A5088604141- Angiogenesis and VEGF in Cancer
- Melanoma and MAPK Pathways
- Mesenchymal stem cell research
- Wnt/β-catenin signaling in development and cancer
- 14-3-3 protein interactions
- Cancer Treatment and Pharmacology
- Fibroblast Growth Factor Research
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- Lipid metabolism and disorders
- Neuroendocrine Tumor Research Advances
- Animal Genetics and Reproduction
- Nutrition, Genetics, and Disease
- Lymphatic System and Diseases
- Cellular Mechanics and Interactions
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Pancreatic function and diabetes
- Medicinal Plants and Bioactive Compounds
- Pharmacogenetics and Drug Metabolism
- Glutathione Transferases and Polymorphisms
- Biological Research and Disease Studies
- Cancer, Lipids, and Metabolism
- Cell death mechanisms and regulation
European Institute of Oncology
2007-2023
University of Basel
2011-2020
Inserm
2015
École Polytechnique Fédérale de Lausanne
2011
Breast Center
2011
University of Fribourg
2011
University of Lausanne
2011
University Hospital of Lausanne
2011
San Raffaele University of Rome
2004
Despite the approval of several anti-angiogenic therapies, clinical results remain unsatisfactory, and transient benefits are followed by rapid tumor recurrence. Here, we demonstrate potent efficacy multi-kinase inhibitors nintedanib sunitinib in a mouse model breast cancer. However, after an initial regression, tumors resume growth absence active angiogenesis. Gene expression profiling cells reveals metabolic reprogramming toward anaerobic glycolysis. Indeed, combinatorial treatment with...
Members of the Angiopoietin family regulate various aspects physiologic and pathologic angiogenesis. Although Angiopoietin-1 (Ang-1) decreases endothelial cell permeability increases vascular stabilization via recruitment pericytes smooth muscle cells to growing blood vessels, Angiopoietin-2 (Ang-2) mediates angiogenic sprouting regression. In this study, we used Rip1Tag2 transgenic mouse model pancreatic β-cell carcinogenesis investigate roles Ang-1 Ang-2 in tumor angiogenesis progression....
Abstract Focal adhesion kinase (FAK) is a cytoplasmic tyrosine that regulates plethora of downstream signaling pathways essential for cell migration, proliferation and death, processes are exploited by cancer cells during malignant progression. These well-established tumorigenic activities, together with its high expression activity in different types, highlight FAK as an attractive target therapy. We have assessed characterized the therapeutic potential biological effects BI 853520, novel...
Abstract The Src homology and collagen (Src) family of adaptor proteins comprises six Shc-like encoded by three loci in mammals (Shc, Rai, Sli). are tyrosine kinase substrates, which regulate diverse signaling pathways cellular functions, including Ras proliferation (p52/p46Shc), phosphatidylinositol 3-kinase survival (p54Rai), mitochondrial permeability transition apoptosis (p66Shc). Here, we report the identification, cloning, sequence characterization a new member Shc that termed RaLP....
Pancreatic neuroendocrine tumors (PNET) represent a rare but challenging heterogeneous group of cancers with an increasing incidence over the last number decades. Herein, we report in-depth evaluation new antiangiogenic small-molecule tyrosine kinase inhibitor (TKI) nintedanib in preclinical Rip1Tag2 transgenic mouse model carcinoma pancreas (insulinoma).We have assessed and antitumor activity nintedanib, comparison other TKI, by treating mice different treatment schedules complemented...
Abstract Tumor-mobilized bone marrow–derived CD11b+ myeloid cells promote tumor angiogenesis, but how and when these acquire proangiogenic properties is not fully elucidated. Here, we show that myelomonocytic develop during their differentiation from CD34+ hematopoietic progenitors placenta growth factor (PlGF) critical in promoting this education. Cultures of human supplemented with conditioned medium breast cancer cell lines or PlGF, nontumorigenic epithelial lines, generate capable...
Abstract Pygopus 2 (Pygo2) is a coactivator of Wnt/β-catenin signaling that can bind bi- or trimethylated lysine 4 histone-3 (H3K4me2/3) and participate in chromatin reading writing. It remains unknown whether the Pygo2–H3K4me2/3 association has functional relevance breast cancer progression vivo. To investigate histone-binding activity Pygo2 malignant cancer, we generated knock-in mouse model where binding to H3K4me2/3 was rendered ineffective. Loss Pygo2–histone interaction resulted...
