A5026625355- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Contact Dermatitis and Allergies
- Congenital heart defects research
- Cancer Cells and Metastasis
- Cardiac Fibrosis and Remodeling
- Nitric Oxide and Endothelin Effects
- Chemical Safety and Risk Management
- Hippo pathway signaling and YAP/TAZ
- Signaling Pathways in Disease
- Pesticide Exposure and Toxicity
- Angiogenesis and VEGF in Cancer
- Phytochemistry and biological activity of medicinal plants
- Immune Cell Function and Interaction
- Cancer Risks and Factors
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- TGF-β signaling in diseases
- Cardiac Structural Anomalies and Repair
- Adipokines, Inflammation, and Metabolic Diseases
- Eicosanoids and Hypertension Pharmacology
- Mitochondrial Function and Pathology
- Occupational exposure and asthma
- Caveolin-1 and cellular processes
- Lipoproteins and Cardiovascular Health
Institut National de Recherche et de Sécurité
2023-2025
University of Fribourg
2017-2021
Laboratoire National de Santé
2012-2013
Servier (France)
2009
Colorectal cancer (CRC) is one of the most common worldwide. Chronic inflammation contributes to CRC development and progression. Emodin, a natural anthraquinone derivative with anti-oxidant, anti-inflammatory, anti-tumor activities. We used AOM/DSS model colitis-associated intestinal tumorigenesis characterize effect Emodin on at weeks 3, 5, 14 after initiation AOM. At all three time points, (50 mg/kg) reduced inflammatory cell (i.e. CD11b + F4/80 ) recruitment, cytokine TNFα, IL1α/β, IL6,...
Obesity is a strong predictor of poor prognosis in breast cancer, especially postmenopausal women. In particular, tumors obese patients tend to seed more distant metastases, although the biology behind this observation remains poorly understood. To elucidate effects microenvironment on metastatic spread, we ovariectomized C57BL/6 J female mice and fed them either regular diet (RD) or high-fat (HFD) generate diet-induced obesity model. We then studied tumor progression metastasis Py230 EO771...
Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated (AMPK), AKT Ca2+/calmodulin-dependent II (CaMKII). Membrane-associated guanylate (MAGUK) with inverted domain structure-1 (MAGI1) is an adaptor that stabilizes epithelial cell-cell contacts. The aim of this study was to assess the unknown role cell MAGI1 in response fluid stress. We show constitutive expression...
Background Administration of endothelial progenitor cells (EPC) represents a promising option to regenerate the heart after myocardial infarction, but is limited because low recruitment and engraftment in myocardium. Mobilization migration EPC are mainly controlled by stromal cell-derived factor 1α (SDF-1α) its receptor CXCR4. We hypothesized that adenosine, cardioprotective molecule, may improve heart. Methods were obtained from peripheral blood mononuclear healthy volunteers. Expression...
The kinase PI3Kγ aggravates obesity by activating macrophages and triggering inflammation in adipose tissue.
Prediction of left ventricular (LV) remodeling after acute myocardial infarction (MI) is clinically important and would benefit from the discovery new biomarkers. Blood samples were obtained upon admission in patients with ST-elevation MI who underwent primary percutaneous coronary intervention. Messenger RNA was extracted whole blood cells. LV function evaluated by echocardiography at 4-months. In a test cohort 32 patients, integrated analysis microarrays network protein-protein...
Circulating angiogenic cells (CAC) participate in cardiac repair. CAC recruitment to the ischaemic heart is mainly induced by chemokine (C–X–C motif) receptor 4 (CXCR4)/stromal-cell derived factor-1α axis. However, mobilization only partly prevented CXCR4 blockade, indicating that other mechanisms are involved. Since expression of monocyte chemotactic protein 3 (MCP3) increased hearts, we hypothesized it may mobilization. were obtained from peripheral blood mononuclear healthy volunteers. In...
Cancer stem cells (CSCs) are defined by their ability to regenerate a tumor upon transplantation. However, it is not yet clear whether tumors contain single CSC population or different subsets of with mixed capacities for initiating primary and secondary tumors. Using two identification strategies, we studied the overlap between metastatic tumor-initiating (TICs) in MMTV-PyMT model. Our results show that model, Lin−CD90−ALDHhigh retained high potential (TIP) orthotopic transplants, contrast...
The purpose of the study was to investigate renal endothelium-dependent vasodilatation in a model severe hypertension associated with kidney injury.Changes perfusion pressure were measured isolated, perfused kidneys taken from 18-week-old Wistar-Kyoto rat (WKY), spontaneously hypertensive rats (SHR) and SHR treated for 2 weeks N(ω) -nitro-L-arginine methyl ester drinking water (L-NAME-treated SHR, 6 mg·kg(-1) ·day(-1) ).Acetylcholine caused similar dose-dependent dilatation three groups. In...
Abstract Background Chemical‐induced allergies at workplace represent a significant occupational health issue. These substances must be properly identified as sensitizers. In previous studies, an original model using mouse bone marrow‐derived dendritic cells (BMDC) was developed for this purpose. Objectives The aim of study to evaluate the predictive capacity BMDC with large panel sensitizers (including pre‐ and pro‐haptens) non‐sensitizers. Methods readout from is based on expression levels...
Adenosine may have beneficial effects on left ventricular function after myocardial infarction (MI), but the magnitude of this effect remote and MI areas is controversial. We assessed long-term adenosine using electrocardiogram-triggered 18 F-fluorodeoxyglucose positron emission tomography.Wistar rats were subjected to coronary ligation randomized into three groups treated daily for 2 months by NaCl (control; n = 7), 2-chloroadenosine (CADO; 8) or CADO with 8-sulfophenyltheophilline, an...
Abstract Background Bisphenol (BP‐)A is a chemical used in Europe to produce polycarbonate plastics and epoxy resin or as colour developer thermal paper. Due its toxicity, BPA presence was restricted by European regulations. Therefore, substitute chemicals are replacing BPA. Objective To assess the allergenic sensitizing potential of 27 substitutes industry. Methods The expression two costimulatory molecules six cytokines were analysed flow cytometry mouse bone marrow‐derived dendritic cells...
Background: Increase of blood capillary density at the interface between normal and ischemic tissue after acute Myocardial Infarction (MI) reduces infarct size improves cardiac function. Cardiac injury triggers production adenosine matricellular protein Thrombospondin-1 (TSP-1). Adenosine is thought to be involved in repair known stimulate angiogenesis. However, role TSP-1 angiogenesis still debated, since both anti- pro-angiogenic activities have been reported. We hypothesized that controls...