A5008768924- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Tuberculosis Research and Epidemiology
- Vector-Borne Animal Diseases
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Antibiotic Resistance in Bacteria
- Liver Disease Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Mycobacterium research and diagnosis
- Pharmaceutical and Antibiotic Environmental Impacts
- Immunodeficiency and Autoimmune Disorders
- Hepatitis Viruses Studies and Epidemiology
- Diagnosis and treatment of tuberculosis
- Retinoids in leukemia and cellular processes
- Immunotherapy and Immune Responses
- Antibiotic Use and Resistance
- vaccines and immunoinformatics approaches
- Galectins and Cancer Biology
- Infectious Encephalopathies and Encephalitis
- Bacteriophages and microbial interactions
- Nosocomial Infections in ICU
- Immunotoxicology and immune responses
- Peptidase Inhibition and Analysis
- Transgenic Plants and Applications
Academic Center for Education, Culture and Research
2016-2024
High Institute for Education and Research in Transfusion Medicine
2024
Mashhad University of Medical Sciences
2014-2020
Islamic Azad University, Mashhad
2016
The production of β-lactamase enzymes such as AmpC β-lactamases and extended-spectrum (ESBLs) is among the main mechanisms for resistance to expanded-spectrum cephalosporins. present study was conducted investigate prevalence molecular epidemiology plasmid-mediated beta (β)-lactamase in ESBL co-producing Escherichia coli (E. coli) Klebsiella spp. (Klebsiella pneumoniae oxytoca) clinical isolates northeast Iran. A total 602 E. were collected from three hospitals Mashhad (northeast Iran)....
ObjectivesHuman papillomaviruses (HPV) are the main etiology of invasive cervical cancer. Together HPV and viral hepatitis account for cause 25% cancers in developing countries. To evaluate association between population movements spread HPV, this study looked at prevalence, genotypes, phylogenetic assessment Great Khorasan, a pilgrimage-tourism province northeast Iran.MethodsFrom March 2013 to July 2018, 567 samples were collected from three groups Khorasan: Razavi North Khorasan provinces...
In acute conditions, severe respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage due to the induction of inappropriate immune responses, particularly lung tissue fibrosis. To evaluate consequence deterioration system, autoimmune markers were assessed.In a case-control study, 108 patients with disease 2019 (COVID-19) admitted intensive care unit (ICU), and 158 outpatients mild clinical symptoms, SARS-CoV-2 reverse transcription quantitative polymerase chain reaction...
This study determined the mechanisms and patterns of antimicrobial resistance among isolates obtained from different wards a teaching hospital in city Mashhad north-east Iran. Between January 2012 end June 2012, 36 Acinetobacter baumannii were collected Ghaem Hospital. Antimicrobial susceptibility testing epsilometer (E-test) performed. The genetic determinants A, B D classes β-lactamases, aminoglycoside modifying enzymes (AMEs), efflux pumps ISAba1 elements assessed by PCR. Repetitive...
Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of HTLV-1-host interactions in infected TCD4+ cells. In this study, the HTLV-1 proviral load (PVL) and HBZ as viral elements AKT1, BAD, FOXP3, RORγt IFNλ3 host factors were investigated.The study was conducted ATLLs, HTLV-1-associated myelopathy/tropical spastic paraparesis patients (HAM/TSPs) HTLV-1-asympthomatic carriers (ACs). The DNA mRNA from peripheral blood mononuclear cells extracted for gene expression...
Tuberculosis (TB) remains a major global health threat despite chemotherapy and Bacilli Calmette–Guérin (BCG) vaccination.
Abstract Acute intoxication with diazinon (DZN) as a pesticide causes mortality and morbidity annually. This study shows the impact of sub-acute toxicity DZN 20 mg/kg protective activities chrysin (CH) flavone under flavonoids family (12.5, 25 50 mg/kg) were assessed on BALB/c mouse immune system. The changes in morphological functional properties system thymus, spleen liver histopathology, sub-populations T lymphocytes, cytokines levels, transcription factors, complement function,...
Abstract One of the most critical challenges genetic engineering is expression recombinant proteins using biological systems. Nowadays, different systems from bacteria to mammalian tissue culture cells are available for production medical and industrial purposes. Among various choices, yeast such as Pichia pastoris promising candidates. The P. system a standard tool biopharmaceuticals enzymes. It also considered unique host subunit vaccines which could significantly affect growing market...
The final step of epigenetic processes is changing the gene expression in a new microenvironment body, such as neuroendocrine changes, active infections, oncogenes, or chemical agents. case tuberculosis (TB) an outcome Mycobacterium (M.tb) and host interaction manifestation latent TB clearance. This comprehensive review explains interprets epigenetics findings regarding expressions on host-pathogen interactions development progression tuberculosis. introduces novel insights into complicated...
Despite treatment with antibiotics and vaccination BCG, tuberculosis (TB) is still considered as one of the most important public health problems in world. Therefore, designing producing a more effective vaccine against TB seems urgently. In this study, immunogenicity fusion protein which consisting or comprising CFP-10 from Mycobacterium Fc-domain mouse IgG2a was evaluated novel subunit candidate TB.The genetic constructs were cloned pPICZαA expression vector recombinant vectors...
One third of the world population has a history exposure to hepatitis B virus (HBV), and two billion people are infected with latent tuberculosis (TB). Occult infection (OBI) is defined as presence replicative-competent HBV DNA in liver detectable or undetectable serum individuals testing negative for surface antigen (HBsAg). Screening could identify OBI significantly reduce carriers complications chronic (CHB). This study aims assess serological markers molecular diagnosis among TB Mashhad,...
Despite advances in the treatment of adult T-cell leukemia/lymphoma (ATLL), survival rate this malignancy remains significantly low. Auraptene (AUR) is a natural coumarin with broad-spectrum anticancer activities. To introduce more effective therapeutic strategy for ATLL, we investigated combinatorial effects AUR and arsenic trioxide (ATO) on MT-2 cells.The cells were treated different concentrations 24, 48, 72 hr, viability was measured by alamarBlue assay. Then, combination (20 μg/ml) ATO...