlled drug delivery systems. In this study, a MSN-based nanocarrier was fabricated and gold nanoparticle (GNP)-biotin conjugates were successfully grafted onto the pore outlets prepared MSN. This bioconjugate served capping agent with peptide-cleavable linker sensitive to matrix metalloproteinases (MMPs), which are overexpressed extracellular proteolytic enzymes in cancerous tissue. The nanocarriers...
Early diagnosis of lung cancers and distinction between the tumor types (Small Cell Lung Cancer (SCLC) Non-Small (NSCLC) are very important to increase survival rate patients. Herein, we propose a diagnostic system based on sequence-derived structural physicochemical attributes proteins that involved in both tumors via feature extraction, selection prediction models. 1497 computed features selected by 12 attribute weighting models finally machine learning consist seven SVM models, three ANN...
Among the different breast cancer subsets, triple-negative (TNBC) has worst prognosis and limited options for targeted therapies. Immunotherapies are emerging as novel treatment opportunities TNBC. However, surging immune response elicited by immunotherapies to eradicate cells can select resistant cells, which may result in escape tumor evolution progression. Alternatively, maintaining equilibrium phase of be advantageous keeping a long-term presence small-size residual tumor....
Extremely low-frequency electromagnetic field (ELF-EMF) induces biological effects on different cells through various signaling pathways. To study the impact of ELF-EMF living under an optimal physiological condition, we have designed and constructed a novel system that eliminates several limitations other systems. Apoptosis cell number were assessed by flow cytometry Trypan Blue dye exclusion method, respectively. In vitro survival was evaluated colony formation assay. The distribution in...
Considering the central role of oxidative stress in onset and progress Parkinson's diseases (PD), search for compounds with antioxidant properties has attracted a growing body attention. Here, we compare neuroprotective effect bulk nano forms polyphenolic fraction propolis (PFP) against rotenone-induced cellular animal models PD. Mass spectrometric analysis PFP confirmed presence multiple polyphenols including kaempferol, naringenin, coumaric acid, vanillic ferulic acid. In vitro experiments...
The age-old discipline of plant therapy has gained renewed importance through the utilization plants for synthesis metal nanoparticles. However, toxicity testing and characterization recently synthesized nanomaterials are essential to evaluating their appropriate application.
Human serum albumin (HSA) is a soluble blood protein which binds to small molecules (such as drugs and toxins) transfers them within the circulation. In this research, interaction of diazinon, toxic organophosphate, with HSA was investigated. Various biophysical methods such fluorescence, ultraviolet–visible (UV-vis), Fourier transform infrared spectroscopy, molecular docking were utilized characterize binding properties diazinon under physiological-like condition. The UV-vis spectroscopy...
Drug repurposing is a swift, safe, and cheap drug discovery method. Melanoma disorders present low survival high mortality rates are challenging to diagnose treat. Moreover, there volume of worldwide investigations that attempting find melanoma-related genes influence, which can be identified as responsive targets for reliable treatment. In this study, we used wide range data analyses analyze over 1100 proteins influence with respect cutaneous malignant melanoma. Our analysis included...
Malignant gliomas (glioblastoma multiforme) are the most aggressive of primary brain tumors. Radiotherapy is an important tool for treatment cancer but malignant usually resistant to radiotherapy and other adjuvant therapies. Thus new drugs needed increase efficiency in order improve therapeutic outcome tumor patients. Recent investigations showed that gossypol, natural polyphenolic compound produced by cotton plants, a promising agent against solid The current study was defined evaluate...
It has been shown that noscapine, an opium-derived phthalideisoquinoline alkaloid is currently being used as oral antitussive drug, induces apoptosis in myeloid leukemia cells. The molecular mechanism responsible for the anticancer effects of noscapine poorly understood. In current study, apoptotic on two cell lines, apoptosis-proficient HL60 cells and apoptosis-resistant K562 cells, were analyzed. An increase activity caspase-2, -3, -6, -8 -9, poly(ADP ribose) polymerase cleavage, detection...
Triple-negative breast cancer (TNBC) is a molecular subtype of malignancy with poor clinical prognosis. There growing evidence that some chemotherapeutic agents induce an adaptive anti-tumor immune response. This reaction has been proposed to maintain the equilibrium phase immunoediting process and control tumor growth by immunological dormancy. We recently reported model dormancy based on murine 4T1 TNBC model. Treatment cells in vitro high-dose chemotherapy activated type I interferon...
Heat shock protein 70 (Hsp70), a induced in cells exposed to sublethal heat shock, is present all living and has been highly conserved during evolution. The aim of the current study was determine role proteins resistance prostate carcinoma cell line spheroids hyperthermia. In vitro, expression Hsp70 by DU 145 line, when cultured as monolayer or multicellular spheroids, studied using Western blotting enzyme‐linked immunosorbent assay methods. level spheroid cultures for up 26 days at 37°C...
Purpose: The aim of the present study was to investigate whether induction differentiation by hyperthermia is accompanied apoptosis and necrosis further evaluate benefits using as a inducing physical modality.Materials method: Differentiation evaluated in K562 erythroleukaemia cells measuring haemoglobin synthesis flow cytometric measurement glycophorin A expression. Apoptosis measured Annexin-V-FITC Propidium Iodide (PI) double staining assay. also morphologically with acridine...
In this paper a novel genetic algorithm is presented for the dyad motif finding problem. The uses multi-objective fitness function based on sum of pairs, number matches, and information content. individuals required population pool in are optimized by Gibbs sampling method. Also, new crossover mutation operators designed. implemented tested different types real datasets. results compared with other well-known algorithms effectiveness our shown.
The emergence of phenotypic diversity in a population cells and their arrangement space time is one the most fascinating features living systems. In fact, understanding multicellularity unthinkable without explaining proximate ultimate causes cell differentiation space. Simpler forms can be found unicellular organisms, such as bacterial biofilm, where reversible results phenotypically diverse populations. this manuscript, we attempt to start with simple case nongenetic construct model...