Abstract It is quite generally assumed that the overdamped Langevin equation provides a quantitative description of dynamics classical Brownian particle in long time limit. We establish and investigate paradigm anomalous diffusion process governed by an underdamped with explicit dependence system temperature thus damping coefficients. show for this scaled motion (UDSBM) limit fails to describe behaviour may practically even not exist at all certain range parameter values. Thus persistent...

The emerging diffusive dynamics in many complex systems show a characteristic crossover behaviour from anomalous to normal diffusion which is otherwise fitted by two independent power-laws. A prominent example for subdiffusive–diffusive are viscoelastic such as lipid bilayer membranes, while superdiffusive–diffusive crossovers occur of actively moving biological cells. We here consider the general stochastic particle driven so-called tempered fractional Gaussian noise, that noise with...

Abstract We investigate a diffusion process with time-dependent coefficient, both exponentially increasing and decreasing in time, <?CDATA $D(t) = D_0 e^{\pm 2 \alpha t} $?> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mi>D</mml:mi> <mml:mo stretchy="false">(</mml:mo> <mml:mi>t</mml:mi> stretchy="false">)</mml:mo> <mml:mo>=</mml:mo> <mml:msub> <mml:mn>0</mml:mn> </mml:msub> <mml:msup> <mml:mi>e</mml:mi> <mml:mrow> <mml:mo>±</mml:mo> <mml:mn>2</mml:mn>...

Scaled Brownian motion (SBM) is widely used to model anomalous diffusion of passive tracers in complex and biological systems. It a highly nonstationary process governed by the Langevin equation for motion, however, with power-law time dependence noise strength. Here we study aging properties SBM both unconfined confined motion. Specifically, derive ensemble averaged mean squared displacements analyze their behavior regimes weak, intermediate, strong aging. A very rich revealed depending on...

We investigate both analytically and by computer simulations the ensemble- time-averaged, nonergodic, aging properties of massive particles diffusing in a medium with time dependent diffusivity. call this stochastic diffusion process (aging) underdamped scaled Brownian motion (UDSBM). demonstrate how mean squared displacement (MSD) time-averaged MSD UDSBM are affected inertial term Langevin equation, at short, intermediate, even long times. In particular, we quantify ballistic regime for as...

In many social complex systems, in which agents are linked by non-linear interactions, the history of events strongly influences whole network dynamics. However, a class "commonly accepted beliefs" seems rarely studied. this paper, we examine how growth process (social) is influenced past circumstances. order to tackle cause, simply modify well known preferential attachment mechanism imposing time dependent kernel function evolution equation. This approach leads fractional Barabási-Albert...

Loop-mediated isothermal amplification is a promising candidate for the rapid detection of Mycobacterium tuberculosis. However, high potential carry-over contamination main obstacle to its routine use. Here, closed tube LAMP was intended visual Mtb compare turbidimetric and two more favorable colorimetric methods using calcein hydroxy naphthol blue (HNB). Additionally, less studied dye (i.e., eriochrome black T (EBT)) optimized in detail reaction first time. purified DNA 30 clinical...

The production of β-lactamase enzymes such as AmpC β-lactamases and extended-spectrum (ESBLs) is among the main mechanisms for resistance to expanded-spectrum cephalosporins. present study was conducted investigate prevalence molecular epidemiology plasmid-mediated beta (β)-lactamase in ESBL co-producing Escherichia coli (E. coli) Klebsiella spp. (Klebsiella pneumoniae oxytoca) clinical isolates northeast Iran. A total 602 E. were collected from three hospitals Mashhad (northeast Iran)....

We examine the non-ergodic properties of scaled Brownian motion (SBM), a non-stationary stochastic process with time dependent diffusivity form . compute ergodicity breaking parameter EB in entire range scaling exponents α, both analytically and via extensive computer simulations Langevin equation. demonstrate that limit long trajectory lengths T short lag times Δ as function exponent α has no divergence at = 1/2 present asymptotes for different limits. generalize analytical results averaged...

The emergence of phenotypic diversity in a population cells and their arrangement space time is one the most fascinating features living systems. In fact, understanding multicellularity unthinkable without explaining proximate ultimate causes cell differentiation space. Simpler forms can be found unicellular organisms, such as bacterial biofilm, where reversible results phenotypically diverse populations. this manuscript, we attempt to start with simple case nongenetic construct model...

Pathogenic mycobacteria are a major cause of human morbidity and mortality. Mycobacterium tuberculosis is an etiological agent (TB). Designing new vaccines, including DNA may be useful strategy for preventing TB.The purpose this study was to design construct eukaryotic expression vector containing M. tuberculosis.Genomic H37Rv cultured on Lowenstein Jensen medium extracted, cfp10 amplified by PCR. After digesting the PCR product plasmid, fragment ligated into pcDNA3.1 (+). Correct insertion...

In this project, we employed ethanolic (EMI) and aqueous (AMI) extracts of mango (Mangifera indica L., Anacardiaceae) fruit seeds as a modulator antibiotic resistance against multidrug-resistant (MDR) Pseudomonas aeruginosa Acinetobacter baumannii to evaluate natural compounds isolated from by-products or waste edible plants. We also investigated the effect these alone in combination with standard classes antibiotics desired strains. M. were processed exploited using ethanol water. The...

Background: Pathogenic mycobacteria are one of major causes human morbidity and mortality. Mycobacterium tuberculosis (M. tuberculosis) is an etiological agent tuberculosis. Designing new vaccines including DNA may be considered as approaches for preventing TB. Materials Methods: M. H37Rv was grown on Lowenstein Jensen medium 4 weeks at 37oC then extracted. The cfp10 gene amplified by PCR. After digesting the PCR product plasmid, fragment ligated into vector using T4 ligase. Then, Ag85A...

• A previously healthy 20-year-old woman died of a progressive cerebral disease that involved the brain stem and hemispheres successively. The illness ran its course in 80 days. Postmortem examination showed multifocal necrotizing encephalopathy chiefly affected gray matter structures was mainly located cortex. cause pathogenesis remain unknown.

Remaining unidentified, nontuberculous mycobacteria (NTM) infections would possibly be treated improperly causing serious complications and burden patients with high costs. The current study aimed to identify differentiate NTM from each other by molecular methods rationalize therapy. In a cross-sectional study, specimens were collected 843 referred Regional Tuberculosis Reference Laboratory of Northeast Iran. Mycobacterial culture was performed for 498 according physicians9 request. DNA...

Abstract One of the major transitions in evolution is step from unicellularity into brave new world multicellularity. To understand this feat, one has to fathom two main characteristics multicellular organisms: differentiation and self-organization. Any explanation concerning transition should involve mechanisms that can simultaneously explain marvellous intricacies manifest aforementioned characteristics, an account such traits. Here we propose a noise-driven (NDD) model. The reliance on...