A5062646685- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Immune cells in cancer
- Genetic factors in colorectal cancer
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- S100 Proteins and Annexins
- Hedgehog Signaling Pathway Studies
- Mesenchymal stem cell research
- Colorectal Cancer Treatments and Studies
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Cancer-related gene regulation
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Mast cells and histamine
- Cancer Mechanisms and Therapy
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Protease and Inhibitor Mechanisms
- Radiomics and Machine Learning in Medical Imaging
University of Fribourg
2015-2024
University of Lausanne
2007-2023
University Hospital of Lausanne
1995-2023
École Polytechnique Fédérale de Lausanne
2009-2023
Adolphe Merkle Institute
2019
Swiss Integrative Center for Human Health
2018
University of Basel
2012
Friedrich Miescher Institute
2012
Breast Center
2011
University of Geneva
2011
Integrins are heterodimeric cell surface proteins that mediate both cell-cell and cell-extracellular matrix interactions. We others recently identified cDNAs encoding a novel integrin beta subunit, 7, in lymphocytes. have now detected 7 mRNA mouse TK-1 T lymphoma cells, which known to express the putative Peyer's patch homing receptor alpha 4 P. used an anti-peptide antiserum mAb against subunit show cells as only associated with 4. conclude P identical. also activated peripheral blood 7....
Metastatic breast tumor cells display an epithelial-mesenchymal transition (EMT) that increases cell motility, invasion, and dissemination. Although the transcription factor Twist1 has been shown to contribute EMT cancer metastasis, signaling pathways regulating activity are poorly understood. Here, we show is ubiquitously phosphorylated in 90% of 1,532 invasive human tumors. Akt/protein kinase B (PKB)-mediated phosphorylation promotes metastasis by modulating its transcriptional target...
Radiotherapy is a widely used treatment option in cancer. However, recent evidence suggests that doses of ionizing radiation (IR) delivered inside the tumor target volume, during fractionated radiotherapy, can promote invasion and metastasis. Furthermore, tissues surround area are also exposed to low IR lower than those mass, because external radiotherapy through multiple beams, order prevent damage organs at risk. The biological effects these on healthy tissue surrounding area, particular...
Tenascin is a nonubiquitous extracellular matrix protein mainly expressed during morphogenesis in embryonal life. In adults it reappears malignant tumors and inflammation tissue repair. Extracellular proteins can alter cell morphology, adhesion, motility, differentiation, growth. Since cells of the immune system express receptors for matrix, we investigated effects tenascin on human monocytes T B lymphocytes. inhibited monocyte adhesion to fibronectin enhanced LFA-1 (lymphocyte...
Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different isoforms ROS-generating NOX enzymes expressed the vasculature provide distinct signaling cues through differential localization activation. We show that mice deficient NOX1, but not NOX2 or NOX4, have impaired NOX1 expression activity is increased primary mouse human cells upon angiogenic stimulation. silencing decreases migration...
Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular estrogen receptor negative (ER−) cancers, by reducing rates of recurrences. It is assumed that the (neo)adjuvant chemotherapy are due killing disseminated, residual cells, however, there no formal evidence for it. Here, we experimental ER− cells survived high-dose Doxorubicin Methotrexate based elicit a state immunological dormancy. Hallmark this dormant phenotype sustained activation...
Colorectal cancer (CRC) is one of the most common worldwide. Chronic inflammation contributes to CRC development and progression. Emodin, a natural anthraquinone derivative with anti-oxidant, anti-inflammatory, anti-tumor activities. We used AOM/DSS model colitis-associated intestinal tumorigenesis characterize effect Emodin on at weeks 3, 5, 14 after initiation AOM. At all three time points, (50 mg/kg) reduced inflammatory cell (i.e. CD11b + F4/80 ) recruitment, cytokine TNFα, IL1α/β, IL6,...
The formation of new blood vessels (angiogenesis) and lymphatic (lymphangiogenesis) promotes tumor outgrowth metastasis. Previously, it has been demonstrated that bone marrow-derived cells (BMDC) can contribute to angiogenesis. However, the role BMDC in lymphangiogenesis largely remained elusive. Here, we demonstrate by marrow transplantation/reconstitution genetic lineage-tracing experiments integrate into tumor-associated Rip1Tag2 mouse model insulinoma TRAMP-C1 prostate cancer...
Radiotherapy is widely used to treat human cancer. Patients locally recurring after radiotherapy, however, have increased risk of metastatic progression and poor prognosis. The clinical management postradiation recurrences remains an unresolved issue. Tumors growing in preirradiated tissues fraction hypoxic cells are more metastatic, a condition known as tumor bed effect. transcription factor hypoxia inducible (HIF)-1 promotes invasion metastasis tumors, but its role the effect has not been...
Glioblastoma are rapidly proliferating brain tumors in which hypoxia is readily recognizable, as indicated by focal or extensive necrosis and vascular proliferation, two independent diagnostic criteria for glioblastoma. Gene expression profiling of glioblastoma revealed a gene signature associated with hypoxia-regulated genes. The correlated set emerging from unsupervised analysis comprised known hypoxia-inducible genes involved angiogenesis inflammation such VEGF BIRC3, respectively....