A5077484791- Alzheimer's disease research and treatments
- Enzyme Production and Characterization
- Protein Structure and Dynamics
- Natural Antidiabetic Agents Studies
- Enzyme Structure and Function
- Computational Drug Discovery Methods
- Biochemical effects in animals
- Protein Interaction Studies and Fluorescence Analysis
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Protein purification and stability
- Cholinesterase and Neurodegenerative Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Enzyme Catalysis and Immobilization
- Dendrimers and Hyperbranched Polymers
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Analysis and Sensing Techniques
- Phytochemicals and Antioxidant Activities
- Curcumin's Biomedical Applications
- RNA Interference and Gene Delivery
- Prion Diseases and Protein Misfolding
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
Tehran University of Medical Sciences
2016-2025
NorthShore University HealthSystem
2023
Yale University
2023
Pontificia Universidad Católica Argentina
2023
University of Illinois Chicago
2023
Northwestern University
2023
Family Medicine Residency of Idaho
2023
Islamic Azad University, Science and Research Branch
2008-2023
Hamedan University of Medical Sciences
2023
Shariati Hospital
2008-2017
Recently, the world has been dealing with a new type of coronavirus called COVID-19 that in terms symptoms is similar to SARS coronavirus. Unfortunately, researchers could not find registered therapy treat infection related virus yet. Regarding fact drug repurposing good strategy for epidemic viral infection, we applied using virtual screening identify therapeutic options COVID-19. For this purpose, five proteins (3-chymotrypsin-like protease (3CLpro), Papain-Like (PLpro), cleavage site, HR1...
Amyloid aggregation of polypeptides is related to a growing number pathologic states known as amyloid disorders. There great deal interest in developing small molecule inhibitors the amyloidogenic processes. In present article, inhibitory effects some indole derivatives on fibrillation hen egg white lysozyme (HEWL) are reported. Acidic pH and high temperatures were used drive HEWL towards formation. A variety techniques, ranging from thioflavin T fluorescence Congo red absorbance assays...
Background: Caffeine is a widely consumed psychostimulant with various effects, including on weight metabolic parameters. Blood glucose levels increase and reduced insulin sensitivity have been reported over caffeine consumption. Since xanthine derivatives like can activate alpha-amylase, an enzyme essential for carbohydrate-to-glucose conversion, this study investigates whether translates to increased amylase activity in living organisms explores potential gene expression changes. Methods:...
trans-Chalcone is the core structure of naringenin chalcone, located halfway in biosynthesis pathway flavonoids. Flavonoids have been reported as mammalian alpha-amylase inhibitors, a property which could be useful management postprandial hyperglycemia diabetes and related disorders. As inhibitor vitro, putative beneficial effect trans-chalcone on was tested streptozotocin-induced rat model type 1, results analyzed with commonly used statistical methods. Significant reduction blood glucose...
Abstract Electrospinning, a simple and versatile method to fabricate nanofibrous supports, has attracted continuous attention in the field of enzyme immobilization. In this study, acetylcholinesterase (AChE) been successfully immobilized PVA nanofibers via electrospinning mixture AChE, BSA as an stabilizing additive PVA. The maximum activity recovery AChE was about 40%. comparison with free enzyme, showed improved stability while retaining considerable amount at lower pH values. Moreover,...
Abstract Formation of toxic amyloid structures is believed to be associated with various late‐onset neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. The fact that many proteins in addition those are clinical conditions have the potential form fibrils vitro provides opportunities for studying fundamentals protein aggregation formation model systems. Accordingly, considerable interest effort has been directed toward developing small molecules inhibit fibrillar...
The 25-35 fragment of the amyloid β (Aβ) peptide is a naturally occurring proteolytic by-product that retains pathophysiology its larger parent molecule, whose deposition has been shown to involve mitochondrial dysfunction. Hence, disruption Aβ(25-35) aggregates could afford an effective remedial strategy for Alzheimer's disease (AD). In present study, effect number selected small-molecule natural products (polyphenols: resveratrol, quercetin, biochanin A, and indoles: indole-3-acetic acid,...
Since the formation of amyloid structures from proteins was recognized in numerous diseases, many efforts have been devoted to task finding effective anti-amyloidogenic compounds. In a number these investigations, existence "generic" compounds is implicitly acknowledged. Curcumin seems be one compounds, possessing key structural components toward fibrillation prevention, and its property has reported for model disease-related such as lysozyme alpha-synuclein. this study, insulin shown...
Poly(amidoamine) (PAMAM) dendrimers are promising nanocarriers that can enhance the solubility of hydrophobic drugs. The surface chemistry is great relevance as end groups these be easily modified to improve bioavailability and sustained release cargo. Therefore, a molecular-level understanding host-guest interactions give both qualitative quantitative information particularly desirable. In this work, fully atomistic molecular dynamics simulations were used study association bioactive...