A5018809761- Angiogenesis and VEGF in Cancer
- Hedgehog Signaling Pathway Studies
- Mesenchymal stem cell research
- Mast cells and histamine
- Fibroblast Growth Factor Research
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Cell Adhesion Molecules Research
- Natural Compound Pharmacology Studies
- Chemokine receptors and signaling
- Botanical Research and Chemistry
- Advanced Breast Cancer Therapies
- Estrogen and related hormone effects
- Protease and Inhibitor Mechanisms
- Epigenetics and DNA Methylation
University Hospital of Lausanne
2011-2025
University of Fribourg
2011-2024
University of Lausanne
2008-2024
École Polytechnique Fédérale de Lausanne
2011-2023
Centro Cardiologico Monzino
2023
Breast Center
2011
MultiMedica
2007-2009
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2009
Dartmouth College
2007
University of Insubria
2006-2007
Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular estrogen receptor negative (ER−) cancers, by reducing rates of recurrences. It is assumed that the (neo)adjuvant chemotherapy are due killing disseminated, residual cells, however, there no formal evidence for it. Here, we experimental ER− cells survived high-dose Doxorubicin Methotrexate based elicit a state immunological dormancy. Hallmark this dormant phenotype sustained activation...
Matricellular proteins play multiple roles in primary tumor growth, local invasion and angiogenesis. However, their contribution to metastasis the putative mechanisms involved are less well characterized. In ER-negative human breast cancer, elevated expression levels of matricellular protein Cysteine-rich angiogenic inducer 61 (CYR61) associated with more aggressive progression. Here, we investigated role CYR61 cancer lung using triple negative cell lines MDA-MB-231 SUM159. Silencing...
Local breast cancer relapse after breast-saving surgery and radiotherapy is associated with increased risk of distant metastasis formation. The mechanisms involved remain largely elusive. We used the well-characterized 4T1 syngeneic, orthotopic model to identify novel postradiation metastasis.4T1 cells were injected in 20 Gy preirradiated mammary tissue mimic relapses, or nonirradiated tissue, as control, immunocompetent BALB/c mice. Molecular, biochemical, cellular, histologic analyses,...
Brain metastasis is a complication of increasing incidence in patients with breast cancer at advanced disease stage. It severe condition characterized by rapid decline quality life and poor prognosis. There critical clinical need to develop effective therapies prevent treat brain metastases. Here, we describe unique robust spontaneous preclinical model the (4T1-BM 2 ) mice that has been instrumental uncovering molecular mechanisms guiding metastatic dissemination colonization brain. Key...
Cancer cell plasticity contributes to therapy resistance and metastasis, which represent the main causes of cancer-related death, including in breast cancer. The tumor microenvironment drives cancer unravelling underlying cues may provide novel strategies manage metastatic disease. Using experimental models transcriptomic analyses, we showed that stem antigen-1 positive (SCA1+) murine cells enriched during progression metastasis had higher vitro cell-like properties, enhanced vivo ability,...
Abstract We show that the synthetic oleanane triterpenoid, CDDO-methyl ester (CDDO-Me; methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate) is an effective agent for suppressing angiogenesis, both in cell culture and vivo. The potency of CDDO-Me particularly striking when dosed vivo to inhibit angiogenic effects vascular endothelial growth factor tumor necrosis factor-α Matrigel sponge assays; activity seen at i.p. doses as low 0.003 mg/kg body weight. If sponges are impregnated with just before...
Angiostatin, an endogenous angiogenesis inhibitor, is a fragment of plasminogen. Its anti-angiogenic activity was discovered with functional assays in vivo, however, its direct action on endothelial cells moderate and identification definitive mechanisms has been elusive to date. We had previously demonstrated that innate immune are key targets angiostatin, however the pathway involved this immune-related inhibition not known. Here we present evidence IL-12, principal TH1 cytokine potent...
Neurocognitive disorders are a major public health challenge, affecting 55 million people, and projected to triple by 2050. This year's research highlights pathological mechanisms such as mitochondrial dysfunction brain inflammation. Modifiable risk factors, vision loss, underscore the importance of early prevention. A Swiss study reveals high prevalence inappropriate drug prescriptions in elderly. Anti-amyloid treatments, lecanemab donanemab, show promising results. Lastly, anticoagulation...
Hyperforin (Hyp), a polyphenol-derivative of St. John9s wort (<i>Hypericum perforatum</i>), has emerged as key player not only in the antidepressant activity plant but also an inhibitor bacteria lymphocyte and tumor cell proliferation, matrix proteinases. We tested whether well inhibiting leukocyte elastase (LE) activity, Hyp might be effective containing both polymorphonuclear neutrophil (PMN) recruitment unfavorable eventual tissue responses. The results show that, without affecting vitro...
Abstract Tumor-mobilized bone marrow–derived CD11b+ myeloid cells promote tumor angiogenesis, but how and when these acquire proangiogenic properties is not fully elucidated. Here, we show that myelomonocytic develop during their differentiation from CD34+ hematopoietic progenitors placenta growth factor (PlGF) critical in promoting this education. Cultures of human supplemented with conditioned medium breast cancer cell lines or PlGF, nontumorigenic epithelial lines, generate capable...
The p120 RasGAP protein negatively regulates Ras via its GAP domain. carries several other domains that modulate signaling molecules such as Rho. is also a caspase‐3 substrate. One of the caspase‐3‐generated fragments, corresponding to amino acids 158–455 and called fragment N2, was previously reported specifically sensitize cancer cells death induced by various anticancer agents. Here, we show N2 inhibits migration in vitro it impairs metastatic progression breast lung. Hence,...
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis treatment, including the occurrence, development, progression, metastasis, treatment oncologic disease. It covers basic, translational clinical research related to cell biology, genomics, precision medicine, oncology internal radiotherapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neurooncology, etc.