De novo formation of blood vessels is a pivotal mechanism during cancer development. During the past few years, antiangiogenic drugs have been developed to target tumor vasculature. However, because limitations and adverse effects observed with current therapies, there strong need for alternative strategies. Using specific anti-junctional adhesion molecule (JAM)-B antibodies Jam-b-deficient mice, we studied role in antiangiogenesis JAM-B. We found that against murine JAM-B, an...
Abstract Oligodendrocytes and Schwann cells use diverse regulatory elements to transcribe myelin basic protein ( Mbp ). For example, an enhancer 9.0 kb upstream of SCE1) activated either the proximal or hsp68 promoters only in transgenic mice. Here, we analyze SCE1 vitro vivo show that also activates another gene, Mpz , specifically Surprisingly, although behaves as cells, here for first time it transcription robustly cultured oligodendrocytes, but from its original genomic position. Diverse...
Background: Metastatic melanoma remains one of the most aggressive forms cancer, with a survival expectation above six months only in rare cases. Despite advances characterization underlying molecular pathways and development specific targeted treatments, available chemo- immuno-therapy are unable to prolong significantly advanced-stage melanoma. Rai like protein (RaLP) is newly identified Src homology 2 domain containing (Shc) family member selectively expressed during transition metastatic...
Supplementary Figure 3 from RaLP, a New Member of the Src Homology and Collagen Family, Regulates Cell Migration Tumor Growth Metastatic Melanomas
Supplementary Figure 2 from RaLP, a New Member of the Src Homology and Collagen Family, Regulates Cell Migration Tumor Growth Metastatic Melanomas
Supplementary Figure 4 from RaLP, a New Member of the Src Homology and Collagen Family, Regulates Cell Migration Tumor Growth Metastatic Melanomas
Supplementary Figure 1 from RaLP, a New Member of the Src Homology and Collagen Family, Regulates Cell Migration Tumor Growth Metastatic Melanomas
<div>Abstract<p>The Src homology and collagen (Src) family of adaptor proteins comprises six Shc-like encoded by three loci in mammals (Shc, Rai, Sli). are tyrosine kinase substrates, which regulate diverse signaling pathways cellular functions, including Ras proliferation (p52/p46Shc), phosphatidylinositol 3-kinase survival (p54Rai), mitochondrial permeability transition apoptosis (p66Shc). Here, we report the identification, cloning, sequence characterization a new member Shc...
Supplementary Figure 1 from RaLP, a New Member of the Src Homology and Collagen Family, Regulates Cell Migration Tumor Growth Metastatic Melanomas
Supplementary Figure 4 from RaLP, a New Member of the Src Homology and Collagen Family, Regulates Cell Migration Tumor Growth Metastatic Melanomas
Supplementary Figure 3 from RaLP, a New Member of the Src Homology and Collagen Family, Regulates Cell Migration Tumor Growth Metastatic Melanomas
Supplementary Figure 2 from RaLP, a New Member of the Src Homology and Collagen Family, Regulates Cell Migration Tumor Growth Metastatic Melanomas
<div>Abstract<p>The Src homology and collagen (Src) family of adaptor proteins comprises six Shc-like encoded by three loci in mammals (Shc, Rai, Sli). are tyrosine kinase substrates, which regulate diverse signaling pathways cellular functions, including Ras proliferation (p52/p46Shc), phosphatidylinositol 3-kinase survival (p54Rai), mitochondrial permeability transition apoptosis (p66Shc). Here, we report the identification, cloning, sequence characterization a new member Shc...
<div>Abstract<p>Members of the Angiopoietin family regulate various aspects physiologic and pathologic angiogenesis. Although Angiopoietin-1 (Ang-1) decreases endothelial cell permeability increases vascular stabilization via recruitment pericytes smooth muscle cells to growing blood vessels, Angiopoietin-2 (Ang-2) mediates angiogenic sprouting regression. In this study, we used Rip1Tag2 transgenic mouse model pancreatic β-cell carcinogenesis investigate roles Ang-1 Ang-2 in...
<p>Suppl. Video 1: Confocal analysis of a Pygo2+/+ tumor spheroid stained for b-catenin. (Related to Figure S2C).</p>